Category: 42872-30-0

Skwierawska, Anna published the artcileRemoval of nonsteroidal anti-inflammatory drugs and analgesics from wastewater by adsorption on crosslinked β-cyclodextrin, Computed Properties of 42872-30-0, the main research area is nonsteroidal antiinflammatory drug analgesics removal adsorption wastewater crosslinked cyclodextrin.

We present a method using the material in the form of crosslinked β-cyclodextrin (CD) showing high efficiency in the simultaneous removal of hazardous pollutants from sewage, such as diclofenac (DIC), ibuprofen (IBU), ketoprofen (KETO), naproxen (NAPR), salicylic acid (SALI) and tramadol (TRAM). The material is stable and particularly easy to regenerate. The sorbent probably remembers the shape of the contaminants, which increases its sorption capacity after the second use. The kinetics of the KETO adsorption process from one-, two- and three-component solutions are well described by the pseudo-second-order model. The maximum polymer capacity was 162.60 mg g-1. The interactions of KETO with CD were investigated, indicating that the main sorption mechanism is based on supramol. interaction and uptake by a polymer network. The material is not sensitive to low pH and high salinity, so it can be used for the treatment of DIC, IBU, and KETO post-production wastewaters.

Water Resources and Industry published new progress about Adsorption. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Computed Properties of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Skwierawska, Anna published the artcileRemoval of nonsteroidal anti-inflammatory drugs and analgesics from wastewater by adsorption on crosslinked β-cyclodextrin, Computed Properties of 42872-30-0, the main research area is nonsteroidal antiinflammatory drug analgesics removal adsorption wastewater crosslinked cyclodextrin.

We present a method using the material in the form of crosslinked β-cyclodextrin (CD) showing high efficiency in the simultaneous removal of hazardous pollutants from sewage, such as diclofenac (DIC), ibuprofen (IBU), ketoprofen (KETO), naproxen (NAPR), salicylic acid (SALI) and tramadol (TRAM). The material is stable and particularly easy to regenerate. The sorbent probably remembers the shape of the contaminants, which increases its sorption capacity after the second use. The kinetics of the KETO adsorption process from one-, two- and three-component solutions are well described by the pseudo-second-order model. The maximum polymer capacity was 162.60 mg g-1. The interactions of KETO with CD were investigated, indicating that the main sorption mechanism is based on supramol. interaction and uptake by a polymer network. The material is not sensitive to low pH and high salinity, so it can be used for the treatment of DIC, IBU, and KETO post-production wastewaters.

Water Resources and Industry published new progress about Adsorption. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Computed Properties of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Layh, Norman published the artcileEnantioselective hydrolysis of ketoprofen amide by Rhodococcus sp. C3II and Rhodococcus erythropolis MP 50, Application of 2-(3-Benzoylphenyl)propanenitrile, the main research area is enantioselective hydrolysis ketoprofen amide Rhodococcus.

The resolution of racemic ketoprofen amide by whole cells of Rhodococcus erythropolis MP 50 and Rhodococcus sp. C3II was studied. With both strains, racemic ketoprofen amide was converted to S-ketoprofen with an enantiomeric excess >97% at a conversion rate up to 40% of the theor. value. The sp. activity of strain MP 50 for ketoprofen amide was ∼0.12 μmol/min-mg dry weight and the substrate was converted for several hours at a constant rate.

Biotechnology Letters published new progress about Fermentation. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Application of 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bauer, R. published the artcileEnantioselective hydration of 2-arylpropionitriles by a nitrile hydratase from Agrobacterium tumefaciens strain d3, Computed Properties of 42872-30-0, the main research area is enantioselective hydration arylpropionitrile nitrile hydratase Agrobacterium.

The enantioselective nitrile hydratase from the bacterium Agrobacterium tumefaciens d3 was purified and completely separated from the amidase activity that is also present in cell extracts prepared from this strain. The nitrile hydratase had an activity optimum at pH 7.0 and a temperature optimum of 40 °C. The holoenzyme had a mol. mass of 69 kDa, the subunits a mol. mass of 27 kDa. The enzyme hydrated various 2-arylpropionitriles and other aromatic and heterocyclic nitriles. With racemic 2-phenylpropionitrile, 2-phenylbutyronitrile, 2-(4-chlorophenyl)propionitrile, 2-(4-methoxy)propionitrile or ketoprofen nitrile the corresponding (S)-amides were formed enantioselectively. The highest enantiomeric excesses (ee > 90% until about 30% of the resp. substrates were converted) were found for the amides formed from 2-phenylpropionitrile, 2-phenylbutyronitrile and ketoprofen nitrile. For the reaction of the purified nitrile hydratase, higher ee values were found than when whole cells were used in the presence of an inhibitor of the amidase activity. The enantioselectivity of the whole-cell reaction was enhanced by increasing the reaction temperature

Applied Microbiology and Biotechnology published new progress about Enzyme kinetics. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Computed Properties of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pietta, Piergiorgio published the artcilePurity assay of ketoprofen by high-performance liquid chromatography, Synthetic Route of 42872-30-0, the main research area is ketoprofen purity HPLC; liquid chromatog ketoprofen.

A HPLC method is suitable for purity assay of ketoprofen (I) [22071-15-4]. A Hibar LiChrocart RP C18 column with pH 2.7 MeCO-H2O (37:63) with 50% H3PO4 as eluent and detection at 254 nm are used. Et 4-hydroxybenzoate was chosen as internal standard Linearity was established by chromatographing standard solutions over the range 10-200 ng. The main impurity was 2-[3-(4-methylbenzoyl)phenyl]propionic acid (II) [107257-20-5] (�.4%), while the content of 3-benzoylphenylacetic acid (III) [22071-22-3] was about 0.05%. 2-(3-Benzoylphenyl)propionitrile  [42872-30-0] was almost absent. The method is specific and reproducible.

Journal of Chromatography published new progress about ketoprofen purity HPLC; liquid chromatog ketoprofen. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Synthetic Route of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mannucci, C. published the artcileHigh-performance liquid chromatography simultaneous quantitation of ketoprofen and parabens in a commercial gel formulation, Application of 2-(3-Benzoylphenyl)propanenitrile, the main research area is ketoprofen paraben determination gel HPLC; chromatog liquid ketoprofen paraben gel.

A simple and rapid procedure for quantitation of ketoprofen and parabens simultaneously in a com. gel formulation by reversed-phase HPLC was developed. The chromatog. anal. was undertaken on a Hypersil ODS column by using a solvent mixture composed of MeCN-KH2PO4 isocratically with a UV detection at 254 nm. Ketoprofen related impurities and hydrolysis product of parabens are well resolved in these conditions and the method can be applied to quality control anal. of ketoprofen and parabens in gel formulation.

Journal of Liquid Chromatography published new progress about ketoprofen paraben determination gel HPLC; chromatog liquid ketoprofen paraben gel. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Application of 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Beaulieu, Normand published the artcileLiquid chromatographic determination of ketoprofen and its related compounds in raw materials, capsules, and enteric coated tablets, Formula: C16H13NO, the main research area is ketoprofen impurity determination liquid chromatog.

A liquid chromatog. method for the determination of ketoprofen and 6 known related compounds was developed. The lower limit of quantitation of the related compounds in the drug is 0.05% or less for all compounds, and the precision of the drug assay method is �.5%. The highest levels of impurities found in 3 drug raw material samples and 4 solid oral dosage formulations were 1.37 and 0.43%, resp.

Journal – Association of Official Analytical Chemists published new progress about ketoprofen impurity determination liquid chromatog. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koppala, Srinivasarao published the artcileDevelopment and validation of a novel stability-indicating RP-HPLC method for the simultaneous determination of related substances of ketoprofen and omeprazole in combined capsule dosage form, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is ketoprofen omeprazole capsule RP HPLC.

A novel, simple, sensitive, selective and reproducible stability-indicating high performance liquid chromatog. method was developed for the quant. determination of degradation products and process-related impurities of ketoprofen (KET) and omeprazole (OMZ) in combined oral solid dosage form. Chromatog. separation was achieved on a Phenomenex Luna C18 (2) column (150 × 4.6 mm, 5 μm) under gradient elution by using a binary mixture of potassium dihydrogen phosphate buffer and acetonitrile at a flow rate of 0.8 mL/min. Chromatogram was monitored at 233 nm for KET impurities and at 305 nm for OMZ impurities using a dual wavelength UV detector. Resolution for KET and OMZ and 14 impurities was found to be >1.5 for any pair of components. Typical retention behaviors of impurities at various pH values were depicted graphically. To prove the stability-indicating power of the method, the drug product was subjected to hydrolytic, oxidative, photolytic, humidity and thermal stress conditions as per ICH. The developed method was validated according to the current ICH guidelines for specificity, limit of detection, limit of quantification, linearity, accuracy, precision, ruggedness and robustness.

Journal of Chromatographic Science published new progress about Acid hydrolysis. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Babon, Juan C. published the artcileDihydroboration of Alkyl Nitriles Catalyzed by an Osmium-Polyhydride: Scope, Kinetics, and Mechanism, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is dihydroboration alkyl nitrile catalyst osmium polyhydride kinetics mechanism; diboryl amine preparation.

Complex OsH6(PiPr3)2 is an efficient catalyst precursor for the addition of pinacolborane and catecholborane to the C-N triple bond of alkyl nitriles. In this way, a variety of N,N-diborylamines have been isolated and fully characterized, including 13 derivatives not described so far. The range of nitriles used is wide and comprises substrates having unfunctionalized linear and branched chains, and functionalized chains with methoxide, trifluoromethyl, aryl, pyridyl, benzoyl, or cyanide groups. Kinetic studies demonstrate that the overall process consists of two consecutive irreversible reactions: the catalytic metal-promoted monohydroboration of the nitrile to afford the borylimine and the metal-free stoichiometric hydroboration of the latter to give the diborylamine. The mechanism of the hydroboration has been established by combining the kinetic anal. of the catalysis, stoichiometric reactions, and DFT calculations The rate-determining step of the catalysis is the insertion of the C-N triple bond of the nitrile into the Os-B bond of an osmium-σ-borane intermediate and is regiodirected by the nucleophilicity of the nitrogen atom and the electrophilicity of the carbon atom of the nitrile.

Organometallics published new progress about Activation enthalpy. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fukushima, Naoki published the artcileSynthesis of a photocontrollable hydrogen sulfide donor using ketoprofenate photocages, Formula: C16H13NO, the main research area is photocontrollable hydrogen sulfide donor ketoprofenate photocage.

We report the design, synthesis and application of a directly photocontrollable hydrogen sulfide (H2S) donor, which releases H2S proportionally to the intensity and duration of photoirradiation Photocontrolled H2S release from this donor was also demonstrated in bovine serum. This H2S donor should be suitable for use in various biol. systems.

Chemical Communications (Cambridge, United Kingdom) published new progress about Blood serum (bovine). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Formula: C16H13NO.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts