Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 425702-28-9, name is 4,5-Difluoro-2-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 4,5-Difluoro-2-methoxybenzonitrile
Step A: di-fert-Butyl (4-cvano-2-fluoro-5-methoxyphenyl)propanedioate A suspension of NaH (60% in mineral oil, 0.33 g, 8.3 mmol) in dry DMF (20 mL) was stirred and cooled to 0 C, and di-tert-butyl malonate (1.5 g, 7.1 mmol) was added. The mixture was allowed to warm to room temperature before addition of 4, 5-difluoro-2-methoxybenzonitrile (1.0 g, 5.9 mmol). The mixture was heated at 80 C for 4 h with stirring, then the reaction mixture was cooled to room temperature and poured into a mixture of ice-water (100 mL) and AcOEt (100 mL). The layers were separated, and the organic layer was washed successively with water, and brine, then dried over Na2S04 and concentrated. The residue was purified by flash chromatography (silica gel, EtOAc/hexanes, 0 -> 10%) to give the di-tert-butyl (4-cyano-5- fiuoro-2-methoxyphenyl) propanedioate. LCMS: [(M+l)-t-Bu,C02-t-Bu]+ = 210.
The synthetic route of 425702-28-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
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