In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42186-06-1, name is 2-(4-Bromophenyl)propanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-(4-Bromophenyl)propanenitrile
[00820] Example 42. Preparation of N-((6-(3-t°r^butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-2- methoxyphenyl)benzo[c/]isoxazol-3-yl)methyl)methanesulfonamide (compound IB-LO-2.45).; [00821] Part A. Preparation of N-((6-bromobenzo[(f]isoxazol-3-yl)methyl)-N-(4-methoxybenzyl)- methanesulfonamide.; [00822] To a refluxing solution of 6-bromo-3-methylbenzo[d]isoxazole (LOg, 4.72mmol) in CCl4 (25ml) was added l-bromopyrrolidine-2,5-dione (0.923g, 5.19mmol) and benzoic peroxyanhydride (0.114g, 0.472mmol). The mixture was refluxed for 6h, and then cooled to room temperature, filtered thru celite, and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using CH2Cl2 as the eluent to give the dibromide as a solid (0.84g, 43%). To a solution of the dibromide (0.2Og, 0.687mmol) and N-(4-methoxybenzyl)methanesulfonamide (0.148g, 0.687mmol) in EtOH (3ml) was added IN aq. NaOH (0.722ml, 0.722mmol), and the resulting mixture was stirred at 8O0C for 90min. The mixture was partitioned between 0.1nu aq. HCL (1OmL) and EtOAc (2 x 1OmL), and the combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatography on silica gel using 2:3 EtOAc:hexanes as eluent to give the title
The synthetic route of 42186-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts