Category: 420-04-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 420-04-2, name is Cyanamide, A new synthetic method of this compound is introduced below., name: Cyanamide

0.2 mol of the above intermediate and 0.2 mol of 50% monocyanamide aqueous solution were added, stirred uniformly, and 0.1 mol of anhydrous sodium hydrogen phosphate was added under stirring at room temperature to control the reaction temperature not exceeding 40 C, and the reaction time was 4 h, and analyzed by thin layer chromatography. The reaction progress was followed; after the reaction was completed, the filtration was carried out, the filter residue was washed with distilled water, and the washing water and the filtrate were combined, shaken, and allowed to stand for stratification; the aqueous layer was separated, and the aqueous layer was extracted with ethyl acetate three times. The ethyl acetate layer was combined with the oil layer and distilled under reduced pressure at 80 kPa for 2 h. A colorless clarified oil was obtained as the product, ethyl N-cyanoethyl imidate, yield: 95.3%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Zhang Yu; (4 pag.)CN109721509; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 420-04-2, These common heterocyclic compound, 420-04-2, name is Cyanamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1) Ethyl N-cyanoacetoimidate A solution of cyanamide (3.52 g), acetic anhydride (15.7 ml) and triethyl orthoacetate (15.0 ml) was stirred at 140 C. for 2.5 hours. After the reaction, the mixture was distilled under reduced pressure to give 5.29 g of a colorless transparent liquid (yield 58%). Boiling point: 50-60 C./2.5 mmHg IR (KBr): 2990, 2940, 2210, 1700, 1668, 1604 cm-1 1 H-NMR (CDCl3) delta: 1.35 (3H, t, J=7.1 Hz), 2.40 (3H, s), 4.29 (2H, q, J=7.1 Hz)

Statistics shows that Cyanamide is playing an increasingly important role. we look forward to future research findings about 420-04-2.

Reference:
Patent; The Green Cross Corporation; US5750545; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts