Category: 4110-35-4

These common heterocyclic compound, 4110-35-4, name is 3,5-Dinitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H3N3O4

The 3,5-dinitrobenzonitrile (10 g, 0.052 mol), sodium azide(3.97 g, 0.061 mol) and triethylammonium chloride (8.4 g,0.061 mol) were mixed with DMF (50 mL). The reaction mixturewas heated at 100 C for 6 h. Upon completion, the reaction mixturewas filtered, DMF was evaporated, and the residue was dissolved inwater (100 mL). The solutionwas acidified with HCl to pH 1, and theprecipitated product was filtered, washed with water and dried.Yield: 87% as a yellowish solid, mp: 176-177 C (lit. [27]. 178-179 C). 1H NMR (300 MHz, DMSO-d6) delta 9.13 (dd, J =2.1, 0.5 Hz, 2H),8.96 (td, J = 2.1, 0.5 Hz, 1H). 13C NMR (75 MHz, DMSO) delta 154.92,148.92, 128.05, 126.97, 120.40.

The synthetic route of 3,5-Dinitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; N?me?ek, Jan; Sychra, Pavel; Macha?ek, Miloslav; Benkova, Marketa; Karabanovich, Galina; Kone?na, Klara; Kavkova, V?ra; Stola?ikova, Ji?ina; Hrabalek, Alexandr; Vavrova, Kate?ina; Soukup, Ond?ej; Roh, Jaroslav; Klime?ova, V?ra; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 419 – 432;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 4110-35-4, name is 3,5-Dinitrobenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4110-35-4

Example 137Alternative Preparation of 3-(4,5-dihydro-4-methyl-5-oxotetrazol-1-yl)-5-nitrobenzonitrileA mixture of 3,5-dinitrobenzonitrile (386 mg, 2.0 mmol), 1-methyl-1H-tetrazol-5(4H)-one (400 mg, 4.0 mmol) and K2CO3 (552 mg, 4.0 mmol) in NMP (6 mL) was heated to 110 C. and stirred overnight. After allowing to cool, the mixture was poured in to H2O (75 mL) and EtOAc (40 mL). The aqueous and organic layers were partitioned and the aqueous layer was extracted with EtOAc (2¡Á30 mL). The combined organic extracts were washed with brine (1¡Á20 mL), dried (Na2SO4), filtered and the solvent removed under vacuum to leave a crude residue. The residue was purified by column chromatography on silica gel using EtOAc/hexane (3:7 to 4:6) as eluent to give the product (182 mg, 37%) as a solid.Data identical to previously synthesized material. (Example 136)Note: 1-methyl-1H-tetrazol-5(4H)-one was prepared according to procedure detailed in EP643049 (1995); Preparation of 1-substituted-5(4H)-tetrazolinones by desulfurization of tetrazolinethiones, which is hereby incorporated by reference.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4110-35-4, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Singh, Rajinder; Tso, Kin; Zhang, Jing; Duncton, Matthew; Alvarez, Salvador; Kolluri, Rao; Ramphal, John; Holland, Sacha; US2011/130415; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

4110-35-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4110-35-4, name is 3,5-Dinitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1.1.62: 5-(aminomethyl)-Nl, N l,N3,N3-tetramethylbenzene- 1,3 -diamine; 20% Pd(OH)2 (0.13 g) was added to a stirred suspension of 3,5-dinitrobenzonitrile (0.50 g, 2.59 mmol, 1 eq, Aldrich) in 10 ml EtOH. A H2 balloon was added. After stirring over the weekend the mixture was filtered through Celite. The filter cake was rinsed with EtOH (x3). The organics were removed in vacuo. The residue was stirred in CHCl3 and the resulting mixture was filtered (x3). The CHCl3 fractions were combined, and the solvent was removed in vacuo to yield crude 3,5-diaminobenzonitrile.

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4110-35-4 name is 3,5-Dinitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 4110-35-4

(1) Ethyl 3,5-dinitrobenzimidate hydrochloride was synthesised in the same manner as in Reference Example 2. That is, 3,5-dinitrobenzonitrile (25.2 g, 0.130 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 34.5 g (96%) of the target compound as pale-brown crystals.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dinitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; The Green Cross Corporation; US5948785; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts