Category: 4110-35-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4110-35-4 name is 3,5-Dinitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 4110-35-4

(1) Ethyl 3,5-dinitrobenzimidate hydrochloride was synthesised in the same manner as in Reference Example 2. That is, 3,5-dinitrobenzonitrile (25.2 g, 0.130 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 34.5 g (96%) of the target compound as pale-brown crystals.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dinitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; The Green Cross Corporation; US5948785; (1999); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Formula: C7H3N3O4

General procedure: (Caution HMPA is not a friendly solvent). A solution of 0.5 g of a starting substrate in 15 ml of HMPA was kept at 155-160 C until the reactant was consumed (TLC; eluent, CHCl3). The reaction mass was cooled and poured into 150 ml of ice water. The precipitate was filtered off, washed with water and dried. The crude product was dissolved in chloroform, and the solution was filtered through a silica gel bed. The filtrate was evaporated, and the residue was crystallized from methanol.

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dutov, Mikhail D.; Serushkina, Olga V.; Mendeleev Communications; vol. 23; 3; (2013); p. 174 – 175;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4110-35-4, name is 3,5-Dinitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H3N3O4

a. 3,5-Diaminobenzonitrile To a solution of 210 grams of stannous chloride dihydrate in 590 ml. of concentrated hydrochloric acid is added portionwise 25 grams of 3,5-dinitrobenzonitrile. The mixture is stirred for 3 hours at room temperature, then cooled to 0 in an ice-salt bath and a cold 50% sodium hydroxide solution added to the mixture until the mixture is strongly basic. During the addition the temperature is kept below 5. The mixture is extracted with methylene chloride and the solvent removed. There is obtained 2.25 grams of material melting at 185-8. Recrystallization from ethanol raises the melting point to 188-9. Analysis Calcd. for: C7 H7 N3 C, 63.14; H, 5.30; N, 31.56. Found: C, 62.87; H, 5.19; N, 31.72.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4110-35-4.

Reference:
Patent; The Upjohn Company; US3993679; (1976); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4110-35-4, name is 3,5-Dinitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: nitriles-buliding-blocks

1A. Formula 103 where R1 is Pyridin-3-yl and Y is CN [0094] A solution of 1 equivalent (eq., 25.42 g, 131.6 mmol)) of 1,3 dinitro-5-cyanobenzene in 1.75 M DMF (75 mL),1 eq. 3-hydroxypyridine (12.52g, 131.6 mmol) and 2 eq. potassium carbonate (36.38 g, 263 mmol) was heated to 60Covernight. The reaction mixture was warmed to 95C for an additional 48 hours. The reaction mixture was diluted withEtOAc, washed with H2O, sat. NaHCO3, and brine, dried over Na2SO4 and concentrated in vacuo. Purification bychromatography over silica with 25% EtOAC/Hexane as the eluant afforded 10.04g of the desired compound of Formula103, 3-(pyridin-3-yloxy)-5-cyano-1-nitrobenzene, as a solid (32% yield).

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cytokinetics, Inc.; MALIK, Fady; TOMASI, Adam, Lewis; FENG, Bainian; KRAYNACK, Erica, Anne; ELIAS, Kathleen; LU, Pu-Ping; SMITH, Whitney, Walter; QIAN, Xiangping; MORGANS, David, J., Jr.; EP1503986; (2015); B1;,
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4110-35-4, name is 3,5-Dinitrobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

General procedure: The procedure for the synthesis of the tetrazole 2a is representative. A mixture of sodium azide (0.39 g 0.0060 mol), urea (0.36 g, 0.0060 mol) and water (2.5 mL) was taken in a round-bottom flask and stirred at 60 C for 1 h. Charged benzonitrile 1a (0.5 g 0.0048 mol), acetic acid(0.5 mL) and DMF (2.5mL) at 60 C and heat to 110C stirred for 8 h. After completion of the reaction (as indicated by TLC), the reaction mixture was cooled to room temperature and diluted the reaction mass with water (2.5 mL)and ethyl acetate (5.0 mL) at 25-35 C. Add 5N aqueous hydrochloric acid (2.5 mL) at 25-35 C. Stirred for 20- 30 min, the resultant organic layer was separated and the aqueous layer was extracted with ethyl acetate (2.5 mL). The combined organic layer was washed with 40 % aq.NaCl solution (2.5 mL) and dried over anhydrous Na2SO4 and concentrated to give a crude product, which was isolated using chilled water after 3-4 h maintenance, and eventually filtered off to give 0.67 g (95%) of an off-white solid.

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yakambram; Jaya Shree; Srinivasula Reddy; Satyanarayana; Naveen; Bandichhor, Rakeshwar; Tetrahedron Letters; vol. 59; 5; (2018); p. 445 – 449;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Safety of 3,5-Dinitrobenzonitrile

3,5-Dinitrobenzonitrile(1.50 g, 7.77 mmol) was added to a slurry of pyridin-3-ol (739 mg, 7.77 mmol) and potassium carbonate (10.7 g, 77.7 mmol) in DMF (15 mL), the mixture was warmed to 60 C and stirred overnight. After cooling to RT the reaction was diluted with ethyl acetate (50 mL) and water (100 mL). The organic phase was separated, washed with saturated sodium bicarbonate (50 mL) and brine (50 mL), dried ( a2S04), concentrated in vacuo and purified by chromatography (Si-40 column, ethyl acetate/hexanes) to give a light yellow solid identified as 3-nitro-5- (pyridin-3-yloxy)benzonitrile (1.31 g , 69% yield). MS (ESI) m/z: 242.0 (M+H+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Safety of 3,5-Dinitrobenzonitrile

Example 19 – Preparation of 3-Amino-5-[(7-chloroquinolin-4-yl)amino] benzonitrile hydrochloride (compound 73); Step A: 3,5-Diaminobenzonitrile; To 3,5-dinitrobenzonitrile (5.0 g, 25.89 mmol) in 20 mL of HCI 1 M, was added SnCI2 (34.4 g, 7 eq). The reaction mixture was stirred at room temperature for 2h and then cooled to O’C. The mixture was made alkaline with a 50% aqueous solution of NaOH and the precipitate was removed by filtration. The filtrate was extracted with ethyl acetate and the combined organic layers were evaporated. The residue and the precipitate were purified by flash chromatography on silica gel (DCM/MeOH//95/5) to yield expected compound as an orange solid (1 .95 g, 57% yield), m/z (ESI) 134.0 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE LILLE 2 DROIT ET SANTE; DELACOURTE, Andre; MELNYK, Patricia; BURLET, Stephane; LEFUR, Nicolas; WO2011/73322; (2011); A1;,
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Electric Literature of 4110-35-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4110-35-4 as follows.

3,5-dinitro-benzonitrile (3 g, 16 mmol), 6-methylpyridin-3-ol (1.7 g, 16 mmol), and K2CO3 (4.3 g, 31 mmol) were dissolved in DMF and heated to 1 10 C overnight. The reaction mixture was poured into water and the mixture was extracted with EtOAc. The combined organics were washed with brine, dried (Na2S04), concentrated in vacuo and purified by silica gel chromatography to provide 3-(6- methylpyridin-3-yloxy)-5-nitrobenzonitrile (3 g, 76% yield ). FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, DMSO) delta 8.50 (s, 1 H), 8.38 (s, 1 H), 8.08 (s, 1 H), 8.01 (s, 1 H), 7.59-7.56 (d, J = 10 Hz, 1 H), 7.38-7.36 (d, J = 8.4 Hz, 1 H), 1.98 (s, 3 H); MS (ESI) m/z: 256.3 [M+H]+.

According to the analysis of related databases, 4110-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.; WO2013/36232; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3,5-Dinitrobenzonitrile

Preparation 133 A suspension of 3,5-dinitrobenzonitrile (2.75g) in methanol (15ml) and tetrahydrofuran (15ml) was hydrogenated over 10 % palladium on carbon (50% wet) under hydrogen atmosphere for 6 hours. The catalyst was filtered off. The filtrate was concentrated, purified with silica gel column chromatography and eluted with dichloromethane in 0-1% methanol to give 3-cyano-5-nitroaniline (951mg). ESI-mass;m/z162.3(M-H+) 1H-NMR(DMSO-d6): delta;6.33(2H,s), 7.24(1H,s), 7.6-7.8(2H,m)

The synthetic route of 4110-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP1264820; (2002); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 4110-35-4,Some common heterocyclic compound, 4110-35-4, name is 3,5-Dinitrobenzonitrile, molecular formula is C7H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of nitrile (1 mmol), sodium azide (1.5 mmol), Cu complex catalyst (0.4 mol%) and DMF (3 mL) was taken in a round-bottomed flask and stirred at 110 C temperature. After completion of the reaction the catalyst was separated from the reaction mixture with an external magnet and reaction mixture was treated with ethyl acetate (2 ¡Á 20 mL) and 1 N HCl (20 mL). The resultant organic layer was separated and the aqueous layer was again extracted with ethyl acetate (2 ¡Á 15 mL). The combined organic layers were washed with water, concentrated, and the crude material was chromatographed on silica gel (Hexane-EtoAc, 1:1) to afford the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dinitrobenzonitrile, its application will become more common.

Reference:
Article; Esmaeilpour, Mohsen; Javidi, Jaber; Nowroozi Dodeji, Fatemeh; Mokhtari Abarghoui, Mehdi; Journal of Molecular Catalysis A: Chemical; vol. 393; (2014); p. 18 – 29;,
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