Category: 4088-84-0

Application of 4088-84-0, A common heterocyclic compound, 4088-84-0, name is 2-Fluoro-5-trifluoromethylbenzonitrile, molecular formula is C8H3F4N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Fluoro-5-trifluoromethyl-benzonitrile (Matrix, 5.0 g, 26.5 mmol) and hydrazine (Aldrich, 1.28 g, 40 mmol) in IPA (10 mL) were heated to reflux for 2 hours. The solvent was removed to afford the title compound as white solid (5.3 g, 100%). MS: 202 (MH+).

The synthetic route of 4088-84-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Xuqing; Hufnagel, Heather; Hou, Cuifen; Opas, Evan; McKenney, Sandra; Crysler, Carl; O’Neill, John; Johnson, Dana; Sui, Zhihua; Bioorganic and Medicinal Chemistry Letters; vol. 21; 20; (2011); p. 6042 – 6048;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4088-84-0 as follows. HPLC of Formula: C8H3F4N

Heat a solution [OF 2-FLUORO-5-TRIFLUOROMETHYL-BENZONITRILE (L. OG,] 5.74 mmol) with 4,5-difluoro-2-nitro-phenylamine (1.09g, 5.74 mmol) and lithium hydroxide monohydrate (0. [48G,] 11.49 mmol) in DMSO (12 ml) to 55 [C] for 16 hours. Cool the reaction to ambient temperature and then add approximately 150 ml of ice water and stir the mixture for one hour. Extract with three 200 ml portions of dichloromethane. Combine organic layers, dry over sodium sulfate and evaporate solvent. Purify the residue via flash chromatography eluting with a linear gradient starting with 100% hexanes and going to 70% hexanes: 30% ethyl acetate to obtain 0.995g (2.90 mmol, 50% yield) of the title compound as a yellow amorphous solid: Mass Spectrum [(M/E)] : 344 [(M+1).]

According to the analysis of related databases, 4088-84-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14895; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts