Category: 40497-11-8

Related Products of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation 104; 5-amino-1-[2, 6-dichloro-4-(trifluoromethoxy) phenyl]-1 H-pyrazole-3-carbonitrile To sulphuric acid (18M, 54 mi) was added sodium nitrite (13.9 g, 201.2 mmol) and the solution was stirred at 15C for 1 h. To the solution was added acetic acid (200 ml), followed by 2, 6-dichloro-4- (trifluoromethoxy) aniline (45.0 g, 182.9 mmol) in acetic acid (90 ml), ensuring the temperature of the solution did not rise above 20C. After addition was complete, the mixture was heated at 50C for 1 h, cooled to room temperature and added dropwise to a solution of ethyl 2,3-dicyanopropanoate (Hainzl, D.; Cole, L. M. ; Casida, J. E. Chemical Research in Toxicology (1998), 11 (12), 1529-1535,27. 8 g, 182.9 mmol) in acetic acid (115 ml) and ice cold water (145 ml). The reaction mixture was then stirred overnight at room temperature. To the reaction mixture was added dichloromethane (500 mi) and the mixture was stirred for 10 min. The two phases were separated and the organic phase was washed with water (200 mi) and ammonia (0.88, 400 ml) was added dropwise, maintaining the temperature of the mixture below 10C. This mixture was stirred overnight at room temperature and the organic phase was separated and concentrated in vacuo. The residue was re-crystallised from toluene/pentane [2: 1] to give the titled compound (22.4 g). Experimental MH+ 337.0 ; expected 337.0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.

Application of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 2,3-dicyanopropanoate (1.58 g, 10.38 mmol) in methanol (52 mL) and pyridine (2.52 mL, 31.14 mmol) was cooled to 10C with an ice bath. Benzenediazonium tetrafluoroborate was added in portions over 20 minutes at 10C and the reaction stirred at room temperature for 18 hours. The reaction was concentrated in vacuo and partitioned between DCM and water. The organic layer was dried over magnesium sulphate and concentrated in vacuo to afford the title compound (2.8 g, 28%). 1 H NMR (400MHz, CDCI3): delta ppm 3.62 (s, 2H), 7.05-7.25 (m, 3H), 7.36 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.

These common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H8N2O2

Add 0.01 mol of 3-fluoroaniline and a small amount of ethanol to a 250 mL round bottom three-necked flask.Under ice bath, 3.0 mL (0.035 mol) of concentrated hydrochloric acid was added dropwise with stirring.Dissolve 0.018 mol of sodium nitrite in 10 mL of water.Slowly drip into the flask, and after the completion of the dropwise addition, the reaction was carried out for 0.5 h to obtain a yellow diazonium salt solution.Add 0.01 mol of ethyl 2,3-dicyanopropionate to a three-necked flask.The prepared diazonium salt solution was dropped into the flask, and the reaction was added dropwise for 2 hours.Ammonia water was added, the pH was adjusted to 9-10, and the reaction was carried out for 2 h at room temperature.After the reaction was completed, it was extracted with 40 mL of dichloromethane, and the organic layer was washed with water (2¡Á30 mL).Wash with saturated sodium chloride solution (1¡Á40 mL), dry over anhydrous magnesium sulfate.The solvent was crystallized under reduced pressure to give the product 1.18 g,yield: 58.3%,

The synthetic route of Ethyl 2,3-dicyanopropanoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Tech University; Wan Rong; Chen Fuli; Han Zhenyu; Fu Xiaohuan; Jiang Peng; (17 pag.)CN108203450; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 40497-11-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40497-11-8, name is Ethyl 2,3-dicyanopropanoate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Into a 500 ml three-necked glass bottle, 30.4 g (0.2 mol) of ethyl 2,3-dicyanopropionate (1E) and 300 g of water were sequentially added.The temperature of the reaction solution was lowered to 0 10 with stirring;Add 32g (0.2mol) bromine (Br2) to the reaction solution dropwise, and control the drop rate so that the solution temperature does not exceed 10 ;At the end of the dropwise addition, continue to hold at 0-10 C and stir the reaction for 4h.Then, let stand and dispense. Sampling the organic layer for gas chromatography analysis,The results showed that the content of ethyl 2-bromo-2,3-dicyanopropionate (1F), the target product of this reaction, was 91.22%, and it could be directly put into the next reaction.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2,3-dicyanopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Shi Haibing; Song Qifa; Cai Yichao; (8 pag.)CN111004250; (2020); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl 2,3-dicyanopropanoate

Example 11Preparation of 5-aminopyrazole (VII):; To 2,6-dichloro-4-trifluoromethyl aniline 230 g and acetic acid 150 ml was added 1.1m of nitrosyl sulphuric acid over one hour at 30C and maintained at 30C for one more hour. Heat the mass to 50-55C over ? hour and the absence of 2,6-dichloro-4-trifluoromethyl aniline was monitored. Cool the mass to 30C, and the excess nitrosyl sulphuric acid was destroyed.The above diazotized mass was added to a mixture of 250 ml of acetic acid, 162 g ethyl-2,3-dicyanoproprionate and 425 ml water over 4-5 hours maintaining temperature 0-5C. Further maintained at 0C / 2 hours, 5C / 1 hour, 10C / lhour, 15C / 1 hour. 800 ml water was added at 15C over ? hour, extracted the solution with 3×250 ml methylene dichloride. Layers were separated. Dichloromethane layer was washed with 250 ml water, cooled the dichloromethane layer to 0C and washed with 250 ml 8N aq. NH3 under stirring for one hour. Layers were separated, dichloromethane layer was taken and NH3 gas was passed at 0-5 C till free NH3 was observed on top of the condenser and maintained the reaction mass for 3-4 hours at 0-5C. Then 250 ml water was added, stirred for ? hour, layers were separated, extracted aq. layer with 2×100 ml dichloromethane, dichloromethane layer was dried with MgS04, dichloromethane layer was concentrated to dryness, to obtain 288 g of 5-amino-3-cyano-l-(2,6- dichloro-4-triflouromethyl phenyl)-pyrazole of 98% purity.

The synthetic route of 40497-11-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GHARDA, Keki Hormusji; WO2011/107998; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40497-11-8, Application In Synthesis of Ethyl 2,3-dicyanopropanoate

In a 250 mL round bottom three-necked flask, 0.01 mol of 2-methylaniline and a small amount of ethanol were added,3.0 mL (0.035 mol) of concentrated hydrochloric acid was added dropwise under ice-cooling with stirring.0.018 mol of sodium nitrite was dissolved in 10 mL of water,Slowly drop into the flask, drop finishedAfter reaction 0.5h yellow diazonium salt solution.0.01 mol of ethyl 2,3-dicyanopropionate was added to a three-necked flask,The prepared diazonium salt solution was dropped into the flask,After dropping the reaction for 2 h.Adding ammonia,Adjust the pH to 9-10,Reaction at room temperature for 2h.After completion of the reaction, the reaction mixture was extracted with 40 mL of dichloromethane,The organic layer was washed with water (2 x 30 mL)Washed with saturated sodium chloride solution (1 x 40 mL)Dried over anhydrous magnesium sulfate,A portion of the solvent was evaporated under reduced pressure to crystallize 1.30 g of product,Yield 66.7%

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Nanjing University of Technology; Wan, Rong; Wu, Shaohua; Guo, Chunwei; Wang, Xinlin; Chen, Fuli; Han, Zhenyu; Fu, Xiaohuan; (13 pag.)CN105820167; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 40497-11-8, A common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 0.01 mol of 3-bromoaniline and a small amount of ethanol to a 250 mL round bottom three-necked flask.Under ice bath, 3.0 mL (0.035 mol) of concentrated hydrochloric acid was added dropwise with stirring.Dissolve 0.018 mol of sodium nitrite in 10 mL of water and slowly drip into the flask.After the completion of the dropwise addition, the reaction was carried out for 0.5 h to obtain a yellow diazonium salt solution.Add 0.01 mol of ethyl 2,3-dicyanopropionate to a three-necked flask.The prepared diazonium salt solution was dropped into the flask, and the reaction was added dropwise for 2 hours.Ammonia water was added, the pH was adjusted to 9-10, and the reaction was carried out for 2 h at room temperature.After completion of the reaction, the mixture was extracted with 40 mL of dichloromethane, and the organic layer was washed with water (2¡Á30 mL), and washed with a saturated sodium chloride solution (1¡Á40 mL), dried over anhydrous magnesium sulfate, and evaporated under reduced pressure. Yield 70.1%,

The synthetic route of 40497-11-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Tech University; Wan Rong; Chen Fuli; Han Zhenyu; Fu Xiaohuan; Jiang Peng; (17 pag.)CN108203450; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 40497-11-8,Some common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.01 mol of ethyl 2,3-dicyanopropionate was added to a three-necked flask. The prepared diazonium salt solution was dropped into the flask. The reaction was complete for 2 h. Adding aqueous ammonia, adjust the pH to 9-10. Reaction at room temperature for 2h. After completion of the reaction, the reaction mixture was extracted with 40 mL of dichloromethane. The organic layer was washed with water (2 x 30 mL), washed with saturated sodium chloride solution (1 x 40 mL), and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 1.18 g of product, yield 53.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2,3-dicyanopropanoate, its application will become more common.

Reference:
Patent; Nanjing University of Technology; Wan, Rong; Wu, Shaohua; Guo, Chunwei; Guan, Xilin; Chen, Fuli; Han, Zhenyu; Fu, Xiaohuan; (14 pag.)CN105601632; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 40497-11-8, A common heterocyclic compound, 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

250 mL round bottom three-necked flask0.01 mol of 4-methylaniline and a small amount of ethanol,3.0 mL (0.035 mol) of concentrated hydrochloric acid was added dropwise under ice-cooling with stirring.0.018 mol of sodium nitrite was dissolved in 10 mL of water,Slowly dropping into the flask,After the reaction was completed 0.5h yellow diazonium salt solution.0.01 mol of ethyl 2,3-dicyanopropionate was added to a three-necked flask,The prepared diazonium salt solution was dropped into the flask,After dropping the reaction 2 h. Adding ammonia,Adjust the pH to 9-10,Reaction at room temperature for 2h.After completion of the reaction, the reaction mixture was extracted with 40 mL of dichloromethane,The organic layer was washed with water (2 x 30 mL)Washed with saturated sodium chloride solution (1 x 40 mL)Dried over anhydrous magnesium sulfate,A portion of the solvent was evaporated under reduced pressure to crystallize to yield 1.20 g of product,Yield 60.5%

The synthetic route of 40497-11-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing University of Technology; Wan, Rong; Wu, Shaohua; Guo, Chunwei; Wang, Xinlin; Chen, Fuli; Han, Zhenyu; Fu, Xiaohuan; (13 pag.)CN105820167; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding some certain compound to certain chemical reactions, such as: 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40497-11-8. 40497-11-8

Ethyl 2,3-dicyanopropionate (1.0 mmol) was added to 20.0 ml of ethanol, vigorously stirred., then Hydrazine hydrate (2.0 mmol) was added to the reaction solution, and the mixture was heated under reflux for 3 hours. The heating was stopped and the mixture was cooled to room temperature. The mixture was concentrated in vacuo and the mixture was extracted with ethyl acetate and water. The resulting ethyl acetatewas extracted andconcentrated in vacuo to give 5-amino-1H-pyrazole-3-cyano as a white solid. The intermediate was used directly in the next step without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Ethyl 2,3-dicyanopropanoate.

Reference:
Patent; South China Agricultural University; Xu Hanhong; Jiang Xunyuan; Wei Xiaoyi; Zhang Zhixiang; Lin Fei; Yao Guangkai; Deng Chengju; (50 pag.)CN108003162; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts