Category: 403-54-3

403-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 3-methylbenzonitrile (5 mmol), benzyl acetate (6mmol), and Fe(ClO4)3¡¤H2O (5 mol%) was placed in a round-bottomedflask. Then, the reaction mixture was heated at 80 C for5 h. After completion of the reaction monitored by thin layerchromatography (TLC), water (10 mL) was added, and the reactionmixture was extracted with ethyl acetate (3 ¡Á 20 mL). Theorganic layers were collected, combined, washed with water (3¡Á 20 mL), dried with anhydrous Na2SO4, and concentrated undervacuum. The pure product was obtained by directly passingthrough a silica gel (200-300 mesh) column to give a whitepowder n (0.96 g, 86% yield)..

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Reference:
Article; Feng, Chengliang; Yan, Bin; Yin, Guibo; Chen, Junqing; Ji, Min; Synlett; vol. 29; 17; (2018); p. 2257 – 2264;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., 403-54-3

a. 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5 * 250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Rohm and Haas Company; US4063929; (1977); A;; ; Patent; Rohm and Haas Company; US4093446; (1978); A;; ; Patent; Rohm and Haas Company; US4046798; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 403-54-3 name is 3-Fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 403-54-3

(a) 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mol) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5*250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Rohm and Haas Company; US4330324; (1982); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts