Category: 403-54-3

Related Products of 403-54-3, The chemical industry reduces the impact on the environment during synthesis 403-54-3, name is 3-Fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

A solution of 3-F-benzonitrile (8.2 g, 68 mmol) and N-methylpiperazine (41.5 mL, 374 mmol) in anhydrous DMSO (60 mL) was warmed at 100 C. with stirring for 28 h. After cooling the reaction mixture was poured into water (600 mL) and was extracted with diethylether (3¡Á500 mL). The organic phase was washed with brine, dried over sodium sulfate and concentrated to give 3-(4-methylpiperazin-1-yl)benzonitrile as an oil (10.3 g, 51.2 mmol, 75%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pharmacia Italia S.p.A.; US2007/112020; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

403-54-3, name is 3-Fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Fluorobenzonitrile

REFERENCE EXAMPLE 20 3-(4-Methyl-1-piperazinyl)benzonitrile According to a similar manner to that in Reference Example 17, the title compound was synthesised from 3-fluorobenzonitrile and 1-methylpiperazine. 1 H-NMR (CDCl3) delta (ppm): 2.35(3H, s), 2.55-2.60(4H, m), 3.21-3.25(4H, m), 7.06-7.13(3H, m), 7.28-7.31(1H, m).

The synthetic route of 403-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyowa Hakko Kogyo Co., Ltd.; US6127541; (2000); A;,
Nitrile – Wikipedia,
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Application of 403-54-3, A common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 3-fluorobenzonitrile (70; 20.0 g, 165 mmol) and EtOH (50 m L) and was cooled with an ice-bath. HC1 gas was bubbled through the solution unti l saturation and the reaction mixture was stirred overnight. The solid was col lected by filtration and was washed with cold ether to obtain ethyl-3-fluorobenzimidate hydrochloride as a solid (71 ; 33.5 g, 99% yield). MS (ESI) calcd for C9H,0FNO-HC1: 203.64.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H4FN

To a mixture of 3-fluoro- benzonitrile 43b (1.0 g, 8. 25 MMOL) and K2CO3 (2.27 mg, 16.51 MMOL) in dimethyl sulfoxide (7 mL) was added 1-benzyl piperazine (2. 14 mL, 12. 38 MMOL) and the reaction continued as described above to afford amine 199 g of 49b in 87% YIELDS. 1H-NMR (500 MHz, CDCI3) : 2. 65 (4Hs, t, J = 5.12 Hz), 3.27 (4Hs, t, J = 5.12 Hz), 3.61 (2Hs, s), 7.11-7. 15 (3Hs, m), 7.31-7. 41 (6Hs, m); ESI- MASS: 300.5 (M+23).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 403-54-3, its application will become more common.

Reference:
Patent; THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; COLORADO STATE UNIVERSITY RESEARCH FOUNDATION; WO2005/7625; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 403-54-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 403-54-3 as follows.

General procedure: A mixture of nitriles (5 mmol), methyl ethers (6 mmol) and Fe(ClO4)3¡¤H2O (5%mol) was placed in a round bottom flask. Then the reaction mixture was heated at 100 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), 10 ml water was added into reaction system and extracted with ethyl acetate (3 ¡Á 20 ml). The organic layers were collected, combined, washed with water (3 ¡Á 20 ml), dried over anhydrous Na2SO4, and concentrated under vacuum. The pure products (1a-1k and 2a-2p) were obtained by directly passing through a silica gel (200-300 mesh) column using petroleum ether/ethyl acetate (10:1-5:1).

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yin, Guibo; Yan, Bin; Chen, Junqing; Ji, Min; Journal of the Iranian Chemical Society; vol. 16; 6; (2019); p. 1355 – 1363;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 403-54-3, name is 3-Fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 403-54-3, Recommanded Product: 3-Fluorobenzonitrile

3-(4-Benzyl-piperazin-1-yl)-benzonitrile (49b). To a mixture of 3-fluoro-benzonitrile 43b (1.0 g, 8.25 mmol) and K2CO3 (2.27 mg, 16.51 mmol) in dimethyl sulfoxide (7 mL) was added 1-benzyl piperazine (2.14 mL, 12.38 mmol) and the reaction continued as described above to afford amine 199 g of 49b in 87% yields. 1H-NMR (500 MHz, CDCl3): delta 2.65 (4Hs, t, J=5.12 Hz), 3.27 (4Hs, t, J=5.12 Hz), 3.61 (2Hs, s), 7.11-7.15 (3Hs, m), 7.31-7.41 (6Hs, m); ESI-MASS: 300.5 (M+23).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; University of Tennessee Research Foundation; US2005/222408; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 403-54-3,Some common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5*250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Fluorobenzonitrile, its application will become more common.

Reference:
Patent; Rohm and Haas Company; US4358308; (1982); A;; ; Patent; Rohm and Haas Company; US4419122; (1983); A;; ; Patent; Rohm and Haas Company; US4419123; (1983); A;; ; Patent; Rohm and Haas Company; US4419124; (1983); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 403-54-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 403-54-3 as follows.

4.12 mL (8.24 mmol) of trimethyl aluminum (2.0 M toluene solution) was added to a 10 mL of toluene containing 441 mg (8.24 mmol) of ammonium chloride at room temperature. After stirring for 1.5 hours, 2 g (28.9 mmol) of isobutyronitrile was added EPO thereto and the resulting mixture was heated to 85C for 9 hours. After completion of a reaction, the reaction solution was poured into 200 mL of chloroform containing 200 g of silicagel and filtered off. The residue was washed with 100 mL of methanol and distillation was conducted to give 731 mg (5.29 mmol) of the title compound in a yield of 64%.[936] NMR: 1H-NMR(CD OD) delta 7.71~7.44(4H, m)[937] Mass(EI) 139(M++.)

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2006/104356; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H4FN

General procedure: CAUTION: Zn(ClO4)2.6H2O can cause skin and serious eye irritation and appropriate care should be taken in its use. In general, perchlorates are explosive compounds and appropriate caution should be taken including the avoidance of evaporation to dryness of perchlorate-containing residues. A mixture of the nitrile (1 mmol), halohydrocarbon (1.2 mmol) and Zn(ClO4)2¡¤6H2O (5 mol%) was placed in a round-bottom flask. Then the reaction mixture was heated at 80 C for the given time. After completion of the reaction (monitored by TLC), water (5mL) was added to the reaction mixture which was then extracted with ethyl acetate (3 ¡Á 5 mL). The organic layers were collected, combined, washed with water (3 ¡Á 10 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The pure product was obtained by passing the organic extract through a silica gel (200-300 mesh) column using petroleum ether (60-90 C)/ethyl acetate (10:1-5:1) as eluent and identified by 1H NMR and 13C NMR. The 1H NMR and 13C NMR spectra of the products are shown in the Electronic Supplementary Information.

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.

Reference:
Article; Feng, Chengliang; Yin, Guibo; Yan, Bin; Chen, Junqing; Ji, Min; Journal of Chemical Research; vol. 42; 7; (2018); p. 383 – 386;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

403-54-3, Adding some certain compound to certain chemical reactions, such as: 403-54-3, name is 3-Fluorobenzonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 403-54-3.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 403-54-3.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts