Category: 403-54-3

Adding a certain compound to certain chemical reactions, such as: 403-54-3, name is 3-Fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 403-54-3, SDS of cas: 403-54-3

a. 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5*250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Rohm and Haas Company; US31455; (1983); E1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

403-54-3, name is 3-Fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C7H4FN

REFERENCE EXAMPLE 20 3-(4-Methyl-1-piperazinyl)benzonitrile By using the same method as described in Reference Example 17, the subject compound is synthesised from 3-fluorobenzonitrile and 1-methylpiperazine. 1H-NMR (CDCl3) delta (ppm): 2.35 (3H, s), 2.55-2.60 (4H, m), 3.21-3.25 (4H, m), 7.06-7.13 (3H, m), 7.28-7.31 (1H, m).

The synthetic route of 403-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pamukeu, Rifat; Piazza, Gary A.; US2002/193389; (2002); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H4FN

(a) 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5*250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

The synthetic route of 3-Fluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rohm and Haas Company; US4358308; (1982); A;; ; Patent; Rohm and Haas Company; US4419122; (1983); A;; ; Patent; Rohm and Haas Company; US4419123; (1983); A;; ; Patent; Rohm and Haas Company; US4419124; (1983); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 403-54-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 403-54-3 name is 3-Fluorobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 3-fluorobenzonitrile (1 g, 8.26 mmol) in ethanol (12 mL) was cooled to 0-5 C. HCl (gas) was bubbled through the mixture until saturation and the mixture was stirred at RT for 16 h. All volatiles were removed and to the residue was added diethyl ether (20 mL). The obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as colorless solid (1.57 g, 7.71 mmol, 93.4% yield). MS: M=168.2 (M-HCl+H)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Bachmann, Stephan; Flohr, Alexander; Zbinden, Katrin Groebke; Koerner, Matthias; Kuhn, Bernd; Peters, Jens-Uwe; Rudolph, Markus; US2013/59833; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 403-54-3, These common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of nitrile (10 mmol), halohydrocarbons (11 mmol) and FeCl2·4H2O (2 mol %) was placed in a round bottom flask. Then the reaction mixture was heated at 80 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), 5 ml water was added into reaction system and extracted with ethyl acetate (3 × 5 ml). The organic layers were collected, combined, washed with water (3 × 10 ml), dried over anhydrous Na2SO4, and concentrated under vacuum. The pure product was obtained by directly passing through a silica gel (200-300 mesh) column using petroleum ether/ethyl acetate and identified by 1HNMR and 13C NMR.

Statistics shows that 3-Fluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 403-54-3.

Reference:
Article; Feng, Cheng-Liang; Yin, Gui-Bo; Yan, Bin; Chen, Jun-Qing; Ji, Min; Chemical Papers; vol. 73; 2; (2019); p. 345 – 353;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 403-54-3,Some common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Benzonitrile 1a (1 mmol), Na2S*9H2O (1.2 mmol) and DMF (1 mL) were added into a 10 mL bottle. The reactor was placed in a heating magnetic stirrer at 130 C. After 2.5 h, by adding about 3 mL H2O after the reaction to disperse the solid product, the reaction mixture was extracted with EtOAc (3 x 3 mL), and the mixture was purified by column chromatography.

The synthetic route of 403-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Cao, Xian Ting; Yang, Huiyong; Zheng, Hui; Zhang, Pengfei; Heterocycles; vol. 96; 3; (2018); p. 509 – 517;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 403-54-3, name is 3-Fluorobenzonitrile, molecular formula is C7H4FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H4FN

The 4chloro-6-(2-methylimidazol-1-yl)quinazoline used as a starting material was obtained as follows: 3-Fluorobenzonitrile (25 g) was added dropwise to a stirred mixture of potassium nitrate (21.1 g) and concentrated sulphuric acid (150 ml) which had been cooled in a mixture of salt and ice. The mixture was stirred at ambient temperature for 45 minutes. The mixture was poured onto ice (800 ml) and the precipitate was isolated. The solid so obtained was dissolved in methylene chloride, dried (MgSO4) and the solution was evaporated to give 5-fluoro-2-nitrobenzonitrile (19 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 403-54-3, its application will become more common.

Reference:
Patent; Zeneca Limited; US5955464; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 403-54-3, name is 3-Fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 403-54-3, Product Details of 403-54-3

a. 3-Cyano-4-nitrofluorobenzene m-Fluorobenzonitrile (96.8 g., 0.8 mole) is added in two and one-half hours to a mixture of concentrated sulfuric acid (600 ml.) and potassium nitrate (80.9 g., 0.8 mole) at 3-6 C., then allowed to warm to 25 C. The mixture is poured over cracked ice (3000 ml.), extracted with chloroform (5*250 ml.), dried and the solvent removed. The residue is extracted with pentane and dried to give 3-cyano-4-nitrofluorobenzene (115 g., 86.5%) m.p. 102-104 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluorobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Rohm and Haas Company; US31455; (1983); E1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 403-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of nitrile (5 mmol), tert-butyl benzoate (5.5 mmol) and Zn(ClO4)2·6H2O (2 mol%) was placed in around bottom flask. Then, the reaction mixture was heated at 50 C for the given time. After completion of the reaction monitored by thin layer chromatography (TLC), the reaction mixture was quenched with 5-ml water. Then the reaction system was added 10 ml aqueous NaOH solution (1 mol/L) and continued to be stirred 5 min and extracted with ethyl acetate (3 × 10 ml). The organic layers were collected, combined, washed with water (3 × 10 ml), driedover anhydrous Na2SO4, and concentrated under vacuum.

The chemical industry reduces the impact on the environment during synthesis 3-Fluorobenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Feng, Cheng-Liang; Yan, Bin; Zhang, Min; Chen, Jun-Qing; Ji, Min; Chemical Papers; vol. 73; 2; (2019); p. 535 – 542;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 403-54-3, name is 3-Fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C7H4FN

Example 19.1 : 3-Fluoro-N-hydroxy-benzamidine3-Fluorobenzonitrile (2.5 g, 0.021 mol), diisopropylethyl amine (10.8 mL, 0.062 mol) and hydroxylamine hydrochloride (4.3 g, 0.062 mol) were mixed in ethanol (30 mL). The reaction mixture was stirred at 70 0C overnight. The reaction mixture was cooled to room temperature and concentrated to half the original volume. The residue was added to a mixture of dichloromethane (200 mL) and water (60 mL). The mixture was basified to pH 9 using 2N NaOH and the organic phase was separated. The aqueous phase was extracted further with dichloromethane (2 x 50 mL) and the combined organic phase was washed with water (75 mL), washed with brine (75 mL), dried over sodium sulfate and concentrated to give the product as a yellow solid (2.8 g, 89 %). 1H NMR (300 MHz, CDCI3): delta 8.05 (bs, 1 H), 7.39 (m, 3H), 7.16 (m, 1 H), 4.88 (bs, 2H).

According to the analysis of related databases, 403-54-3, the application of this compound in the production field has become more and more popular.