Category: 39786-34-0

These common heterocyclic compound, 39786-34-0, name is Ethyl 2-(2-cyanophenoxy)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 2-(2-cyanophenoxy)acetate

To a 1000 mL flask 50.0 g (244 mmol) of the intermediate product (L-1) was added, stirred and 6.43 g (268 mmol) of sodium hydride in 500 ml of DMF (dimethylformamide) are added slowly at 0C. The reaction was allowed to proceed to room temperature for 10 hours. After confirming the completion of the reaction by TLC, 500 mL of dichloromethane and 2000 mL of distilled water were injected to separate the organic layer, and concentrated under reduced pressure to obtain 37.0 g (yield 64%) of intermediate L-2.

The synthetic route of Ethyl 2-(2-cyanophenoxy)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHEIL INDUSTRIES INC.; JEONG, SOO-YOUNG; YU, EUN-SUN; KANG, DONG-MIN; SHIN, JI-HUN; RYU, DONG-KYU; LEE, SANG-SHIN; LEE, HAN-IL; JANG, YU-NA; HAN, SU-JIN; HONG, JIN-SEOK; (35 pag.)KR2015/17817; (2015); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 39786-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39786-34-0, name is Ethyl 2-(2-cyanophenoxy)acetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a 2000-mL round-bottom flask was placed a solution of KOtBu (18 g,160.41 mmol) in THF (600 mL) then a THF solution (400 mL) solution of ethyl 2-(2-cyanophenoxy)acetate (20 g,97.46 mmol,as prepared in the previous step) was added dropwise with stirring. After completion of addition,the reaction wasstirred at rt for 2 h,quenched by the addition of water,and extracted with EtOAc (3×200 mL).The organic extracts were combined,washed with brine (2×200 mL),dried over anhydrousNa2SO4,and concentrated under reduced pressure affording 17 g of the title compound as ayellow solid. Mass Spectrum (LCMS,ESI pos): Calcd. for C,,H,2NO3: 206.1 (M+H); Found:206.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-(2-cyanophenoxy)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PROTEOSTASIS THERAPEUTICS, INC.; MUNOZ, Benito; BASTOS, Cecilia, M.; PARKS, Daniel; KOMBO, David; (301 pag.)WO2017/62581; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts