Category: 39581-21-0

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39581-21-0, name is N-Butyl-2-cyano-acetamide, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 39581-21-0

Exemplary Synthesis 9 Method of Synthesizing Exemplary Compound 9 (0236) (0237) Intermediate 3 (5.0 g), N-butyl-2-cianoacetamide (2.1 g), triethylamine (1.3 g) and acetonitrile (50 ml) were placed in a flask, and the content was stirred at 50 C. for 5 hours. Acetonitrile was removed, the residue was purified by column chromatography, and the eluate was recrystallized from ethanol to obtain a target product. The crystal was dried at 50 C. under air flow, to obtain 1.4 g of Exemplary Compound 9. (0238) lambdamax=369 nm (AcOEt) (0239) 1H-NMR (CDCl3) delta: 8.30 (d, 1H), 5.96 (s, 1H), 4.84 (d, 2H), 4.18 (s, 2H), 3.32 (q, 2H), 2.83 (s, 3H), 1.51 (m, 2H), 1.36 (m, 2H), 1.33 (s, 6H), 0.92 (t, 3H)

According to the analysis of related databases, 39581-21-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM CORPORATION; NORIZUKI, Yutaro; WATANABE, Yukie; TAKAHASHI, Kazutaka; (21 pag.)US2016/16919; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39581-21-0, name is N-Butyl-2-cyano-acetamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H12N2O

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mekheimer, Ramadan Ahmed; Al-Sheikh, Mariam Abdullah; Medrasi, Hanadi Yousef; Alsofyani, Najla Hosain Hassan; Molecules; vol. 23; 3; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 39581-21-0,Some common heterocyclic compound, 39581-21-0, name is N-Butyl-2-cyano-acetamide, molecular formula is C7H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Butyl-2-cyano-acetamide, its application will become more common.

Reference:
Article; Mekheimer, Ramadan Ahmed; Al-Sheikh, Mariam Abdullah; Medrasi, Hanadi Yousef; Alsofyani, Najla Hosain Hassan; Molecules; vol. 23; 3; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 39581-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39581-21-0, name is N-Butyl-2-cyano-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The synthetic route of N-Butyl-2-cyano-acetamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mekheimer, Ramadan Ahmed; Al-Sheikh, Mariam Abdullah; Medrasi, Hanadi Yousef; Alsofyani, Najla Hosain Hassan; Molecules; vol. 23; 3; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 39581-21-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39581-21-0 name is N-Butyl-2-cyano-acetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture ofan aromatic aldehyde 1a-1f (1 mmol) with N-butyl-2-cyanoacetamide 2 (1 mmol) in ethanol (5 mL) wasrefluxed for 2 h, after which phthalhydrazide 3(1 mmol) was added to the mixture and refluxingcontinued for 3 h more. Upon completion of theprocess, according to TLC, the mixture was cooled toroom temperature and the precipitate was filtered off.The crude product was crystallized from ethanol togive the respective compound 4a-4f.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Butyl-2-cyano-acetamide, and friends who are interested can also refer to it.

Reference:
Article; Elmi-Mehr; Davoodnia; Pordel; Russian Journal of General Chemistry; vol. 88; 12; (2018); p. 2595 – 2600;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 39581-21-0, The chemical industry reduces the impact on the environment during synthesis 39581-21-0, name is N-Butyl-2-cyano-acetamide, I believe this compound will play a more active role in future production and life.

Example 11. Synthesis of 1,5-dibutyl-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (AA11) [Show Image] Under the nitrogen gas atomosphere, a mixture of 28% sodium methoxide methanol solution (39 mL, 202 mmol) and ether (260 mL) was cooled to 3C in an ice bath, and the mixture of 2-heptanone (22.84 g, 200 mmol) and ethyl formate (16.15 g, 218 mmol) was dropped in about 20 minutes. After that, being stirred at the same temperature for 30 minutes, then the mixture was returned to be at room temperature and was further stirred for 20 hours afterwards. The precipitated product was removed by filtration and washed enough with ether (about 620 g). The mother liquor and the washing layer were combined and concentrated to give a crude product of 29.34 g. This crude product was repeatedly washed with hexane and ether, and powdered yellow ocher sodium salt of 3-[1-hydroxymethylidyne]-heptan-2-one (11.33 g, 34.5%) was obtained. This salt (2.13 g, 13 mmol) was suspended in DMF (10 mL), and n-butylcyanoacetamide (1.40 g, 10mmol), acetic acid (0.75 mL, 13.1 mmol), piperidine (0.20 mL, 2.02 mmol) were added in order at room temperature, and the mixture was refluxed at 135C for 7 hours. After that, the reaction mixture was let alone at room temperature for 13 hours and then poured into ice water, and the obtained mixture was extracted with ethyl acetate two times. The organic layer was washed with diluted hydrochloric acid one time and with water two times, and then died with anhydrous magnesium sulfare. The solvent was removed by distillation under reduced pressure, and a red oily crude product of 2.03 g was obtained. This crude product was refined by the silica gel chromatography, and the desired 1, 5-dibutyl-6-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile (AA11, 420 mg, 17.3%) and 1-butyl-2-oxo-6-pentyl-1,2-dihydropyridine-3-carbonitrile (230 mg, 9.4%) were obtained. AA11 NMR:(CDC13) 0.95 (t, 3H, J=6.9, 0.98 (t, 3H, J=6.9), 1:5-1.7 (m, 8H), 2.42 (s, 3H), ca 2.4 (m, 2H), 4.08 (2H, m), 7.57 (1H, s)) 1-butyl-2-oxo-6-pentyl-1,2-dihydropyridine-3-carbonitrile NMR: (CDCl3) 0.94 (t, 3H, J=6.8), 0.98 (t, 3H, J=7.2), 1.3-1.7 (m, 10H), 2.66 (m, 2H), 4.04 (m, 2H), 6.11 (ABd, 1H, J=7.5), 7.67 (ABd, 1H, J=7.5)) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Butyl-2-cyano-acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SHIONOGI & CO., LTD.; EP1806342; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39581-21-0 as follows. Recommanded Product: N-Butyl-2-cyano-acetamide

General procedure: A mixture ofan aromatic aldehyde 1a-1f (1 mmol) with N-butyl-2-cyanoacetamide 2 (1 mmol) in ethanol (5 mL) wasrefluxed for 2 h, after which phthalhydrazide 3(1 mmol) was added to the mixture and refluxingcontinued for 3 h more. Upon completion of theprocess, according to TLC, the mixture was cooled toroom temperature and the precipitate was filtered off.The crude product was crystallized from ethanol togive the respective compound 4a-4f.

According to the analysis of related databases, 39581-21-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Elmi-Mehr; Davoodnia; Pordel; Russian Journal of General Chemistry; vol. 88; 12; (2018); p. 2595 – 2600;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 39581-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39581-21-0, name is N-Butyl-2-cyano-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The synthetic route of N-Butyl-2-cyano-acetamide has been constantly updated, and we look forward to future research findings.

Related Products of 39581-21-0, The chemical industry reduces the impact on the environment during synthesis 39581-21-0, name is N-Butyl-2-cyano-acetamide, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of the cyanoacetamide (2.0mmol) in EtOH (3mL), the ketone or aldehyde (2.0mmol) was added and dissolved. Then, triethylamine (Et3N) (2.0mmol) and S8 (0.25mmol) were added and the reaction mixture was refluxed overnight. Afterwards, it was diluted with EtOAc (25mL) and washed with water (2¡Á25mL) and brine (2¡Á25mL). The combined organic layers were dried over MgSO4, filtrated and the solvent was removed under reduced pressure. Further purification by flash chromatography, with heptane:EtOAc 3:1 (v/v) as eluent, was performed when needed.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Butyl-2-cyano-acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Eleftheriadis, Nikolaos; Poelman, Hessel; Leus, Niek G.J.; Honrath, Birgit; Neochoritis, Constantinos G.; Dolga, Amalia; Doemling, Alexander; Dekker, Frank J.; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 786 – 801;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39581-21-0, name is N-Butyl-2-cyano-acetamide, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

General procedure: A mixture of a salicylaldehyde (1a or 1b, 1 mmol), N-alkyl-2-cyanoacetamides (2a-2f,1 mmol), and {Mo132} (0.05 g) was heated in an oil bath at 110 C for 5-15 min. Aftercompletion of the reaction, monitored by TLC on silica gel (n-hexane-ethyl acetate,3:2), the mixture was cooled to room temperature and hot ethanol (10 ml) was added.The catalyst was collected by filtration and washed with a small portion of hot ethanol(5 ml). The combined filtrate was concentrated by half and allowed to stand at roomtemperature. The precipitated solid was collected by filtration, and recrystallized from96% ethanol to give compounds 3a-3i in high yields (see Table 2).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jooya, Arsalan; Davoodnia, Abolghasem; Fattahi, Mehri; Tavakoli-Hoseini, Niloofar; Organic Preparations and Procedures International; vol. 50; 6; (2018); p. 565 – 574;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts