Share a compound : 2-Chloro-5-fluorophenylacetonitrile

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5-fluorophenylacetonitrile, its application will become more common.

Electric Literature of 395675-23-7,Some common heterocyclic compound, 395675-23-7, name is 2-Chloro-5-fluorophenylacetonitrile, molecular formula is C8H5ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0591] To a solution of (2-chloro-5-fluorophenyl)acetonitrile (10.0 g, 59.0 mmol) in THF (75 ml) under argon was added gradually while stirring, at -78C., a 2 M solution of LDA in THF (44 ml, 88 mmol). The mixture was allowed to come to 0C. and, after 15 min, cooled back down again to -78C. Subsequently, tert-butyl 3-bromopropanoate (11 ml, 71 mmol) was slowly added dropwise thereto at -78C. while stirring. Stirring of the mixture was continued overnight, in the course of which the cooling bath (dry ice/acetone) was allowed to come gradually to RT. Subsequently, water was added gradually to the mixture, which was extracted twice with ethyl acetate. The combined organic phases were washed once with saturated aqueous sodium chloride solution, dried over sodium sulfate, filtered and concentrated, and the residue was purified by flash column chromatography (340 g silica gel Biotage Snap-Cartridge KP-Sil, cyclohexane/ethyl acetate gradient 93:7?3:7, Isolera One). The combined target fractions were concentrated and the residue was dried under reduced pressure. This gave 14.8 g (93% purity, 78% of theory) of the title compound. [0592] LC-MS (Method 1): Rt=2.22 min; MS (ESIpos): m/z=298 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-5-fluorophenylacetonitrile, its application will become more common.

Reference:
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengeseiisehaft; BECK, Hartmut; KAST, Raimund; MEININGHAUS, Mark; DIETZ, Lisa; FUERSTNER, Chantal; STELLFELD, Timo; ANLAUF, Sonja; VON BUEHLER, Clemens-Jeremias; BAIRLEIN, Michaela; ANLAHR, Johanna; MUENSTER, Uwe; TERJUNG, Carsten; JOERISSEN, Hannah; HAUFF, Peter; MUELLER, Joerg; DROEBNER, Karoline; NAGEL, Jens; (220 pag.)US2020/31775; (2020); A1;,
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Simple exploration of 2-Chloro-5-fluorophenylacetonitrile

According to the analysis of related databases, 395675-23-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 395675-23-7, name is 2-Chloro-5-fluorophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 395675-23-7

In step 1 Manufactured 2-(2-Chloro-5-fluorophenyl)acetonitrile (5.000 g, 29.485 mmol) and sodium hydride (60.00%, 2.948 g, 73.712 mmol) in N,N-dimethylformamide (40 mL) at 0 C and stirred for 30 min, to this mixture 1,3-dibromopropane (3.006 mL, 29.485 mmol) was added and this mixture was further stirred at room temperature for 18 hours. The reaction mixture was poured into water and extracted with dichloromethane. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. The concentrate was purified by column chromatography (SiO2, 80 g cartridge; ethyl acetate / hexane = 0% to 30%) and concentrated to give the title compound (2.271 g, 36.7%) as a white solid.

According to the analysis of related databases, 395675-23-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sources of common compounds: C8H5ClFN

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-fluorophenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 395675-23-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 395675-23-7, name is 2-Chloro-5-fluorophenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-(2-Chloro-5-fluorophenyl)-tetrahydropyran-4-carbonitrile 6.76 g of (2-chloro-5-fluorophenyl)-acetonitrile and 5.7 ml of 2,2-dichlorodiethyl ether are dissolved in 100 ml of dimethylformamide and mixed within 2.5 hours with 3.7 g of sodium hydride (60%) while being cooled with ice. After 3 hours at 0 C. and 16 hours at room temperature, it is mixed with ice water and ethyl acetate, acidified with 1 M hydrochloric acid, and the ethyl acetate phase is washed with water, dried (Na2SO4) and concentrated by evaporation. After chromatography on silica gel, 6.2 g of 4-(2-chloro-5-fluorophenyl)-4-pyranylcarbonitrile, flash point 91-93 C., is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-fluorophenylacetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jaroch, Stefan; Lehmann, Manfred; Schmees, Norbert; Buchmann, Bernd; Rehwinkel, Harmur; Droescher, Peter; Skuballa, Werner; Krolikiewicz, Konrad; Hennekes, Hartwig; Schaecke, Heike; Schottelius, Arndr; US2002/77356; (2002); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts