Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39263-32-6, name is 2-Amino-5-bromobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 39263-32-6
Using a literature procedure described in the following literature reference which is herein incorporated by reference in its entirety for all purposes as if fully set forth herein, a dry round bottom flask was charged with 2-amino-5-bromo benzonitrile (1 equivalent) and zinc cyanide (2 equivalents), and DMF was added: J. Med. Chem. 2000,43, 4063. Nitrogen was bubbled through the solution for 5 minutes, and Pd [P (Ph) 3] 4 was added in one portion. The reaction mixture was stirred at 90 C overnight. After cooling to room temperature, saturated NAHC03 was added, and the mixture was extracted with EtOAc. The organic extracts were collected and dried (NA2SO4). Evaporation of the solvent under reduced pressure and purification by column chromatography on silicagel (2% methanol in methylene chloride) afforded the desired 4-aminobenzene-1, 3-DICARBONITRILE as a white solid. GC/MS M/Z : 143 (M+, 100%), Rt 14.7 minutes
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CHIRON CORPORATION; WO2004/18419; (2004); A2;,
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