Category: 39095-25-5

Synthetic Route of 39095-25-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39095-25-5, name is 2,5-Dimethylterephthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The 2,5-dimethylterephthalonitrile (1.560 g, 10.0 mmol) was precisely weighed with an analytical balance.Azobisisobutyronitrile (0.082 g, 0.5 mmol) and NBS (3.916 g, 22.0 mmol) were placed in a dry 250 mL single port round bottom flask.Then use a measuring cylinder to measure 100 mL of carbon tetrachloride and pour it into the flask.Put on the reflux condenser,Vacuum and protect with argonPlace the flask in an oil bath heated to 80C or more and stir vigorously.And using a flame gun to assist in the rapid reflux,After rapid reflux, the temperature of the reaction system was adjusted to 80 C. for 16 hours. After the reaction is completed,The reaction mixture was cooled to room temperature and filtered.After washing with CCl 4 (3×20 mL), the filtrate was concentrated under reduced pressure to a brown-red viscous oil.Add ethanol (20 mL) to dissolve it slightly by heating.Transfer to a beaker (100 mL) and wash the flask with ethanol (3 x 10 mL).Pour the lotion into the beakerAfter leaving at room temperature to a total volume of 10 mL or less, it was filtered to obtain a white powdery product.The crude product was subjected to silica gel column chromatography [eluent: v (n-hexane): v (ethyl acetate) = 12:1].White powder, yield 31.6% (0.98g),

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dimethylterephthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zunyi Normal College; Huang Chibao; Zeng Boping; Liu Qibin; Zhang Daohai; (15 pag.)CN105085340; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 39095-25-5,Some common heterocyclic compound, 39095-25-5, name is 2,5-Dimethylterephthalonitrile, molecular formula is C10H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In 100ml 4-neck reactor 2,5-dimethyl-terephthalonitrile 2.3g, Carbon tetrachloride 23ml, NBS 5.3g, AIBN 0.07g 1 hour reaction at charged 75C It was. After completion of the reaction, it was allowed to cool to room temperature. Wash the residue and the reaction solution was filtered with carbon tetrachloride It was. Crude product is obtained in the oil and the filtrate was concentrated. The addition of methanol and allowed to crystallize the crude product. Taken out crystals were filtered off, 1,4-dicyano-2,5-bis-bromo methyl benzene was obtained 0.57g. In 50ml 3-necked reactor 1,4-dicyano-2,5-bis bromomethylbenzene 0.55g, Triethyl phosphite 0.61g was stirred and heated to charged 100-110 . At this temperature the reaction was carried out for 2 hours. Was allowed to cool to room temperature, and purified on a silica gel column 2,5-dicyano-1,4-bis (diethyl phosphonyl methyl) benzene was obtained 0.45g. 50ml 3-necked reactor to 2,5-dicyano-1,4-bis (diethyl phosphonyl methyl) benzene 0.45g, DMF (dehydration) 15ml, 4 formylpyridine 0.28g They were charged. After nitrogen substitution, Potassium t- butoxide 0.35g It was changed to green-brown solution and dropping the 5mlDMF solution slowly. It was allowed to react for 3 hours at 60 . The reaction mixture was extracted with chloroform and released into the water. The reaction mixture was concentrated to give crude product. The crude product was purified on a silica gel column (toluene / acetone 1/1) and the resulting solid to yield 0.08g of intermediate 45 and purified construed methanol. A synthesis flow of this intermediate 45 below

The synthetic route of 39095-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RICOH COMPANY LIMITED; YAMADA CHEMICAL COMPANY LIMITED; HIRANO, SHIGENOBU; YASHIRO, TOHRU; MANABE, YOUSUKE; HAYASHI, SATOSHI; (35 pag.)JP5900813; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts