Category: 38487-86-4

Synthetic Route of 38487-86-4,Some common heterocyclic compound, 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Amino-4-chlorobenzonitrile(153 mg, 1 mmol), [Cp * IrCl2] 2 (8 mg, 0.01 mmol, 1 mol%),Butyraldehyde oxime (96 mg, 1.1 mmol), p-xylene (2.0 mL) were sequentially added to a 25 mL Schlenk reaction flask.After the mixture was reacted at 70 C for 12 hours, cooled to room temperature, and then added to a 25 mL Schlenk flaskBenzaldehyde (117 mg, 1.1 mmol) was added. The mixture was further reacted at 110 C for 4 hours and then cooled toThe solvent was removed under vacuum at room temperature. Then through several petroleum ether washing, filtration, drying to be pure goalCompound, yield: 91%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-4-chlorobenzonitrile, its application will become more common.

Reference:
Patent; Nanjing University of Science and Technology; Zhao Wei; Wang Rongzhou; Li Feng; (17 pag.)CN106478525; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

38487-86-4, Adding a certain compound to certain chemical reactions, such as: 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38487-86-4.

Weigh 0.763 g (5 mmol) of 2-amino-4-chlorobenzonitrile was placed in a polytetrafluoroethylene liner of a stainless steel reactor and3 mL of a diethanolamine aqueous solution having a concentration of 1.33 mol / L was added and stirred for 2 minutes , The carbon dioxide was heated and the temperature was raisedto 100 C, and the carbon dioxide pressure was adjusted to 1 MPa for the carboxylation reaction under stable conditions for 12 hours.Antiupon end, the reaction system was cooled to room temperature slowly released unreacted carbon dioxide, was added 10mL of deionized water and stirreddispersion product, resulting precipitate was filtered and washed with a small amount of distilled water, and then 15mL / wash three times with methyl tert-butyl ether Andthe product was dried at a temperature of 100 C to give the product 7-chloroquinazoline-2,4 (1H, 3H) -dione in a yield of 62%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-4-chlorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; East China Normal University; Wu Haihong; Sheng Zhizheng; Wu Peng; (5 pag.)CN106946800; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 38487-86-4

General procedure: Benzonitrile 1a (103 mg, 1.0 mmol) and WEPPA (2.0 mL) were added into a 10-mL closed tubewith a stir bar. Then the reaction was stirred in a closed vessel synthesis reactor at 150 C for 0.5 h.After cooling to ambient temperature, the resulting precipitate was collected by filtration, washed withice water, and further dried in a vacuum drying oven. The filtrate was evaporated under reducedpressure. The resultant residue was purified by silica gel column chromatography (eluent: petroleumether (35-60 C)/EtOAc = 2:1 to 0:1, v/v). Finally, these two parts were combined to produce the desiredbenzamide 2a with a 94% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 38487-86-4.

Reference:
Article; Sun, Yajun; Jin, Weiwei; Liu, Chenjiang; Molecules; vol. 24; 21; (2019);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts