Category: 38487-86-4

Related Products of 38487-86-4, These common heterocyclic compound, 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Chloro-2-(lH-tetrazol-5-yl)aniline: 2-Amino-4-chlorobenzonitrile (1000 mg, 6.6 mmol), sodium azide (555 mg, 8.5 mmol) and triethylamine hydrochloride (1175 mg, 8.5 mmol) were taken up in 15 mL of toluene. The suspension was heated to 100 0C overnight. After cooling, the reaction mixture was washed 3 times with 5 mL portions of water. The combined aqueous fractions were acidified with concentrated hydrochloric acid. The desired 5-Chloro-2-(lH-tetrazol-5-yl)aniline precipitated from aqueous solution and was isolated by filtration (1090 mg, 85% yield). 1H NMR (500 MHz, DMSO-d6) delta 7.73 (d, IH), 6.97 (d, IH), 6.74 (dd, IH); MS (electrospray) m/z 196 (M+H).

Statistics shows that 2-Amino-4-chlorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 38487-86-4.

Reference:
Patent; EXELIXIS, INC.; WO2007/44724; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Amino-4-chlorobenzonitrile

Cyclohexanone (36mL), 2-amino-4-chlorobenzonitrile (4.6g, 30mmol) and zinc chloride (4.1g, 30mmol) were mixed in a flask and the mixture was heated to 120C for 3h. Following cooling to room temperature and evaporation of the solvent, the residue was diluted with ethyl acetate (30mL) and the solid was collected by filtration. A 10% aqueous solution of NaOH (50mL) was added. After stirring for 2h, the mixture was filtered, and the filter cake was washed with water and extracted with methanol. The combined extracts were concentrated to afford the desired product (4.7g) in 67% yield. 1H NMR (400MHz, DMSO) delta 8.17 (d, J=9.0Hz, 1H), 7.62 (d, J=2.0Hz, 1H), 7.28 (s, 1H), 6.46 (s, 2H), 2.81 (d, J=5.5Hz, 2H), 2.52 (s, 2H), 1.80 (d, J=4.7Hz, 4H). LC/MS (ESI): m/z 233.2 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Sun, Yang; Chen, Jianwen; Chen, Xuemin; Huang, Ling; Li, Xingshu; Bioorganic and Medicinal Chemistry; vol. 21; 23; (2013); p. 7406 – 7417;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 38487-86-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 38487-86-4, name is 2-Amino-4-chlorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 2-Aminobezonitrile derivatives (1 mmol),substituted carbonyl compounds (1.5 mmol) and [Nbmd][OH] (1 mL) werestirred at room temperature. The progress of the reaction was monitored byTLC under UV light. After completion of the reaction the mixture was extractedwith ethyl acetate (3 x 10 mL) and washed with water (3 x 10 mL). Thecombined extract was dried over anhydrous Na2SO4. The filtrate wasconcentrated under reduced pressure. The product was purified by columnchromatography over silica gel using n-hexane/ethyl acetate (3:1 v/v) aseluent to get the purified product. The products were then characterized byESI-MS, 1H NMR, 13C NMR and 1F NMR spectra.

The synthetic route of 2-Amino-4-chlorobenzonitrile has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38487-86-4, name is 2-Amino-4-chlorobenzonitrile, A new synthetic method of this compound is introduced below., COA of Formula: C7H5ClN2

3-phenylpropiolic acid(185 mg, 1.27 mmol) was suspended in dichloromethane (1.9 ml), there to oxalyl chloride (0.114 ml, 1.33 mmol), and stirred for 2 hours at room temperature was added a DMF (1 drop). Thereto 2-amino-4-chlorobenzonitrile (194 mg, 1.27 mmol) and stirred overnight at room temperature added. After the reaction, water was added. Through a diatomaceous earth column (VARIAN Chem Elute 12198006), it was washed with chloroform. The solvent was distilled off and the residue was purified by silica gel column chromatography (SNAP 25 g, hexane / ethyl acetate) to give the title compound (268 mg, 75.2%) as a pale yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of C7H5ClN2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2. In an article, author is Gribanov, Pavel S.,once mentioned of 38487-86-4.

One-Pot Synthesis of 5-Amino-1,2,3-triazole Derivatives via Dipolar Azide-Nitrile Cycloaddition and Dimroth Rearrangement under Solvent-Free Conditions

An efficient one-pot methodology for the preparation of 5-amino-1,2,3-triazole derivatives based on the combination of dipolar azide-nitrile cycloaddition with Dimroth rearrangement under solvent-free conditions has been developed.

If you¡¯re interested in learning more about 38487-86-4. The above is the message from the blog manager. Computed Properties of C7H5ClN2.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2. In an article, author is Cai, Yuan,once mentioned of 38487-86-4, Computed Properties of C7H5ClN2.

Fast Enantio- and Chemoselective Arylation of Ketones with Organoboronic Esters Enabled by Nickel/N-Heterocyclic Carbene Catalysis

A general, efficient, highly enantio- and chemoselective N-heterocyclic carbene (NHC)/Ni-catalyzed addition of readily available and stable arylboronic esters to ketones is reported. This protocol provides unexpectedly fast access (usually 10 min) to various chiral tertiary alcohols with exceptionally broad substrate scope and excellent functional group tolerance (76 examples, up to 98 % ee). This process is orthogonal to other known Ni-mediated Suzuki-Miyaura couplings, as it tolerates aryl chlorides, fluorides, ethers, esters, amides, nitriles, and alkyl chlorides. The reaction is applied to late-stage modifications of various densely functionalized medicinally relevant molecules. Preliminary mechanistic studies suggest that a rare enantioselective eta(2)-coordinating activation of ketone carbonyls is involved. This cross-coupling-like mechanism is expected to enable other challenging transformations of ketones.

Interested yet? Keep reading other articles of 38487-86-4, you can contact me at any time and look forward to more communication. Computed Properties of C7H5ClN2.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2. In an article, author is Kumar, Votarikari Naveen,once mentioned of 38487-86-4, HPLC of Formula: C7H5ClN2.

Effect of Surfactant on Swelling Behavior and Mechanical Characterization of NBR-Nano-Silica Nanocomposites

Acrylonitrile-based rubbers have gained much importance in the oil and gas industry due to their higher reliability and better oil-resistant property. The Present investigation deal with the addition of nano silica-based Nitrile Butadiene Rubber (NBR) has an influence on swelling and mechanical properties. The marginal increases of values were observed with the addition of nano-silica composite prepared through a two-step method with and without surfactant. Surfactant has increased the bridging between the NBR chains and nano-silica chains. The Swelling property of composite has increased with the addition of silica content, which implies that the base property of oil-resistant behavior has not diminished. The density and hardness values also reveal that the addition of nano-silica content has made the polymer brittle and toughened. The movement of polymeric chains was obstructing by the nano-silica content as it is hard and brittle. The temperature of oils also varied and found out the behavior of the composite was explained. The major challenge of obtaining the desired properties lies in the preparation method for the achievable dispersion of samples. The composite preparation method was adopted a two-step process, which was coagulated and entrapped the silica content into the polymeric chains. The presence of silica content is obstructing rheological movement, which is strengthened by the results of elastomeric graphs. Tensile, Tear, and shore hardness values were conducted to support the behavior of composite.

If you are hungry for even more, make sure to check my other article about 38487-86-4, HPLC of Formula: C7H5ClN2.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2. In an article, author is Jang, Seokhoon,once mentioned of 38487-86-4, Product Details of 38487-86-4.

n-Type host materials based on nitrile and triazine substituted tricyclic aromatic compounds for high-performance blue thermally activated delayed fluorescence devices

Novel n-type host materials based on tricyclic aromatic compounds, dibenzo [b,d] furan and dibenzo[b,d]thiophene (2Trz6CNDBF and 2Trz6CNDBT), have been successfully synthesized and characterized for highperformance blue thermally activated delayed fluorescence (TADF) organic light-emitting devices (OLEDs). Dibenzo[b,d]furan and dibenzo[b,d]thiophene were utilized as central molecular building blocks to achieve excellent thermal stability and high triplet energy (E-T). Nitrile and diphenyltriazine functional groups were introduced at the 6- and 2- positions of the central building blocks to achieve low-lying lowest unoccupied molecular orbital (LUMO) energy levels, high E-T, and excellent electron transport properties. UV-Vis absorption, low-temperature photoluminescence, and ultraviolet photoelectron spectroscopy analysis showed that 2Trz6CNDBF and 2Trz6CNDBT possessed high E-T (2.95 and 2.88 eV) and low-lying LUMO energy levels (-3.43 and -3.16 eV) that were well-matched with a blue TADF emitter, 5CzCN. Moreover, the electron-only device (EOD) result revealed that 2Trz6CNDBF and 2Trz6CNDBT had excellent electron transport properties. Blue TADF OLEDs fabricated with a p-type host material, mCBP, and n-type host, 2Trz6CNDBF or 2Trz6CNDBT, exhibited lower driving voltages (3.34 and 3.26 V, respectively) than a TADF OLED with only a p-type host material, mCBP (3.83 V). Blue TADF OLEDs with 2Trz6CNDBF and 2Trz6CNDBT exhibited superior external quantum efficiency (eta(ext), 15.6 and 14.7%), current efficiency (eta(ce), 33.8 and 32.7 cd A(-1)), and power efficiency (eta(pe) , 25.6 and 25.7 lm W-1), respectively. The eta(ext) and eta(ce )of blue TADF OLEDs with 2Trz6CNDBF and 2Trz6CNDBT increased by more than 70% and eta(pe) by approximately 150% compared to those of the TADF OLED with a single p-type host, mCBP. In addition, the device lifetimes of blue TADF OLEDs with 2Trz6CNDBF and 2Trz6CNDBT increased by more than 1000%. The efficient electron injection by the low-lying LUMO energy level, effective exciton confinement by high E-T, and high thermal stability of the film morphology provided the enhanced efficiency and lifetime for blue TADF OLEDs with 2Trz6CNDBF and 2Trz6CNDBT.

Interested yet? Keep reading other articles of 38487-86-4, you can contact me at any time and look forward to more communication. Product Details of 38487-86-4.

In an article, author is Sutanto, Fandi, once mentioned the application of 38487-86-4, COA of Formula: C7H5ClN2, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2, molecular weight is 152.581, MDL number is MFCD00035927, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.

Multicomponent reaction-derived covalent inhibitor space

The area of covalent inhibitors is gaining momentum due to recently introduced clinical drugs, but libraries of these compounds are scarce. Multicomponent reaction (MCR) chemistry is well known for its easy access to a very large and diverse chemical space. Here, we show that MCRs are highly suitable to generate libraries of electrophiles based on different scaffolds and three-dimensional shapes and highly compatible with multiple functional groups. According to the building block principle of MCR, acrylamide, acrylic acid ester, sulfurylfluoride, chloroacetic acid amide, nitrile, and alpha,beta-unsaturated sulfonamide warheads can be easily incorporated into many different scaffolds. We show examples of each electrophile on 10 different scaffolds on a preparative scale as well as in a high-throughput synthesis mode on a nanoscale to produce libraries of potential covalent binders in a resource-and time-saving manner. Our operational procedure is simple, mild, and step economical to facilitate future covalent library synthesis.

If you are interested in 38487-86-4, you can contact me at any time and look forward to more communication. COA of Formula: C7H5ClN2.

In an article, author is Hebert, Mathieu, once mentioned the application of 38487-86-4, Recommanded Product: 38487-86-4, Name is 2-Amino-4-chlorobenzonitrile, molecular formula is C7H5ClN2, molecular weight is 152.581, MDL number is MFCD00035927, category is nitriles-buliding-blocks. Now introduce a scientific discovery about this category.

Selective and eco-friendly recovery of glucosinolates from mustard seeds (Brassica juncea) using process optimization and innovative pretreatment (high voltage electrical discharges)

Glucosinolates (B-thioglucoside-N-hydroxysulfates) are rich-sulfur secondary metabolites presented in a large variety of plants mainly in Cruciferous. They may be hydrolyzed by an endogene enzyme called myrosinase to liberate numerous sub-products such as isothiocyanates, thiocyanates and nitriles. Glucosinolates possess biological activity, which reinforce their potential applications as natural biofumigant agents to replace chemical pes-ticides. However, the presence of these compounds in the meal after oil extraction blocks its use as animal feed. The objective of this investigation was to develop an eco-friendly process to recover glucosinolates from mustard seed meal rich in sinigrin and gluconapin conventionally extracted using methanol at high temperature. The object is to obtain simultaneously an active extract rich in GSL as biopesticide and a detoxified meal rich in proteins suitable for animal feeding. For this purpose, mustard seeds were first defatted using a laboratory hydraulic press. The pressing was occurred at 100 bars and 80 degrees C for 80 min allowing the recovery of 84% of intracellular oil. The obtained defatted meal is rich in proteins (35.8-40.8%), sinigrin (128.8-139.5 mu mol/g DM) and gluconapin (14.8-18.4 mu mol/g DM). The objective was to maximize the extraction of glucosinolates and to minimize the extraction of proteins using only green solvents (ethanol and water) to preserve the nutritional quality of meal as animal feed. Preliminar optimization was performed using grinding as standard pretreatment and followed by liquid/solid extraction; it allowed to recover 88% of sinigrin and 73.7% of gluconapin after 8 min using a solution of 40% ethanol at 40 degrees C in 10-fold excess (w/w). Only 19.6% and 20.3% respectively of sinigrin and gluconapin were recovered with the same conditions on untreated meal. Influence of high-voltage electrical discharges (HVED) on the selective extraction of glucosinolates was then investigated. The application of HVED at 40 kV for 5 ms permitted to recover 97% of sinigrin and 75% of gluconapin without further diffusion operation. Temperature increase during HVED operation did not exceed 12 degrees C. Glucosinolates extraction selectivity was better with HVED in compare to grinding + diffusion operation with lower proteins extraction (2.3% vs. 6.8%). The residual meal conserved high proteins content (40.3%) and very low glucosinolates concentration (6.8 mu mol/g DM), thus suitable for animal feeding. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

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