Category: 3759-28-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 2-(Cyanomethyl)benzonitrile

To a solution of 2-cyanophenylacetonitrile 26 (300mg, 2.11mmol) and 1, 3, 5-triazine (205.3mg, 2.53mmol) in MeOH (10.6mL) was added 28% NaOMe methanol solution (2.04g, 10.6mmol). The mixture was stirred at ambient temperature for 1h. The reaction mixture was poured into with 10% NH4Cl solution and MeOH. After removing the solvent, EtOAc and H2O was added. After separating EtOAc, the aqueous phase was extracted with EtOAc twice. The combined organics were dried over MgSO4, filtered, and concentrated in vacuo. The crude product was stirred in iPrOH/Heptane. The solid was collected after filtration to give the known amino-isoquinoline 27 (319.1mg, 81.6%) as pale yellow solid. The product was identified with previously reported data.

The synthetic route of 3759-28-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hayashida, Joji; Yoshida, Shinya; Tetrahedron Letters; vol. 59; 43; (2018); p. 3876 – 3879;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3759-28-2, name is 2-(Cyanomethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3759-28-2, name: 2-(Cyanomethyl)benzonitrile

General procedure: A mixture of 1-aryl/alkyl-3,3-bis-methylsulfanyl-propenone (1.0 mmol), 2-cyanomethyl-benzonitrile (1 mmol, 142.0 mg), and powdered KOH (2 mmol, 112.0 mg) in dry DMSO (5 mL) was stirred at room temperature for 2 h. Completion of reaction was monitored by TLC. After completion, reaction mixture was poured onto ice-water with constant stirring and then neutralized with 10% HCl. The precipitate obtained was filtered, washed with water and dried over dry sodium sulfate. Many compounds were purified by recrystallization in dry methanol. Some compounds were purified through column chromatography using 15% ethylacetate in hexane as an eluent. Characterization data for some of the synthesized compounds are reported earlier.17

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Cyanomethyl)benzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Singh, Surjeet; Althagafi, Ismail; Yadav, Pratik; Panwar, Rahul; Kumar, Abhinav; Pratap, Ramendra; Tetrahedron; vol. 70; 46; (2014); p. 8879 – 8884;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts