Category: 3695-84-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3695-84-9, name is Methyl 2-cyano-3-phenylacrylate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C11H9NO2

General procedure: A mixture of pyrazoline-5-one 1 (5 mmol), activated olefin 2 (5 mmol) and sodium bromide (0.31 g, 3 mmol) in methanol (20 mL) was electrolyzed in undivided cellequipped with a magnetic stirrer, a graphite anode and an iron cathode at 20 C under a constant current density of 100 mA cm-2 (I = 500 mA, electrodes square5 cm2) until the quantity of electricity 2.5 Fmol-1 of charge was passed. After the electrolysis was finished, spirocyclopropylpyrazolone 3 was filtered out and dried under reduced pressure. An additional amount of spirocyclopropylpyrazolone was isolated as follows. The reaction mixture was concentrated to 5 mL and cooled to -10 C overnight and filtered.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3695-84-9.

Reference:
Article; Elinson, Michail N.; Dorofeeva, Evgeniya O.; Vereshchagin, Anatoly N.; Korshunov, Alexander D.; Egorov, Mikhail P.; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2191 – 2200;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3695-84-9, name is Methyl 2-cyano-3-phenylacrylate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3695-84-9, Quality Control of Methyl 2-cyano-3-phenylacrylate

General procedure: To a mixture of alkene 1 (0.5 mmol), aldehyde 2 (2.5 mmol), and FeCl2 (1.6 mg, 0.0125 mmol), acetonitrile (3.0 mL) was added under nitrogen at room temperature. Then tert-butyl hydroperoxide 3 (TBHP, 2.0 mmol, 5-6 M in decane) was dropped into the mixture under nitrogen at room temperature. The resulting mixture was stirred under 85 oC for 1 h. The temperature of reaction was cooled to room temperature. The resulting reaction solution was directly filtered through a pad of silica by ethyl acetate. The solvent was evaporated in vacuo to give the crude products. NMR yields are determined by 1H NMR using dibromomethane as an internal standard. Solvent was evaporated and the residue was purified by flash column chromatography on silica gel with ethyl acetate/petroleum ether as eluent to afford the pure product 4.

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Reference:
Article; Liu, Kaisheng; Li, Yuanming; Zheng, Xiaojian; Liu, Weiping; Li, Zhiping; Tetrahedron; vol. 68; 50; (2012); p. 10333 – 10337;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts