Category: 3672-47-7

Synthetic Route of 3672-47-7,Some common heterocyclic compound, 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, molecular formula is C10H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Ketonitrile 5 (100 mmol) was added to 15% aqueous NaOH solution(100 mL) followed by hydroxylamine (200 mmol). The resulting mixture was heated at reflux for 14 h, cooled down to r.t., theresulting precipitate was isolated by filtration and crystallized from isopropyl alcohol.

The synthetic route of 3672-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Krasavin, Mikhail; Korsakov, Mikhail; Zvonaryova, Zhanna; Semyonychev, Evgenii; Tuccinardi, Tiziano; Kalinin, Stanislav; Tanc, Muhammet; Supuran, Claudiu T.; Bioorganic and Medicinal Chemistry; vol. 25; 6; (2017); p. 1914 – 1925;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3672-47-7, Application In Synthesis of 3-(4-Methoxyphenyl)-3-oxopropanenitrile

2. Synthesis of Intermediate 2:Sodium hydroxide (1.76 g, 44 mmol)Was dissolved in 140 mL of 80% aqueous ethanol,1 (7 g, 40 mmol) was added to the reaction flask,N, N-diethylchloroacetamide (5.98 g, 40 mmol),Sodium iodide (14.99 g, 100 mmol).Room temperature reaction for 12 hours.The solvent was distilled off under reduced pressure,To the residue was added 100 mL of saturated brine and 200 mL of ethyl acetate,After thorough mixing,Separate the organic layer,Dried over anhydrous sodium sulfate,Concentrated, column chromatography,To give product 2 (7.72 g, 67%) as a red oil.

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Reference:
Patent; Xiamen University Affiliated Zhongshan Hospital; Su Xinhui; Wang Liangliang; Li Yesen; Guo Zhide; Zhang Xianzhong; Chen Lichun; (18 pag.)CN106749279; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 3672-47-7, A common heterocyclic compound, 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Fresh cells and lyophilised cells of Rhodotorula rubra MIM147 were used 20gL-1 dry weight re-suspended in phosphate buffer or in tap water with 50gL-1 of glucose; then the substrates 1, 3-10 were dissolved in DMSO and added at 2gL-1 concentration. For substrate 1, biotransformations were also carried out at 4, 6 or 10gL-1 concentration.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Rimoldi, Isabella; Facchetti, Giorgio; Nava, Donatella; Contente, Martina Letizia; Gandolfi, Raffella; Tetrahedron Asymmetry; vol. 27; 9-10; (2016); p. 389 – 396;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3672-47-7, SDS of cas: 3672-47-7

3-(4-methoxyphenyl)-3-oxopropanenitrile (2) (2.8571 mmol, 1 equiv.) and hydroxylamine hydrochloride (H2NOH.HCI) (2.8856 mmol, 1.05 equiv.) were added to solution of sodium hydroxide (NaOH) (5.8570 mmol, 2.05 equiv.) in water. The reaction mixture was refluxed for 4 h. After the resulting mixture cooled down to RT, it was diluted with water and extracted with dichloromethane (DCM). The organic layer was dried, filtered and evaporated to give the crude product, which was purified by automated -flash chromatography on silica gel (24 g) eluting with a gradient of 0-60% ethyl acetate (EtOAc) in hexane. Yield 59%. MP: 135.4-137.2C. HRMS (m/z): [M+H]+ calculated for C H N O : 191.0821; found: 191.0812

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methoxyphenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BANO?LU, Erden; CALI?KAN, Burcu; ?AH?N, Oezguer; LENGERL?, Deniz; AKBULUT, Oezge; (39 pag.)WO2020/18039; (2020); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 3672-47-7, The chemical industry reduces the impact on the environment during synthesis 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, I believe this compound will play a more active role in future production and life.

To a stirred solution of 0.30 g (1.71 mmol) 3-(4-methoxy-phenyl)- 3-oxo-propionitrile in 10 ml ethanol was added 0.17 ml (1.71 mmol) cyclohexanone, 53 mg (1.71 mmol) sulfur, EPO and 0.14 ml (1.71 mmol) morpholine. The mixture was heated at 40 0C for the week end, and then poured onto water and extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. Trituration in ether afforded 0.51 g (85%) (2-amino-4,5,6,7-tetrahydro-benzo[b]thiophen-3-yl)-(4- methoxy-phenyl)-methanone as an orange solid. ES-MS m/e (%): 288 (M+H+, 100).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methoxyphenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F.HOFFMANN-LA ROCHE AG; WO2006/63732; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 3672-47-7, A common heterocyclic compound, 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The enzymatic reaction was performed biotransformations at 25mL-scale, using an enzyme-coupled system (glucose and glucose dehydrogenase from Bacillus megaterium) for cofactor recycling. Biotransformations were carried out by addition of 10mM substrate dissolved in 250muL of DMSO, 0.1mM NADP+, KRED1-Pglu (20mU/mL), GDH (1U/mL), glucose 40mM in Tris/HCl buffer pH 8.0 (0.05M, 25mL) at 30C. Biotransformations of 1k-n were also performed also in acetate buffer (NaAB 0.1M, pH 5.0). The reaction mixture was kept under stirring at 30C until completion and then extracted with 20mL of EtOAc; the aqueous phase was extracted twice more with 15mL of EtOAc. The organic phases were collected and dried over Na2SO4 and the solvent was evaporated. The crude residue was purified by flash chromatography.

The synthetic route of 3672-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Contente, Martina L.; Serra, Immacolata; Molinari, Francesco; Gandolfi, Raffaella; Pinto, Andrea; Romano, Diego; Tetrahedron; vol. 72; 27-28; (2016); p. 3974 – 3979;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts