Category: 35704-19-9

Synthetic Route of 35704-19-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35704-19-9, name is N-(4-Cyanophenyl)acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The R-N02 or R-CN (1 mmol), G-NiPd catalyst (4mg), and water:methanol (3:7) were stirred 5 mm in a 100 mL thermolysis tube at room temperature. Next, AS (3 mmol) was added to the reaction mixture and the vessel was closed. Reaction was then continued under vigorous stirring at room temperature. The progress of the catalytic reaction was monitored by thin layered chromatography (TLC). Most reactions completed over the time period of 5-30 mi Afier completion of the reaction, the catalysts were removed by centrifugation at 7000 rpm and washed three times with water or methanol. Then, the catalysts were allowed to dry for further uses. The solvent was removed by using a rotary evaporatot Finally, the crude residue was directly purified by colunm chromatography on silica gel using acetone. The yields of the reduced compounds were determined by ?H and ?3C NMR with D20, DM50, CD3OD or CDC13 as the solvent depending on the product separated.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(4-Cyanophenyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BROWN UNIVERSITY; Sun, Shouheng; Ho, Sally Fae; Mendoza-Garcia, Adriana; (10 pag.)US2016/279619; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 35704-19-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35704-19-9, name is N-(4-Cyanophenyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows.

In a 50-mL round bottom ask equipped with a magnetic stirrer and an oil-bath, a mixture of p-cyanoacetanilide (2.93 g, 18.3 mmol), sodium azide (2.37 g, 36.5 mmol), and ammonium chloride (0.53 g) as a catalyst was dissolved in 20 mL of DMF and reuxed for 12 h. The reaction progression was controlled by thin layer chromatography (TLC) with the solvent mixture of EtOAc:cyclohexane:methanol/8:10:2 (V/V). The reactioncolor turned pale yellow and the solvent was removed under reduced pressure by a rotary evaporator. The viscous residue was put on an ice-bath, hydrochloric acid (2 M) was added dropwise until the pH was 1, and the white solid was precipitated, filtered out, and recrystallized with the mixture of methanol and water (3.1 g,84% yield). Colorless solid, mp 289{300 C; FT IR (KBr) 3311, 3267 (NHCO), 3195, 3129, 3069, 2985, 2920, 2854,2706, 2615, 2471 (N4 H, CH-ar.), 1678 (C=O) cm1 ; 1H NMR (400 MHz, DMSO-d6) 2.09 (s, 3H, CH3) ,3.44 (bs, 1H), 7.78 (d, 2H, J = 8.3 Hz, CH-ar.), 7.96 (d, 2H, J = 8.3 Hz, CH-ar.), 10.26 (s, 1H, NHCO); 13CNMR (100 MHz, DMSO-d6) : 24.2 (CH3) , 118.4 (C-ar.), 119.2 (CH-ar.), 127.7 (CH-ar.), 141.9 (C-ar.), 155.0(C-tetrazole), 168.9 (C=O).

The chemical industry reduces the impact on the environment during synthesis N-(4-Cyanophenyl)acetamide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Pesyan, Nader Noroozi; Soleimani, Davoud; Jazani, Nima Hosseini; Turkish Journal of Chemistry; vol. 39; 5; (2015); p. 998 – 1011;,
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Synthetic Route of 35704-19-9, These common heterocyclic compound, 35704-19-9, name is N-(4-Cyanophenyl)acetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B. 3-nitro-4-acetamidobenzonitrile Sixty-seven grams of potassium nitrate were gradually stirred into 300 ml. of concentrated sulfuric acid at 9 C. to form a paste. Fifty grams of 4-acetamidobenzonitrile were added portionwise to the cold acid mixture. The reaction mixture was maintained at -5 C. for about 1 hour. The thick mixture was poured onto cracked ice. The product was collected and washed with cold water. The wet solid was added portionwise to about 400 ml. of warm acetic anhydride very carefully. Water was added to destroy the excess anhydride. The nitro product was collected and recrystallized from ethanol to yield 25.5 g. of 3-nitro-4-acetamidobenzonitrile m.p. 127-129 C. A second crop, 23 g., was obtained.

Statistics shows that N-(4-Cyanophenyl)acetamide is playing an increasingly important role. we look forward to future research findings about 35704-19-9.

Reference:
Patent; Eli Lilly and Company; US4018790; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35704-19-9, name is N-(4-Cyanophenyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H8N2O

General procedure: In a double-necked round bottom flask (100 mL) equippedwith a condenser was added a mixture consisting ofnitrile (0.005 mol), NaN3 (0.006 mol), and monodisperse Pt NPsVC in DMF (1.5 mL). The mixture washeated at reflux until TLC monitoring indicated no furtherimprovement in the conversion. The reaction mixture wasthen cooled to room temperature, vacuum-filtered usinga sintered-glass funnel and the residue was washed withethyl acetate (3×10 mL). The filtrate was treated with5 mL HCl (4 mol L-1 to reach pH= 3 and it was allowedto stir for 30 minutes. Subsequently, the organic layer wasseparated, dried over anhydrous Na2SO4 and evaporated.The crude product was purified by recrystallization and/orcolumn chromatography on silica gel eluted with propersolvents to get pure 5-Phenyl 1H-tetrazole.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35704-19-9.

Reference:
Article; Baskaya, Gaye; Esirden, Ibrahim; Erken, Esma; Sen, Fatih; Kaya, Muharrem; Journal of Nanoscience and Nanotechnology; vol. 17; 3; (2017); p. 1992 – 1999;,
Nitrile – Wikipedia,
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35704-19-9, name is N-(4-Cyanophenyl)acetamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

General procedure: A mixture of 1a (34 mg, 0.250 mmol), 2a (149 mg, 0.500 mmol) and TBAT (540 mg, 1.00 mmol) in toluene (3 mL) was stirred at 50 C for 18 h. After this time, the reaction mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue obtained was purified by flash chromatography (silica, heptane to 2:3 ethyl acetate/heptane) to afford 3a (45 mg, 85%) as an off-white solid.

The synthetic route of 35704-19-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 35704-19-9, name is N-(4-Cyanophenyl)acetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35704-19-9, name: N-(4-Cyanophenyl)acetamide

STR105 To a solution of 4-acetamidobenzonitrile (9.40 g) in concentrated sulfuric acid (80 ml) was added potassium nitrate in small portions at a temperature not exceeding 10 C. The reaction mixture was stirred at 5-10 C. for 2 hours and poured into ice-water and the separated crystals were collected by suction. To the crystals was added 4N hydrochloric acid (100 ml) and the mixture was refluxed for 2 hours. After cooling to room temperature, the crystals were recovered by filtration, washed with water and dried under reduced pressure to give 7.22 g of 4-amino-3-nitrobenzonitrile. Mass spectrum (m/z): 163 (M+). NMR (DMSO-d6) delta: 7.00-7.14 (1H, m), 7.60-8.10 (3H, m), 8.40-8.60 (1H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(4-Cyanophenyl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US5162318; (1992); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

35704-19-9, Adding a certain compound to certain chemical reactions, such as: 35704-19-9, name is N-(4-Cyanophenyl)acetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35704-19-9.

PREPARATION 9 An aqueous solution (200 ml) of calcium hypochlorite (21 g) was added to a solution of p-cyanoacetanilide (12.5 g) in ethanol (27 ml), acetic acid (27 ml), and water (27 ml). The mixture was stirred for 4 days and extracted with chloroform. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, and concentrated to give a powder of 2′-chloro-4′-cyanoacetanilide (12.5 g).

According to the analysis of related databases, 35704-19-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4866091; (1989); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts