Related Products of 35525-86-1, These common heterocyclic compound, 35525-86-1, name is 4-((Dimethylamino)methyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The reported procedure was applied with modification [42]. A solution of 4-(aminomethyl)benzonitrile (7), dissolved in tetrahydrofuran was added dropwise under a nitrogen atmosphere to a stirred suspension of LiAlH4 (4 eq) in tetrahydrofuran. The reaction mixture was stirred overnight at room temperature. The reaction was quenched by minimum amount of aqueous saturated sodium sulfate solution under a chilling temperature. The slurry mixture was filtered under vacuo and the residue washed with ethyl acetate. The combined filtrates dried over sodium sulfate, and evaporated in vacuo to afford oil or white solid products in 41-82% yields.
The synthetic route of 35525-86-1 has been constantly updated, and we look forward to future research findings.