Category: 3544-25-0

Adding a certain compound to certain chemical reactions, such as: 3544-25-0, name is 2-(4-Aminophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3544-25-0, Computed Properties of C8H8N2

General procedure: Propionyl chloride (6.0mmol) in dry CH2Cl2 (10mL) was added dropwise to a mixture of 4-methoxybenzenamine (5.0mmol), sodium bicarbonate (12.5mmol) and dry CH2Cl2 (15mL). The mixture was stirred in ice water bath for 1h and poured into water and then extracted with CH2Cl2 (3¡Á30mL). The combined organic layer was washed with brine and dried over anhydrous MgSO4. The solvent was evaporated to dryness to afford the compound 4a. Others amide derivatives 4b-4s were synthesized similarly. Physical constants and spectral data of compounds 4a-4s are summarized below.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(4-Aminophenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Article; Ji, Qinggang; Yang, Dan; Wang, Xin; Chen, Chunyan; Deng, Qiao; Ge, Zhiqiang; Yuan, Lvjiang; Yang, Xiaolan; Liao, Fei; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3405 – 3413;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3544-25-0, name is 2-(4-Aminophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H8N2

Take carbazole monoaldehyde 0.502g (2mmol)Add about 3 mL of dichloromethane to a 100 mL round bottom flask to dissolve completely.Then, 0.3 g of p-aminophenylacetonitrile and 30 mL of ethanol were added to the flask.1.5 mL of TBAH (tetrabutylammonium hydroxide) was added dropwise as a catalyst.The progress of the reaction was monitored by thin layer chromatography and reacted at 80 C for 12 hours.The reaction mixture was cooled and a small amount of yellow precipitate was precipitated.Dry the organic phase to a yellow solid, dissolve it with a small amount of dichloromethane and pour it into a beaker.Add 100mL of ethanol and stir. A large amount of yellow solid precipitates and is quickly filtered.The solid obtained by suction filtration was washed three times with ethanol.The collected solid was dried and weighed 0.44 g of an orange-red solid with a yield of about 60%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3544-25-0.

Reference:
Patent; Anhui University; Zhu Weiju; Fang Min; Liu Xiaonan; Ge Jialong; Li Cun; Wu Zhenyu; (12 pag.)CN108640867; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts