34662-29-8 Archives - Page 6 of 6 - Nitriles-buliding-blocks

Bec, Anja et al. published their research in Pharmaceuticals in 2021 |CAS: 34662-29-8

The Article related to phenylacrylonitrile benzimidazole preparation diastereoselective antitumor sar apoptosis mol docking, acrylonitriles, antiproliferative activity, benzimidazoles, docking analysis, molecular dynamics simulations, tubulin polymerization and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Bec, Anja; Hok, Lucija; Persoons, Leentje; Vanstreels, Els; Daelemans, Dirk; Vianello, Robert; Hranjec, Marijana published an article in 2021, the title of the article was Synthesis, Computational Analysis, and Antiproliferative Activity of Novel Benzimidazole Acrylonitriles as Tubulin Polymerization Inhibitors: Part 2.Reference of 3-Chloro-4-nitrobenzonitrile And the article contains the following content:

Classical linear and microwave-assisted synthesis methods was used to prepare novel N-substituted, benzimidazole-derived acrylonitriles I [R1 = H, cyano; R2 = Me, iso-Bu, Ph, etc.; R3 = H, 2-methoxy, 3,4,5-trimethoxy, etc.] with antiproliferative activity against several cancer cells in vitro. The most potent systems showed pronounced activity against all tested hematol. cancer cell lines, with favorable selectivity towards normal cells. The selection of lead compounds was also tested in vitro for tubulin polymerization inhibition as a possible mechanism of biol. action. A combination of docking and mol. dynamics simulations confirmed the suitability of the employed organic skeleton for the design of antitumor drugs and demonstrated that their biol. activity relies on binding to the colchicine binding site in tubulin. In addition, it also underlined that higher tubulin affinities are linked with (i) bulkier alkyl and aryl moieties on the benzimidazole nitrogen and (ii) electron-donating substituents on the Ph group that allow deeper entrance into the hydrophobic pocket within the tubulin’s β-subunit, consisting of Leu255, Leu248, Met259, Ala354, and Ile378 residues. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Matsuo, Masaaki et al. published their patent in 1989 |CAS: 34662-29-8

The Article related to alkanesulfonanilide preparation analgesic antiinflammatory, sulfonanilide alkane preparation analgesic antiinflammatory, antirheumatic alkanesulfonanilide preparation, antipyretic alkanesulfonanilide preparation, antiarthritic alkanesulfonanilide preparation and other aspects.HPLC of Formula: 34662-29-8

On September 12, 1989, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of alkanesulfonanilide derivatives as analgesics and inflammation inhibitors. And the patent contained the following:

Title compounds I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxy; R3 = alkyl; R4 = acyl, cyano, HO2C, hydroxyalkyl, HS, alkylthio, alkylsulfinyl, alkylsulfonyl, Q, R7N:CR6, alkanoylalkenyl, (un)substituted 5-membered unsat. heterocyclyl, PhS; R6 = H, H2N, alkyl; R7 = OH, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, H2NCONH, H2NCSNH; R5 = H, halo, alkyl, alkanoyl] and pharmaceutically acceptable salts thereof were prepared I are also useful for treating pyretic diseases, rheumatism, and arthritis. 4′-Amino-3′-(2,4-difluorophenoxy)acetophenone (preparation given) and MeSO2Cl in pyridine were stirred overnight at room temperature to give I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-Ac; R8 = 4-F). Similarly prepared was I (R1 = R5 = H; R2 = 2-F; R3 = Me; R4 = 4-cyano; R8 = 4-F) (II). The analgesic activity was demonstrated with II showing an oral ED50 at 2.4 mg/kg in the HOAc-induced writhing test in mice (cf. 1.6 mg/kg for indomethacin). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deshmukh, Mahesh S. et al. published their research in RSC Advances in 2013 |CAS: 34662-29-8

The Article related to fluoro nitrobenzene diamine dual aromatic nucleophilic substitution, quinoxaline preparation, aminoalc fluoro nitrobenzene dual aromatic nucleophilic substitution, benzoxazine preparation, diol fluoro nitrobenzene dual aromatic nucleophilic substitution, benzodioxine preparation and other aspects.Recommanded Product: 34662-29-8

Deshmukh, Mahesh S.; Das, Biswajit; Jain, Nidhi published an article in 2013, the title of the article was Dual SNAr reaction in activated ortho-halonitrobenzene: direct synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines.Recommanded Product: 34662-29-8 And the article contains the following content:

An unprecedented one-pot synthesis of substituted 1,2,3,4-tetrahydroquinoxalines, 2,3-dihydro-1,4-benzoxazines and 1,4-benzodioxines from activated ortho-halonitrobenzenes was accomplished by dual nucleophilic aromatic substitution (SNAr) of halogen followed by substitution of the nitro group by secondary diamines, secondary amino alcs. and diols resp. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nakao, Akira et al. published their patent in 2011 |CAS: 34662-29-8

The Article related to bisglycinamide derivative preparation homocysteine synthase inhibitor, carbamoylmethylglycinamide preparation homocysteine synthase inhibitor, adenosyl homocysteine hydrolase inhibitor bisglycinamide derivative preparation, arteriosclerosis cerebral infarction myocardial infarction prevention treatment bisglycinamide preparation and other aspects.Computed Properties of 34662-29-8

On April 14, 2011, Nakao, Akira; Suzuki, Hiroko; Tatsumi, Ryo; Setsuta, Tomofumi; Seki, Maki; Iwasaki, Hiroshi; Zheng, Zhongli; Makara, Gergely; Dai, Chaoyang; Siddiqui, Arshad; Kawahata, Noriyuki; Nan, Yang published a patent.Computed Properties of 34662-29-8 The title of the patent was Preparation of bis(glycinamide) derivatives as homocysteine synthase inhibitors. And the patent contained the following:

There are disclosed homocysteine synthase inhibitors which are useful for the prevention or treatment of diseases associated with a homocysteine synthase, e.g. arteriosclerosis, cerebral infarction, or myocardial infarction. There are specifically disclosed N-(carbamoylmethyl)glycinamide compounds represented by general formula [I; R1 = H, C1-3 alkyl; R2 = (un)substituted heterocyclyl containing at least one N atom in the ring, NR2aR2b; R2a, R2b = H, C1-6 alkyl, haloalkyl, (un)substituted aryl; R3 = H; R4, R5, R6, R7 = H, C1-4 alkyl; L = [C(R8a)(R8b)]s[C(R8c)(R8d)]t; s, t = an integer of 0-2; R8a, R8b, R8c, R8d = H, C1-3 alkyl; Ar = l = an integer of 0-4; X = O, S; R9 = each (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, heterocyclyl, aryl, heteroaryl, or arylalkyl; R10 = halo, cyano, C1-6 alkyl, CF3, HO, C1-4 alkoxy, CF3O, COR12, each (un)substituted NH2, aryl, heteroaryl, heterocyclyl, C1-6 alkyl-S(O)m; R12 = HO, C1-6 alkyl, C1-6 alkoxy, (un)substituted NH2; m = an integer of 0-2; A = each (un)substituted aryl, aryl-C1-4 alkyl, heteroaryl-C1-4 alkyl, C3-6 alkynyl, or C3-8 cycloalkyl, Q1, Q2, etc.; n = an integer of 0-2; h = 0, 1; i = 1, 2; R14 = C1-4 alkyl, W = :CH, :N], pharmacol. acceptable salts of the compounds, or solvates of the compounds or the pharmacol. acceptable salts. Thus, N-[5-chloro-2-(4-chlorophenoxy)phenyl]-N-[2-[(1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl]glycine 412, tert-Bu (2-aminoethyl)methylcarbamate hydrochloride 270, and 1-hydroxybenzotriazole 181 mg were dissolved in 1 mL DMF and 10 mL CH2Cl2, treated with 265 mg 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and stirred at room temperature for 3 h to give, after workup and silica gel chromatog., 75% N’-[5-chloro-2-(4-chlorophenoxy)phenyl]-N’-[2-[(1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl]-N-[2-[(tert-butoxycarbonyl)(methyl)amino]ethyl]glycinamide (II) (407 mg). II (387 mg) was dissolved in 2 mL CH2Cl2, treated with 2.0 mL 4 N HCl/dioxane solution at room temperature, and stirred at room temperature for 90 min, and treated with Et2O for precipitation of a solid which was filtered off and dried under reduced pressure to give 64% N’-[5-chloro-2-(4-chlorophenoxy)phenyl]-N’-[2-[(1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl]-N-[2-(methylamino)ethyl]glycinamide (III) dihydrochloride. III.2HCl in vitro showed IC50 of 2.6 nM for inhibiting the hydrolysis of S-adenosyl-L-homocysteine by human recombinant S-adenosyl-L-homocysteine hydrolase. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Computed Properties of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Simple exploration of 34662-29-8

Statistics shows that 3-Chloro-4-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 34662-29-8.

Electric Literature of 34662-29-8, These common heterocyclic compound, 34662-29-8, name is 3-Chloro-4-nitrobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-chloro-4-nitrobenzonitrile (620 mg, 2.4 mmol, Chem. Pharm. Bull, (1992) 2399-2404), 1,1-carbonyldiimidazole (778 mg, 4.8 mmol) in tetrahydrofurane (30 ml) was stirred at room temperature overnight. To the mixture was added water (30 ml) and the whole was extracted with ethyl acetate (100 ml×2). The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=1/1 as eluent) to afford the titled compound as a white solid (415 mg, 65%). [0455] 1H-NMR (CDCl3) delta:10.96 (s, 1H), 7.17-7.30 (m, 2H), 7.05 (d, J=8.1 Hz, 1H), 6.89 (d, J=1.3 Hz, 1), 4.07 (t, J=7.0 Hz), 3.02 (t, J=7.0 Hz, 2H) ppm.

Statistics shows that 3-Chloro-4-nitrobenzonitrile is playing an increasingly important role. we look forward to future research findings about 34662-29-8.

Reference:
Patent; Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao; US2004/204409; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sources of common compounds: 3-Chloro-4-nitrobenzonitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-4-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 34662-29-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34662-29-8, name is 3-Chloro-4-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 3-chloro-4-nitrobenzonitrile (3 g, 16.4 mmol, Chem. Pharm. Bull., 1992, 2399-2404), 2-phenylethanamine (2.5 ml, 19.7 mmol) and potassium carbonate (3.4 g, 24.6 mmol) in ethanol (200 ml) was refluxed for 5 hr. To the mixture was added 2 N aqueous NaOH (100 ml) and the whole was extracted with ethyl acetate (100 ml¡Á2). The combined organic layers were washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=1/8 as eluent) to afford the titled compound as a yellow solid (936 mg, 21%). [0371] 1H-NMR (CDCl3) delta:8.49 (d, J=2.0 Hz, 1H), 8.43 (br.s, 1H), 7.57 (dd, J=2.2, 8.8 Hz, 1H), 7.24-7.39 (m, 5H), 6.89 (d, J=9.0 Hz, 1H), 3.58-3.65 (m, 2H), 3.04 (d, J=7.1 Hz, 2H) ppm.