Category: 34662-29-8

On June 8, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Name: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Name: 3-Chloro-4-nitrobenzonitrile

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On November 30, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo; Okumura, Hiroyuki published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of alkanesulfonanilides as analgesics and antiinflammatories. And the patent contained the following:

The title compounds [I; Ar = Q; R1 = alkyl, haloalkyl; R2 = acyl, cyano, CO2H, (un)substituted alkyl, etc.; R3 = H, NO2, alkyl, halo; R4-R7 = H, halo, haloalkyl, alkoxy, (un)substituted heterocyclyl; X = S(O)n, NHCO, CONH, R8N, R9CH; R8 = H, alkyl; R9 = H, OH; n = 0-2] and their pharmaceutically acceptable salts were prepared NaBH4 was added to 4′-acetyl-2′-[(2,4-difluorophenyl)thio]methanesulfonanilide in MeOH, and the mixture stirred overnight at room temperature and treated with AcOH to give 2′-[(2,4-difluorophenyl)thio]-4′-(1-hydroxyethyl)methanesulfonanilide (II). In rats 10 mg II/kg orally gave 90.1% inhibition of secondary lesions induced by Mycobacterium聽tuberculosis, a measure of antiinflammatory activity. 4′-Acetyl-2′-[(2,4-difluorophenyl)amino]methanesulfonanilide, also prepared, had an analgsic ED50 of 1.8 mg/kg orally in the mouse writhing test. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to alkanesulfonanilide preparation analgesic antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On January 25, 1990, Yoshikawa, Yoshinari; Ochi, Yutaka; Sekiuchi, Kazuto; Saito, Hideji; Hatayama, Katsuo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of sulfonanilide derivatives as antiinflammatory agents. And the patent contained the following:

Sulfonanilides [I; R1 = C1-4 alkyl; R2 = C1-4 alkyl, Ph, AR4 wherein R4 = Ph, halo-substituted Ph or cycloalkyl, A = O, S; R3 = halo, haloalkyl, Ph, CHO, alkoxycarbonyl, etc.] are prepared Reduction of 5.0 g nitro compound II (R = NO2) in EtOH over 5% Pd-C gave 4.4 g amine II (R = NH2), which (3.3 g) was diazotized and the diazonium salt treated with KCN to give 1.2 g cyano compound II (R = cyano) (III). III at 50 mg/kg p.o. showed 48.9% inhibition of carrageenan-induced edema in rats, vs. 41.6% inhibition with ibuprofen. Also prepared were 35 addnl. I. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8

The Article related to sulfonanilide preparation antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 34662-29-8

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Nitrile – Wikipedia,
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On December 1, 2021, Desai, Jigar; Patel, Bhaumin; Darji, Brijesh; Gite, Archana; Panchal, Nandini; Bhosale, Gokul; Shedage, Sandeep; Patel, Sandip; Kadam, Pravin; Patel, Gautam; Kumar Srivastava, Brijesh; Joharapurkar, Amit; Kshirsagar, Samadhan; Giri, Poonam; Bhayani, Hitesh; Patel, Ankit; Ghoshdastidar, Krishnarup; Bandyopadhyay, Debdutta; Kumar, Sanjay; Jain, Mukul; Sharma, Rajiv published an article.Quality Control of 3-Chloro-4-nitrobenzonitrile The title of the article was Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19). And the article contained the following:

Rationally designed trifluoromethylsulfonyl derivatives were identified as novel, potent and orally bioavailable B0AT1 (neutral amino acid transporter) inhibitors. The compound I was found to be nanomolar potent (IC50: 0.035渭M) B0AT1 inhibitor with excellent pharmacokinetic profile (%F: 66) in mice and efficacious in vivo in diet induced obese (DIO) mice model. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Quality Control of 3-Chloro-4-nitrobenzonitrile

The Article related to aryl sulfonamide preparation b0at1 neutral amino acid transporter inhibitor, b(0)at1, nimesulide, nitro group, trifluoromethyl sulfonyl, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Quality Control of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On September 25, 1992, Tsuji, Kiyoshi; Nakamura, Katsuya; Konishi, Nobukiyo; Okumura, Hiroyuki; Matsuo, Masaaki published an article.Safety of 3-Chloro-4-nitrobenzonitrile The title of the article was Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2′-phenoxymethanesulfonanilide derivatives. And the article contained the following:

Various 2′-phenoxymethanesulfonanilide derivatives I (R1 = H, NO2, CF3, CONH2, SEt, cyano, etc., R2 = H, COMe, Me) and II (R3-R5 = H, 2-F, 2,3-Cl2, 2-Br, 2-OMe, 2-SMe, etc.) were synthesized and evaluated for antiinflammatory and analgesic activities. Thus, 3-(2,4-difluorophenoxy)-4-nitrobenzonitrile reacted with Fe/NH4Cl/EtOH and MeSO2Cl/pyridine to give I (R1 = cyano, R2 = H). Some compounds bearing an electron-attracting substituent at the 4′-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4′-cyano-(FK867) and 4′-acetyl-(FK3311) 2′-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to phenoxymethanesulfonanilide preparation analgesic antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On December 15, 2010, Chandrappa, S.; Vinaya, K.; Ramakrishnappa, T.; Rangappa, K. S. published an article.Safety of 3-Chloro-4-nitrobenzonitrile The title of the article was An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride. And the article contained the following:

A novel, efficient Fe/CaCl2 system was revealed for the reduction of nitro-arenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation. The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, Me, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple exptl. procedure and easy purification make the protocol advantageous. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to nitro aryl reduction iron calcium chloride catalytic transfer hydrogenation, azo aromatic cleavage iron calcium chloride catalytic transfer hydrogenation, aryl amine preparation and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On April 25, 2002, Nakao, Kazunari; Okumura, Yoshiyuki; Matsumizu, Miyako; Uneo, Naomi; Hashizume, Yoshinobu; Kato, Tomoki; Kawai, Akiyoshi; Miyake, Yoriko; Nukui, Seiji; Shinjyo, Katsuhiro; Taniguchi, Kana published a patent.Recommanded Product: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of imidazoarenes as antiinflammatory and analgesic agents.. And the patent contained the following:

Title compounds [I; Y1-Y4 = N, CH, CL; R1 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (substituted) 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N, S, etc.; B = halo-substituted alkylene, cycloalklylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (substituted) monocyclic or bicyclic aryl optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.], were prepared as prostaglandin E2 receptor antagonists, preferably as EP4 receptor antagonists. Thus, to 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine (preparation given) in CH2Cl2 was added p-toluenesulfonyl isocyanate followed by stirring for 3 h to give 56% 2-ethyl-5,7-dimethyl-3-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-3H-imidazo[4,5-b]pyridine. Preferred I inhibited PGE2-induced thermal hyperalgesia in rats with ED50<60 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 3-Chloro-4-nitrobenzonitrile

The Article related to imidazoarene preparation antiinflammatory analgesic, prostaglandin receptor antagonist imidazoarene preparation, benzimidazole imidazopyridine preparation ep4 antagonist analgesic antiinflammatory and other aspects.Recommanded Product: 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On July 6, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.Recommanded Product: 34662-29-8 The title of the patent was Phenoxy-substituted alkanesulfonanilide derivatives useful as analgesics, antiinflammatories, and antipyretics, and processess for their preparation. And the patent contained the following:

Title derivatives I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkythio, -sulfinyl, -sulfonyl, alkoxy; R3 = alkyl, mono- or dialkylamino; R4 = acyl, cyano, CO2H, hydroxyalkyl, SH, alkylthio, -sulfinyl, -sulfonyl, 2-oxodioxolan-3-ylidenemethyl, CR6:NR7, (un)substituted 5-membered unsaturated heterocyclyl; SPh; R5 = H, halo, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, ureido, thiouredo] are prepared for use as analgesics, antiinflammatories, and antipyretics. 4-Amino-3-(2,4-difluorophenoxy)acetophenone was prepared in 4 steps and sulfonylated by MeSO2Cl in pyridine to give acetyl(difluorophenoxy)methanesulfonanilide II. In the adjuvant arthritis test in rats, II at 1.0 mg/kg/day orally inhibited secondary (uninjected) paw lesion by 50%, vs. only 24.7% by ibuprofen at 10.0 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenoxyalkanesulfonanilide preparation analgesic antiinflammatory antipyretic, alkanesulfonanilide phenoxy preparation analgesic antiinflammatory, sulfonanilide phenoxyalkane preparation analgesic antiinflammatory and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 25, 2002, Nakao, Kazunari; Okumura, Yoshiyuki; Matsumizu, Miyako; Uneo, Naomi; Hashizume, Yoshinobu; Kato, Tomoki; Kawai, Akiyoshi; Miyake, Yoriko; Nukui, Seiji; Shinjyo, Katsuhiro; Taniguchi, Kana published a patent.Recommanded Product: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of imidazoarenes as antiinflammatory and analgesic agents.. And the patent contained the following:

Title compounds [I; Y1-Y4 = N, CH, CL; R1 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (substituted) 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N, S, etc.; B = halo-substituted alkylene, cycloalklylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (substituted) monocyclic or bicyclic aryl optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.], were prepared as prostaglandin E2 receptor antagonists, preferably as EP4 receptor antagonists. Thus, to 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine (preparation given) in CH2Cl2 was added p-toluenesulfonyl isocyanate followed by stirring for 3 h to give 56% 2-ethyl-5,7-dimethyl-3-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-3H-imidazo[4,5-b]pyridine. Preferred I inhibited PGE2-induced thermal hyperalgesia in rats with ED50<60 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 3-Chloro-4-nitrobenzonitrile

The Article related to imidazoarene preparation antiinflammatory analgesic, prostaglandin receptor antagonist imidazoarene preparation, benzimidazole imidazopyridine preparation ep4 antagonist analgesic antiinflammatory and other aspects.Recommanded Product: 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 6, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.Recommanded Product: 34662-29-8 The title of the patent was Phenoxy-substituted alkanesulfonanilide derivatives useful as analgesics, antiinflammatories, and antipyretics, and processess for their preparation. And the patent contained the following:

Title derivatives I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkythio, -sulfinyl, -sulfonyl, alkoxy; R3 = alkyl, mono- or dialkylamino; R4 = acyl, cyano, CO2H, hydroxyalkyl, SH, alkylthio, -sulfinyl, -sulfonyl, 2-oxodioxolan-3-ylidenemethyl, CR6:NR7, (un)substituted 5-membered unsaturated heterocyclyl; SPh; R5 = H, halo, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, ureido, thiouredo] are prepared for use as analgesics, antiinflammatories, and antipyretics. 4-Amino-3-(2,4-difluorophenoxy)acetophenone was prepared in 4 steps and sulfonylated by MeSO2Cl in pyridine to give acetyl(difluorophenoxy)methanesulfonanilide II. In the adjuvant arthritis test in rats, II at 1.0 mg/kg/day orally inhibited secondary (uninjected) paw lesion by 50%, vs. only 24.7% by ibuprofen at 10.0 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenoxyalkanesulfonanilide preparation analgesic antiinflammatory antipyretic, alkanesulfonanilide phenoxy preparation analgesic antiinflammatory, sulfonanilide phenoxyalkane preparation analgesic antiinflammatory and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts