Category: 34662-29-8

On June 8, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Name: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Name: 3-Chloro-4-nitrobenzonitrile

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: 3-Chloro-4-nitrobenzonitrile

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On November 30, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo; Okumura, Hiroyuki published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of alkanesulfonanilides as analgesics and antiinflammatories. And the patent contained the following:

The title compounds [I; Ar = Q; R1 = alkyl, haloalkyl; R2 = acyl, cyano, CO2H, (un)substituted alkyl, etc.; R3 = H, NO2, alkyl, halo; R4-R7 = H, halo, haloalkyl, alkoxy, (un)substituted heterocyclyl; X = S(O)n, NHCO, CONH, R8N, R9CH; R8 = H, alkyl; R9 = H, OH; n = 0-2] and their pharmaceutically acceptable salts were prepared NaBH4 was added to 4′-acetyl-2′-[(2,4-difluorophenyl)thio]methanesulfonanilide in MeOH, and the mixture stirred overnight at room temperature and treated with AcOH to give 2′-[(2,4-difluorophenyl)thio]-4′-(1-hydroxyethyl)methanesulfonanilide (II). In rats 10 mg II/kg orally gave 90.1% inhibition of secondary lesions induced by Mycobacterium聽tuberculosis, a measure of antiinflammatory activity. 4′-Acetyl-2′-[(2,4-difluorophenyl)amino]methanesulfonanilide, also prepared, had an analgsic ED50 of 1.8 mg/kg orally in the mouse writhing test. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to alkanesulfonanilide preparation analgesic antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On September 25, 1992, Tsuji, Kiyoshi; Nakamura, Katsuya; Konishi, Nobukiyo; Okumura, Hiroyuki; Matsuo, Masaaki published an article.Safety of 3-Chloro-4-nitrobenzonitrile The title of the article was Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2′-phenoxymethanesulfonanilide derivatives. And the article contained the following:

Various 2′-phenoxymethanesulfonanilide derivatives I (R1 = H, NO2, CF3, CONH2, SEt, cyano, etc., R2 = H, COMe, Me) and II (R3-R5 = H, 2-F, 2,3-Cl2, 2-Br, 2-OMe, 2-SMe, etc.) were synthesized and evaluated for antiinflammatory and analgesic activities. Thus, 3-(2,4-difluorophenoxy)-4-nitrobenzonitrile reacted with Fe/NH4Cl/EtOH and MeSO2Cl/pyridine to give I (R1 = cyano, R2 = H). Some compounds bearing an electron-attracting substituent at the 4′-position strongly inhibited adjuvant-induced arthritis in rats and acetic acid-induced writhing syndrome in mice without causing gastro-intestinal irritation. Among them, 4′-cyano-(FK867) and 4′-acetyl-(FK3311) 2′-(2,4-difluorophenoxy)methanesulfonanilides were selected as the candidates for further development. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to phenoxymethanesulfonanilide preparation analgesic antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 1, 2021, Desai, Jigar; Patel, Bhaumin; Darji, Brijesh; Gite, Archana; Panchal, Nandini; Bhosale, Gokul; Shedage, Sandeep; Patel, Sandip; Kadam, Pravin; Patel, Gautam; Kumar Srivastava, Brijesh; Joharapurkar, Amit; Kshirsagar, Samadhan; Giri, Poonam; Bhayani, Hitesh; Patel, Ankit; Ghoshdastidar, Krishnarup; Bandyopadhyay, Debdutta; Kumar, Sanjay; Jain, Mukul; Sharma, Rajiv published an article.Quality Control of 3-Chloro-4-nitrobenzonitrile The title of the article was Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19). And the article contained the following:

Rationally designed trifluoromethylsulfonyl derivatives were identified as novel, potent and orally bioavailable B0AT1 (neutral amino acid transporter) inhibitors. The compound I was found to be nanomolar potent (IC50: 0.035渭M) B0AT1 inhibitor with excellent pharmacokinetic profile (%F: 66) in mice and efficacious in vivo in diet induced obese (DIO) mice model. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Quality Control of 3-Chloro-4-nitrobenzonitrile

The Article related to aryl sulfonamide preparation b0at1 neutral amino acid transporter inhibitor, b(0)at1, nimesulide, nitro group, trifluoromethyl sulfonyl, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Quality Control of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
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On January 25, 1990, Yoshikawa, Yoshinari; Ochi, Yutaka; Sekiuchi, Kazuto; Saito, Hideji; Hatayama, Katsuo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of sulfonanilide derivatives as antiinflammatory agents. And the patent contained the following:

Sulfonanilides [I; R1 = C1-4 alkyl; R2 = C1-4 alkyl, Ph, AR4 wherein R4 = Ph, halo-substituted Ph or cycloalkyl, A = O, S; R3 = halo, haloalkyl, Ph, CHO, alkoxycarbonyl, etc.] are prepared Reduction of 5.0 g nitro compound II (R = NO2) in EtOH over 5% Pd-C gave 4.4 g amine II (R = NH2), which (3.3 g) was diazotized and the diazonium salt treated with KCN to give 1.2 g cyano compound II (R = cyano) (III). III at 50 mg/kg p.o. showed 48.9% inhibition of carrageenan-induced edema in rats, vs. 41.6% inhibition with ibuprofen. Also prepared were 35 addnl. I. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8

The Article related to sulfonanilide preparation antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 34662-29-8

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Nitrile – Wikipedia,
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On December 15, 2010, Chandrappa, S.; Vinaya, K.; Ramakrishnappa, T.; Rangappa, K. S. published an article.Safety of 3-Chloro-4-nitrobenzonitrile The title of the article was An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride. And the article contained the following:

A novel, efficient Fe/CaCl2 system was revealed for the reduction of nitro-arenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation. The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, Me, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple exptl. procedure and easy purification make the protocol advantageous. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to nitro aryl reduction iron calcium chloride catalytic transfer hydrogenation, azo aromatic cleavage iron calcium chloride catalytic transfer hydrogenation, aryl amine preparation and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

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On October 9, 2002, Dombroski, Mark Anthony; Laird, Ellen Ruth; Letavic, Michael Anthony; McClure, Kim Francis published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of novel benzotriazoles as anti-inflammatory compounds. And the patent contained the following:

The title compounds [I; Het = (un)substituted pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = H, alkyl, Ph, etc.; s = 0-5] which are potent inhibitors of MAP kinases, preferably p38 kinase (no data given), and are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders, were prepared Thus, treating a solution of 3-isopropyl-3H-benzotriazole-5-carbaldehydein THF with concentrate NH4OH followed by addition of piperazine and isocyanide II afforded III. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to benzotriazole preparation map p38 kinase inhibitor antiinflammatory, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 30, 2020, Wang, Wenlong; Li, Jia; Zhou, Yubo; Yu, Lijie; Meng, Xiangdong; Feng, Bo; Wang, Zhijia; Wu, Jing published a patent.Application of 34662-29-8 The title of the patent was Preparation and pharmaceutical applications oxadiazole derivatives. And the patent contained the following:

The present invention relates to the preparation of oxadiazole derivatives, a pharmaceutical composition and application, and belongs to the tech. field of medicine. In particular, oxadiazoles I [wherein, X1, X2, X3, X4 are each independently selected from N, CR1, CR2, CR3; wherein R1, R2, R3 are each independently selected from substituted aromatic ring, NHR4, COR5, -CH2NHRa, etc., where Ra is (un)substituted furanyl, (un)substituted tetrahydrofuranyl, thienyl etc.]. Further [substituted aromatic ring, substituted heteroaromatic ring, substituted alkenyl and substituents on substituted cyclopropyl are independently selected from -F, -Cl, mono- or di-substituted NHCOR6 etc., where R4 is (un)substituted C1-6 alkyl, R5 is C1-6 alkoxy or C1-10 alkylamino or aromatic ring substituted benzylamino or substituted anilino, R6 is (un)substituted furanyl, thienyl, chloromethyl, etc.; or substituted aromatic ring is 1-methyl-2,3-dioxo-4H-quinoxalin-6-yl, 4-(1-piperidyl)phenyl, 1-isopropyl-2,3-dioxo-4H-quinoxalin-6-yl, etc.] were prepared The oxygen-containing five-membered heterocycle of the present invention has the biol. activity of inhibiting protein tyrosine phosphatase SHP2, and can be used as a tool compound to study the biol. function relevance of protein tyrosine phosphatase SHP2 in the process of cell signal transduction, for prevention and provide new methods for the treatment of cancer, metabolism and immune diseases. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to oxadiazole derivative preparation protein tyrosine phosphatase shp inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 34662-29-8

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Shi, Wei-Min; Liu, Feng-Ping; Wang, Zhi-Xin; Bi, Hong-Yan; Liang, Cui; Xu, Li-Ping; Su, Gui-Fa; Mo, Dong-Liang published an article in 2017, the title of the article was Synthesis of 1-Vinyl/Arylbenzotriazole 3-Oxides through a Copper-Mediated C-N Bond Coupling Reaction.COA of Formula: C7H3ClN2O2 And the article contains the following content:

An efficient synthesis of 1-vinyl/arylbenzotriazole 3-oxides, e.g., I via the copper-promoted coupling of N-hydroxybenzotriazoles with alkenyl- or arylboronic acids is reported. This strategy features mild reaction conditions, good functional group tolerance, broad substrate scope and rapid introduction of benzotriazole N-oxide moieties into mols. D. functional theory calculations revealed that the formation of the favored N-coupling product depends on the kinetically more favorable C-N bond formation pathway. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2

The Article related to vinylbenzotriazole arylbenzotriazole oxide preparation, hydroxybenzotriazole alkenylboronic arylboronic acid coupling copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C7H3ClN2O2

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Nitrile – Wikipedia,
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On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Recommanded Product: 34662-29-8 The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts