Category: 34662-29-8

On August 20, 2014, Han, Shiqing; Tong, Yao; Pan, Qiang; Jiang, Zengqiang; Miao, Dazhuang published a patent.COA of Formula: C7H3ClN2O2 The title of the patent was A synthetic method for 2-substituted benzothiazole derivatives. And the patent contained the following:

The invention relates to a process for the preparation of 2-substituted benzothiazole derivatives via heterocyclization of 2-halogenated nitrobenzene with elemental sulfur and aliphatic amines. For instance, 2-phenyl-benzothiazole was prepared from 1-chloro-2-nitrobenzene, sulfur, and benzylamine in 76% yield as a white solid. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2

The Article related to benzothiazole preparation heterocyclization halonitrobenzene benzylamine sulfur, heterocyclization and other aspects.COA of Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Darmanin, Thierry; Godeau, Guihem; Guittard, Frederic; Klimareva, Elena L.; Schewtschenko, Irina; Perepichka, Igor F. published an article in 2018, the title of the article was A Templateless Electropolymerization Approach to Porous Hydrophobic Nanostructures Using 3,4-Phenylenedioxythiophene Monomers with Electron-Withdrawing Groups.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile And the article contains the following content:

Controlling the surface structures of conducting polymers is extremely important for various applications not only because of their unique optoelectronic properties but also owing to the wetting properties of these materials. Using a templateless electropolymerization approach, we report the formation of porous polymer nanostructures from a series of 3,4-(1,2-phenylenedioxy)(PheDOT) derivatives with electron-withdrawing side groups (Cl, CN, CF, SOCH). In this templateless electropolymerization, trace water present in solution is sufficient to produce gas bubbles (O2 and H2) and, as a consequence, to form the porous nanostructures with a tendency to form nanotubes on the surface. We show that the substituents in PheDOT play an important role to control the porous nanostructures and, as a consequence, the surface hydrophobicity. Using 3,4-(1,3-propylenedioxy)type (ProDOT) derivative F4-BnDOT, the formation of densely packed nanofibers was demonstrated, and these are not a result of the presence of trace water. In this case, the surfaces are even more hydrophobic than for PheDOT-based polymers, displaying extremely high apparent water contact angles (θw = 138-144 °) and strong water adhesion. Such surfaces from electropolymerized conducting polymers could be used in a number of technol. applications, e.g. self-cleaning surfaces, micropatterning, water harvesting and microfluid systems. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to phenylenedioxythiophene monomer derivative electron withdrawing group templateless electropolymerization property, Chemistry of Synthetic High Polymers: Ring-Opening and Other Polymerizations and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 12, 2004, Blazej, Sylwia; Kwast, Andrzej; Makosza, Mieczyslaw published an article.Reference of 3-Chloro-4-nitrobenzonitrile The title of the article was cine-Substitution of the nitro group in 2,4-disubstituted nitroarenes with carbanions of aryl alkyl sulfones. And the article contained the following:

Rapid protonation of short lived σH adducts, e.g., I, derived from the nucleophilic addition of aryl alkyl sulfones to 2,4-disubstituted nitrobenzenes, resulted in elimination of nitrous acid giving 1,3,5-trisubstituted benzenes, e.g., II, as products of cine-substitution of the nitro group. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to nitrobenzene aryl alkyl sulfone cine substitution, aryl arylalkyl sulfone preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfoxides and Sulfones and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 24, 2012, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Synthetic Route of 34662-29-8 The title of the patent was Process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1h-indole-5-carbonitrile 701. And the patent contained the following:

The present invention relates to a new process for the manufacture of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1H-indole-5-carbonitrile citrate, and to new intermediates prepared in said process suitable for large scale manufacturing of said compound The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 30, 2008, Delisser, Vern; Hedberg, Martin; Jansson, Annette; Raadevik, Andreas; Ryberg, Per; Thiering, Swantje published a patent.Category: nitriles-buliding-blocks The title of the patent was Process for preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile. And the patent contained the following:

The present invention pertains to a process for the preparation of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile as a free base and pharmaceutically acceptable salts thereof, particularly the citrate salt. For example, Et 2-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]acetate was reacted with 3-fluoro-4-nitrobenzonitrile in THF at -20 °C in presence of lithium tert-butoxide to afford an intermediate, which was treated with Degussa heterogeneous catalyst (platinum and vanadium on active carbon) under hydrogen for selective reduction of nitro group to amino group. The reduction product obtained above was treated with citric acid monohydrate at 60-75 °C for 2 h in Bu acetate, DMF, and iso-propanol, cooled to 5 °C over 10 h, and held overnight at 5 °C to gave 75 % yield of 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile citrate as an orange solid. Advantageously, the new process is suitable for large scale industrial manufacturing The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Category: nitriles-buliding-blocks

The Article related to preparation morpholin indole citrate, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 14, 2004, Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of heterocyclic bicyclic compounds as NR2B receptor antagonists. And the patent contained the following:

Title compounds I [R1-2 = H, halo, alkyl, alkoxy, etc.; X = bond, alkylene, etc.; A = bicyclic, aromatic, (un)saturated heterocyclic ring, etc.; B = Ph, heteroaryl, etc.] are prepared For instance, N-[(2-benzyl-1H-indol-5-yl)methyl]-4-hydroxybenzamide (II)is prepared in 2 steps from (2-benzyl-1H-indol-5-yl)carbonitrile. II has Ki = 2 nM for the NR2B receptor. I is useful for the treatment of disease conditions caused by over activation of NMDA NR2B receptor, e.g., pain. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to bicyclic benzimidazole benzoxazole quinazoline nr2b receptor antagonist preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 30, 2020, Wang, Wenlong; Li, Jia; Zhou, Yubo; Yu, Lijie; Meng, Xiangdong; Feng, Bo; Wang, Zhijia; Wu, Jing published a patent.Application of 34662-29-8 The title of the patent was Preparation and pharmaceutical applications oxadiazole derivatives. And the patent contained the following:

The present invention relates to the preparation of oxadiazole derivatives, a pharmaceutical composition and application, and belongs to the tech. field of medicine. In particular, oxadiazoles I [wherein, X1, X2, X3, X4 are each independently selected from N, CR1, CR2, CR3; wherein R1, R2, R3 are each independently selected from substituted aromatic ring, NHR4, COR5, -CH2NHRa, etc., where Ra is (un)substituted furanyl, (un)substituted tetrahydrofuranyl, thienyl etc.]. Further [substituted aromatic ring, substituted heteroaromatic ring, substituted alkenyl and substituents on substituted cyclopropyl are independently selected from -F, -Cl, mono- or di-substituted NHCOR6 etc., where R4 is (un)substituted C1-6 alkyl, R5 is C1-6 alkoxy or C1-10 alkylamino or aromatic ring substituted benzylamino or substituted anilino, R6 is (un)substituted furanyl, thienyl, chloromethyl, etc.; or substituted aromatic ring is 1-methyl-2,3-dioxo-4H-quinoxalin-6-yl, 4-(1-piperidyl)phenyl, 1-isopropyl-2,3-dioxo-4H-quinoxalin-6-yl, etc.] were prepared The oxygen-containing five-membered heterocycle of the present invention has the biol. activity of inhibiting protein tyrosine phosphatase SHP2, and can be used as a tool compound to study the biol. function relevance of protein tyrosine phosphatase SHP2 in the process of cell signal transduction, for prevention and provide new methods for the treatment of cancer, metabolism and immune diseases. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to oxadiazole derivative preparation protein tyrosine phosphatase shp inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 9, 2002, Dombroski, Mark Anthony; Laird, Ellen Ruth; Letavic, Michael Anthony; McClure, Kim Francis published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of novel benzotriazoles as anti-inflammatory compounds. And the patent contained the following:

The title compounds [I; Het = (un)substituted pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = H, alkyl, Ph, etc.; s = 0-5] which are potent inhibitors of MAP kinases, preferably p38 kinase (no data given), and are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders, were prepared Thus, treating a solution of 3-isopropyl-3H-benzotriazole-5-carbaldehydein THF with concentrate NH4OH followed by addition of piperazine and isocyanide II afforded III. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to benzotriazole preparation map p38 kinase inhibitor antiinflammatory, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shi, Wei-Min; Liu, Feng-Ping; Wang, Zhi-Xin; Bi, Hong-Yan; Liang, Cui; Xu, Li-Ping; Su, Gui-Fa; Mo, Dong-Liang published an article in 2017, the title of the article was Synthesis of 1-Vinyl/Arylbenzotriazole 3-Oxides through a Copper-Mediated C-N Bond Coupling Reaction.COA of Formula: C7H3ClN2O2 And the article contains the following content:

An efficient synthesis of 1-vinyl/arylbenzotriazole 3-oxides, e.g., I via the copper-promoted coupling of N-hydroxybenzotriazoles with alkenyl- or arylboronic acids is reported. This strategy features mild reaction conditions, good functional group tolerance, broad substrate scope and rapid introduction of benzotriazole N-oxide moieties into mols. D. functional theory calculations revealed that the formation of the favored N-coupling product depends on the kinetically more favorable C-N bond formation pathway. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2

The Article related to vinylbenzotriazole arylbenzotriazole oxide preparation, hydroxybenzotriazole alkenylboronic arylboronic acid coupling copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Recommanded Product: 34662-29-8 The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts