Category: 34662-29-8

On May 3, 2018, Harried, Scott S.; Resnick, Lynn; Topalov, George T.; Boyd, Steven A.; Belardi, Justin K.; Flentge, Charles A.; Hale, James S.; Mareska, David A.; Zhang, Kai published a patent.Name: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of benzoimidazolylamide derivatives for use as Kv7 potassium channel activators. And the patent contained the following:

Title compounds I [A = alkyl; X = H, F, alkyl, or (un)substituted Ph; Y = H, F, or a moiety having a mol. weight of 15 Da to 300 Da and consisting of 2-5 chem. elements, wherein the chem. elements are independently C, H, O, or F; Z = (un)substituted cyclobutyl, Ph, iso-Pr, or t-butyl; R1 = CN, OMe, CF3, etc.; R2, R3, and R4 independently = H, F, Cl, etc.], and their pharmaceutically acceptable salts, are prepared and disclosed as Kv7 potassium channel activators. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in Kv7.2/7.3 activation assays (data given). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Name: 3-Chloro-4-nitrobenzonitrile

The Article related to benzoimidazolylamide preparation kv7 potassium channel activator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 12, 2011, Hallman, Jason; Laudeman, Christopher; Liu, Ronggang; Miller, Aaron; Moore, Michael Lee; Dock, Steven; Musso, David; Parrish, Cynthia published a patent.Formula: C7H3ClN2O2 The title of the patent was Benzimidazoles as fatty acid synthase inhibitors and their preparation and use for the treatment of cancer. And the patent contained the following:

The invention relates to benzimidazole derivatives of formula I, which are fatty acid synthase inhibitors and which are useful in the treatment of cancer. Compounds of formula I wherein each R1 is independently halo, C1-6 alkyl, alkoxy, CN, etc.; R2 is (un)substituted aryl and (un)substituted heteroaryl; R3 is amino, alkylamino, dialkylamino, etc.; each R4 is C1-6 alkyl, alkoxy, OH and halo; each Y is independently C and N; n is 0 to 4; m is 0 to 4; provided that at least two Y are C; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their fatty acid synthase inhibitory activity. From the assay, it was determined that compound II exhibited a pIC50 value of 7.26. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to benzimidazole preparation fatty acid synthase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2008, Efremov, Ivan Viktorovich; Rogers, Bruce Nelsen; Duplantier, Allen Jacob; Zhang, Lei; Zhang, Qian; Maklad, Noha Serour; Evrard, Edelweiss Virginie; Brodney, Michael A. published a patent.Formula: C7H3ClN2O2 The title of the patent was Benzimidazolyl compounds as potentiators of mGluR2 subtype of glutamate receptor and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. Compounds of formula I wherein X1 is CR7; X2 is CR4; X3 is CR6; X4 is (CHR9)0-2; X5 is CH2, CH2CH2; X8 is CR3; R1, R2, R3, R4 and R6 are independently H, halo, CN, OH and derivatives, alkyl, alkenyl, etc.; R7 is H, halo, OH, alkyl, alkoxy, CN and alkyl-CO; R5, R8 and R9 are independently halo, CN, OH and derivatives, CO2H and derivatives, NH2 and derivatives, H, alkyl, alkenyl, etc.; R11, R12, R13 and R14 are independently halo, CN, H, CO2H and derivatives, CONH2 and derivatives, OH and derivatives, NH2 and derivatives, alkyl, etc.; R17 is (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, and (un)substituted cycloalkenyl; R18 is H, halo and alkyl; R19 are H; R8R19 taken together to form =O; and their pharmaceutically acceptable salts thereof, are claimed. Example compound II•HCl was prepared by reductive alkylation of 4-(2-methoxy-4-trifluoromethylphenyl)piperidine hydrochloride with 1-methyl-1H-benzo[d]imidazole-2-carboxaldehyde. All the invention compounds were evaluated for their ability to potentiate mGluR2. From the assay, it was determined that compound II exhibited EC50 value of < 0.0193 μM. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to benzimidazolyl compound preparation potentiator mglur2 treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 23, 2003, Shimojo, Masato; Taniguchi, Kana published a patent.Related Products of 34662-29-8 The title of the patent was Preparation of imidazoarenes as prostaglandin E2 subtype EP4 receptor antagonists for treatment of IL-6 involved diseases. And the patent contained the following:

The present invention relates to the use of a prostaglandin E2 (PGE2) subtype EP4 receptor ligand in the manufacture of a medicament for the treatment of interleukin 6 (IL-6) involved diseases, such as alc. cirrhosis, amyloidosis, atherosclerosis, cardiac disease, sclerosis, and organ transplantation reactions (no data). The invention also relates to the assay which comprises culturing peripheral whole blood with a test compound and determining the effect of the compound on PGE2-induced whole blood cells activation. Three hundred eighty title compounds I [wherein Y1-Y4 = N, CH, CL; R1 = H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (un)substituted 5-6 membered (un)substituted monocyclic (hetero)aromatic ring; B = halo-substituted alkylene, cycloalkylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo or alkyl group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (un)substituted monocyclic or bicyclic (hetero)aryl; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.] were prepared Thus, cycloaddition of 2-[4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl]ethanol (4-step preparation given) with propionyl chloride in toluene provided 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethyl propionate, which was treated with aqueous LiOH to give the ethanol derivative (86%). Chlorination (90%) using thionyl chloride, conversion to the azide (85%), and Pd/C catalyzed hydrogenation afforded the amine (94%). Coupling of the amine with p-toluenesulfonyl isocyanate in CH2Cl2 gave II (56%). The latter significantly inhibited IL-6 secretion by PGE2 in ConA-stimulated human peripheral blood mononuclear cells (PBMC). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Related Products of 34662-29-8

The Article related to imidazoarene preparation composition prostaglandin e2 ep4 antagonist, benzimidazole imidazopyridine preparation composition il6 disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Related Products of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2009, Kaspady, Mohamed; Narayanaswamy, Venugopala Katharigatta; Raju, Mohana; Rao, Gopal Krishna published an article.Synthetic Route of 34662-29-8 The title of the article was Synthesis, antibacterial activity of 2,4-disubstituted oxazoles and thiazoles as bioisosteres. And the article contained the following:

Two series of 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole (2a-k) and thiazole (4a-k) mol. scaffolds containing divalent bioisosteres, viz., oxygen and sulfur were synthesized by condensing substituted amides and thioamides with substituted phenacyl bromide in absolute ethanol medium. The structure of newly synthesized compounds was characterized by anal. and spectral (IR, 1H-NMR, 13C-NMR and LC-MS) methods. The synthesized compounds were evaluated for qual. (zone of inhibition) and quant. antibacterial activity (MIC) by agar cup plate and micro-titration methods, resp. Preliminary pharmacol. observations revealed that some of the substituents such as 2-alkyl and heteroaryl at second position, chloro and bromo at the fourth position of the aryl moiety and a divalent sulfur atom in the five-membered heterocyclic ring system influenced significantly the antibacterial activity when compared to its bioisostere counterpart 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole systems. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to antibacterial oxazole thiazole preparation sar, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On September 30, 2009, Goeker, Hakan; Alp, Mehmet; Ates-Alagoez, Zeynep; Yildiz, Sulhiye published an article.Application of 34662-29-8 The title of the article was Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles. And the article contained the following:

A series of 47 novel N1-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogs were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that I and II, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogs III (R1 = H, R2 = Br; R1 = Pr, R2 = Br, CN) have no inhibitory activity. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to benzimidazole preparation nucleophilic substitution reduction aryl diamine benzaldehyde heterocyclization, fungal infection antifungal structure activity candida, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On July 1, 2010, Li, Jianqi; Wang, Guan; Zhang, Guisen; Lv, Na; Jiao, Guangjun; Liu, Shicheng; Zhou, Shixia published a patent.Electric Literature of 34662-29-8 The title of the patent was Preparation of piperidinyl benzisoxazole derivatives as inhibitors of 5-HT2A receptor. And the patent contained the following:

The invention provides piperidinyl benzisoxazole derivatives with formula I [R = H, halo, (un)substituted alkyl, or alkoxy; X and Y independently = CH or N; Ra = H, halo, CN, (un)substituted alkyl, alkoxy, etc,], and their salts and hydrates, are prepared and disclosed. The invention compounds has antagonistic effect on 5-HT2A and has mediating effect on 5-hydroxytryptamine system such as reuptake inhibiting effect of 5-HT and so on. Thus, e.g., II was prepared by condensation reaction of N-(4-chlorobutyl)indole with 4-(6-fluorobenzisoxazol-3-yl)piperidine. II exhibited affinity to 5-HT2A with IC50 value of 1.659 nM and Ki value of 1.9806 nM. The compounds of the invention possess excellent analgesia, sedation activity, minimal toxicity and side effects. The invention also provides pharmaceutical compositions comprising the derivatives and their use. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Electric Literature of 34662-29-8

The Article related to benzisoxazole piperidinyl preparation 5hta receptor inhibitor pain, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Electric Literature of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Safety of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of aminoethoxybenzoxazole derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

Title compounds I [X = S or O; R1 = H, alkyl, CF3, OH , etc.; R2 = H, alkyl, halo, or CN; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)saturated, (un)substituted carbon chain wherein one carbon atom may optionally be replaced with a N atom; Ar = aryl or heteroaryl], and their pharmaceutically acceptable salts, are prepared and disclosed to possess capability of both serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. Thus, e.g., II was prepared by reaction of 2-(4-iodobutoxy)benzonitrile with the corresponding amine (preparation given). I are evaluated by dopamine-D2 and 5-HT reuptake binding assays, e.g., II demonstrate pKi values of 7.9 and 7.4 resp. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to aminoethoxy benzoxazole preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent aminoethoxybenzoxazole amine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grivsky, Eugene M.; Hitchings, George H. published an article in 1974, the title of the article was Syntheses of 2-chloro-4-acetylaminobenzonitrile isomers and structurally related compounds with biological activities.Quality Control of 3-Chloro-4-nitrobenzonitrile And the article contains the following content:

Benzonitriles I, II, and III (Xn = 2-,3-Cl, 2-F, 2,6-, 2,4 -Cl2; NH2, NHCOR, NO2 in 2, 4, or 5 position; R = e.g., Me, H, CF3, CHCl2, CH2Cl, Et, Me2CH, Pr, CH:CHCO2H, CH2CH2CO2H) were prepared (5 I, 15 II and 88 III). E.g., reaction of 2,4-F-(O2N)C6H3CO2H with MeSO2NH2-PCl5 gave 96% I (Xn = 2-F, 4-NO2), which was reduced to give II (Xn = 2-F, 4-NH2), which was acetylated to give 95% III (Xn = 2-F, R = Me). III (Xn = 2-Cl, NHCOMe in 4 position) had LD50 (oral-mice)of 1800 mg/kg; and at 20 mg/kg (oral-mice) was an antide-pressant and at 25 and 50 mg kg (orally-rat), resp., was an anal-gesic and antipyretic. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Quality Control of 3-Chloro-4-nitrobenzonitrile

The Article related to acetanalide cyano halo analgesic, antipyretic chloroacetamidobenzonitrile, antidepressant chloroacetamidobenzonitrile, Noncondensed Aromatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Quality Control of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 16, 2021, Reutskaya, Elena; Sapegin, Alexander; Peintner, Stefan; Erdelyi, Mate; Krasavin, Mikhail published an article.Synthetic Route of 34662-29-8 The title of the article was Sulfur Oxidation Increases the Rate of HIRE-Type [1.4]Thiazepinone Ring Expansion and Influences the Conformation of a Medium-Sized Heterocyclic Scaffold. And the article contained the following:

The hydrated imidazoline ring expansion (HIRE-type) reaction was investigated for a series of di(hetero)arene-fused [1.4]thiazepinones in comparison with their sulfone counterparts. The sulfones were found to undergo ring expansion at a much higher rate compared to the thioethers, much in line with the current mechanistic understanding of the process. Moreover, the amide bond cis- and trans-isomers of the ring-expanded products were found, in the case of sulfones, to be stabilized through an intramol. hydrogen bond. The latter phenomenon was studied in detail by NMR experiments and corroborated by X-ray crystallog. information. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8

The Article related to thiazepinone hydrated imidazoline ring expansion conformation sulfone, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Synthetic Route of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts