Category: 34662-29-8

Greizerstein, W.; Bonelli, R. A.; Brieux, J. A. published an article in 1962, the title of the article was Polar effects of substituents on the reaction rates of 4-R and 5-R-2-nitrochlorobenzenes with pipefidine in benzene.Formula: C7H3ClN2O2 And the article contains the following content:

The rate constants for the reaction of fourteen 4-Rand of twelve 6-R-2-nitrochlorobenzenes with piperidine in benzene solution were determined The reactions were carried out at constant temperature in sealed tubes each containing 10 ml. benzene solution of the reactants, 0.1M in the halogen compound and 1.0M in piperidine. Cl- was determined by potentiometric titration after addition of 10 ml. 20% HNO3. Rate constants were calculated by means of the equation k2 = {2.303/[t(b – 2a)]} log {a(b – 2x)/b(a – x)}, where a and b were the molar concentrations of the halogen compound and piperidine, rasp., and x the concentration of Cl- at time t. Data from duplicate runs did not differ by more than 1% and rate constants were reproducible within ±2% by independent experiments A spectrophotometric technique was used for compounds having the substituents: 4-NO2, 3-CN, 4-CO2Et, 4-PhN:N, 4-F3C, and 5-CN. The absorption due to the substituted N-phenylpiperidine produced in the reaction was measured at 390420 mμ with a Beckman DU spectrophotometer. Initial concentrations ranged from 10-4 to 10-5M for the halogen compound and piperidine was 102-103 times in excess. Samples were removed from the thermostat, cooled rapidly to room temperature, and the absorbency measured directly. Pseudomonomol. rate constants were calculated graphically from the plot of O.D.∞exptl.-O.D.t; versus t (O.D, = optical d.); second-order rate constants were obtained from these by dividing by the concentration of piperidine. The results were tabulated and showed that in the nucleophilic substitution of these compounds the polarity of the substituted carbon atom was mainly determined by the overall polar effect of the substituent. The reaction followed the Hammett relationship log kR/kH = σ*ρ. Using Jaffe’s σ* values, which are equivalent to Hammett’s σ-constants for most substituents studied, a ρ-value of +3.80 with a correlation coefficient r = 0.934 resulted. For the 4-R-2-nitrochlorobenzenes, alone a ρ-constant of +4.08 with a correlation coefficient of 0.922 was obtained. In order to estimate the mesomeric interaction between a 5-substituent R and the nitro group para to each other, the values of log k2-5R versus σ*meta were introduced into Hammett’s graphic plot of log k2-4R versus σ*4R with ρ = 4.08. From this, the difference between σ*meta values employed and the amended σ-values fitting the exptl. data into the equation log k2-5R = log k2-H + 4.08. σamended was evaluated for each m-substituent. The differences for most substituents were small, but for m-CN, m-CO2Et, and m-Ph the σamended values were smaller than the σ-constants by 0.24, 0.20, and 0.20 units, resp., showing that the activating influence of the nitro group ortho to the site of reaction was roughly constant but smaller than the overall effect in most compounds studied. 4-Chloro-3-nitrobenzotrifluoride and 4-chloro-3-nitroazobenzene showed an inversion of relative reactivity between 35 and 45°, but the order for the more reactive compounds at 45°, k4-No2 > k4-CN > k4-CO2Et > k4-F3C gt; k4-C6H5N2 > k4-CO2H gt; k4-halogen was that expected from their total polar effects upon the site of substitution. The 3-chloro-4-nitrobenzoic acid reacted slower than the p- and o-substituted isomer. The substituents 4-OMe, 4-OEt, and 4-NH2 were found to be deactivating by their mesomeric effect, while halogens produced a marked increase in the rate, specially from the m-position, due to their neg. inductive effect. A Me group in the m-position gave a slight decrease of the rate, this being more pronounced if Me was in the p-position. The phenyl group slightly enhanced the reactivity from the m-positions, a greater increment being observed from the p-position. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

3-Chloro-4-nitrobenzonitrile(cas:34662-29-8) belongs to nitriles. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grivsky, E. M. published an article in 1971, the title of the article was Convenient synthesis of chloronitrobenzonitrile isomers and homologs.Application of 34662-29-8 And the article contains the following content:

Ten position isomers of chloronitrobenzonitrile and some homologs were prepared from the corresponding benzoic acids and MeSO2NH2 in the presence of PCl5. This method was more generally applicable than the previous procedure using p-toluenesulfonamide and the products were obtained in amounts approaching the theoretical yields. A cyclic mechanism for a transformation leading to the formation of these aromatic nitriles was postulated. Thus, 0.1 mole 3-chloro-5-nitrobenzoic acid was treated with 0.1 mole MeSO2NH2 and 0.2 mole PCl5. After an initial exothermic reaction during which the internal temperature rose to 50-60°, the mixture was heated 30 min at 180° and the product worked up to give 3-chloro-5-nitrobenzonitrile (I). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

3-Chloro-4-nitrobenzonitrile(cas:34662-29-8) belongs to nitriles. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Day, Michael; Peters, Arnold Thornton published an article in 1967, the title of the article was Synthesis and ultraviolet spectra of nitrodiphenyl-amine disperse dyes. II. Synthesis of some substituted 2- and 4-nitrodiphenylamines.Reference of 3-Chloro-4-nitrobenzonitrile And the article contains the following content:

The synthesis of some substituted 2- and 4-nitrodiphenylamines, yellow dyes for synthetic fibers, is described. Condensation of 0.02 mole 2,5-Cl2C6H3NO2 with 0.04 mole PhNH2 in 50 ml. boiling EtOH containing 3 g. NaOAc gave 52.8% I (R = NO2, R1 = Cl, R2 = R3 = R4 = H), m. 59-60° (75% aqueous alc.). Other I were prepared similarly (R, R1, R2, R3, R4, % yield, and m.p. given): NO2, Cl, OMe, H, H, 50, 100-1°; NO2, Cl, H, OMe, H, 37, 90°; NO2, Cl, H, H, OMe, 48, 118-19°; NO2, Cl, F, H, H, 21, 113-14°; NO2, Cl, H, F, H, 40, 99-100°; NO2, Cl, H, H, F, 38, 80-1°; NO2, Cl, H, H, SO2Me, 15, 210-11°; CF3, NO2, H, H, H, 71, 63-4°; CF3, NO2, OMe, H, H, 16, 106-7°; CF3, NO2, H, OMe, H, 32, 88°; CF3, NO2, H, H, OMe, 74, 87-8°; CF3, NO2, F, H, H, 30, 60-1°; CF3, NO2, H, F, H, 57, 73-4°; CF3, NO2, H, H, F, 20, 74-5°; MeSO2, NO2, H, H, H, 82, 169-70°; Me, NO2, H, H, H, 23, 133-4°; NO2, Me, H, H, H, 79, 34-5°; NO2, OMe, H, H, H, 23, 44-5°. Fusion of 0.02 mole 3,4-Cl2C6H3NO2 (II) with 0.04 mole PhNH2 gave 31.8% I (R = Cl, R1 = NO2, R2 = R3 = R4 = H), m. 112-13°. Other I (R = Cl, R1 = NO2) were prepared similarly (R2, R3, R4, % yield, and m.p. given): OMe, H, H, 36, 108-9°; H, OMe, H, 25, 122-3°; H, H, OMe, 32, 99-100°; H, H, F, 20, 119-20°. Condensation of 0.02 mole 4,3-Cl(O2N)C6H3SO2NH2 (III) and 0.03 mole PhNH2 by fusing for 6 hrs. at 130° gave 71.8% I (R = NO2, R1 = SO2NH2, R2 = R3 = R4 = H), m. 179-80°. Other I (R = NO2, R1 = SO2NH2) were prepared similarly (R2, R3, R4, % yield, and m.p. given): Me, H, H, 84, 195-6°; H, Me, H, 85, 172-3°; H, H, Me, 90, 196-7°; OMe, H, H, 41, 225-6°; H, OMe, H, 91, 181-2°; H, H, OMe, 89, 226-7°; F, H, H, 61, 206-7°; H, F, H, 77, 195-6°; H, H, F, 80, 234-5°; Cl, H, H, 42, 202-3°; H, Cl, H, 80, 201-2°; H, H, Cl, 80, 241-2°; Br, H, H, 60, 200-1°; H, Br, H, 79, 207-8°; H, H, Br, 84, 235-6°; CF3, H, H, 40, 169-70°; H, CF3, H, 82, 210-11°; H, H, CF3, 29, 260-1°; H, H, SO2Me, 59, 253-4°. Condensation of 4.7 g. 2,5-Cl(O2N)C6H3SO2NH2 (IV) with 0.04 mole PhNH2 in 100 ml. boiling PhNO2 for 24 hrs. gave 68.4% I (R = SO2NH2, R1 = NO2, R2 = R3 = R4 = H), m. 175-6°. Other I (R = SO2NH2, R1 = NO2) were prepared similarly (R2, R3, R4, % yield, and m.p. given): OMe, H, H, 62, 205-8°; H, OMe, H, 59, 172-4°; H, H, OMe, 65, 160°; F, H, H, 60, 182-3°; H, F, H, 68, 173-4°; H, H, F, 71, 162-4°. A mixture of 25 g. 4,3-Cl(O2N)C6H3CO2H and 50 ml. SOCl2 was refluxed for 2 hrs., stripped of excess SOCl2, and treated with excess NH4OH to give 86.4% 4,3-Cl(O2N)C6H3CONH2, m. 154-5° (EtOH), which (0.02 mole) was condensed with 0.04 mole PhNH2 in EtOH containing NaOAc to give 34.4% I (R = NO2, R1 = CONH2, R2 = R3 = R4 = H), m. 194-5°. Other I were prepared similarly (R, R1, R2, R3, R4, % yield, and m.p. given): NO2, CONH2, OMe, H, H, 68, 144-5°; NO2, CONH2, H, OMe, H, 72, 170-1°; NO2, CONH2, H, H, OMe, 68, 220-1°; NO2, CONH2, F, H, H, 60, 169-71°; NO2, CONH2, H, F, H, 67, 191-2°; NO2, CONH2, H, H, F, 78, 207-8°; NO2, CONH2, H, H, SO2Me, 10, 244-5°; CONH2, NO2, H, H, H, 25, 184-5°; CONH2, NO2, OMe, H, H, 59, 215-16°; CONH2, NO2, H, OMe, H, 55, 198-9°; CONH2, NO2, H, H, OMe, 79, 216-17°; CONH2, NO2, F, H, H, 49, 184-5°; CONH2, NO2, H, F, H, 43, 233-4°; CONH2, NO2, H, H, F, 82, 231-2°; CONH2, NO2, H, H, SO2Me, 7, 207-8°. Esterification of 4,3-Cl(O2N)C6H3CO2H gave 4,3-Cl(O2N)C6H3CO2Et, m. 60-1° (EtOH), which was condensed with PhNH2 in boiling EtOH to give 92.8% I (R = NO2, R1 = CO2Et, R2 = R3 = R4 = H), m. 114-15°. Other I were prepared similarly (R, R1, R2, R3, R4, % yield, and m.p. given): NO2, CO2Et, OMe, H, H, 72, 116-18°; NO2, CO2Et, H, OMe, H, 70, 105-6°; NO2, CO2Et, H, H, OMe, 63, 128-9°; NO2, CO2Et, F, H, H, 15, 120-2°; NO2, CO2Et, H, F, H, 69, 79-80°; NO2, CO2Et, H, H, F, 52, 138-9°; NO2, CO2Et, H, H, SO2Me, 13, 149-50°; CO2Et, NO2, H, H, H, 29, 111-12°; CO2Et, NO2, OMe, H, H, 41, 112-13°; CO2Et, NO2, H, OMe, H, 46, 81-2°; CO2Et, NO2, H, H, OMe, 56, 120-2°; CO2Et, NO2, F, H, H, 18, 105°; CO2Et, NO2, H, F, H, 59, 119-20°; CO2Et, NO2, H, H, F, 34, 121-2°; CO2Et, NO2, H, H, SO2Me, 10, 189-90°; NO2, CF3, H, H, H, 63, 84°; NO2, CF3, OMe, H, H, 39, 123-4°; NO2, CF3, H, OMe, H, 81, 67-8°; NO2, CF3, H, H, OMe, 80, 85-6°; NO2, CF3, F, H, H, 76, 77-8°; NO2, CF3, H, F, H, 70, 93°; NO2, CF3, H, H, F, 54, 77-8°; NO2, CF3, H, H, SO2Me, 10, 149-50°. Nitration of p-ClC6H4SO2Me with KNO3 in concentrated H2SO4 at 80-5° for 3 hrs. gave 81.7% 4,3-Cl(O2N)C6H3SO2Me, m. 121-2° (20% aqueous alc.), which was condensed with PhNH2 to give 92% I (R = NO2, R1 = SO2Me, R2 = R3 = R4 = H), m. 130-1°. A solution of 15 g. 0-ClC6H4CN in fuming HNO3 was allowed to warm to room temperature from 0-4° in 1 hr., kept for 1 hr. at room temperature, and mixed with 600 ml. ice-water to give 81.8% 2,5-Cl(O2N)C6H3CN, m. 108° (EtOH), which was condensed with PhNH2 in the presence of NaOAc to give 78% I (R = CN, R1 = NO2, R2 = R3 = R4 = H), m. 159-60°. Similarly prepared was I (R = NO2, R1 = CN, R2 = R3 = R4 = H), m. 121-2°. A suspension of 21.7 g. 4,2-Br(O2N)C6H3NH2 in 85 ml. concentrated HCl at 0-4° was diazotized with NaNO2, stirred 1 hr. at 5°, mixed with 15 g. CuCl2 in 50 ml. concentrated HCl, warmed to 70° in 1 hr., and stirred for 30 min. at 70° and overnight at room temperature to give 50% 5,2-Br(Cl)C6H3NO2, m. 70-1° (20% aqueous alc.), which was condensed with PhNH2 to give 80.5% I (R = NO2, R1 = Br, R2 = R3 = R4 = H), m. 54-6°. Similarly prepared were I (R = Br, R1 = NO2, R2 = R3 = R4 = H), m. 111-12°. I (R = NO2, R1 = F, R2 = R3 = R4 = H), m. 120-1°, and I (R = F, R1 = NO2, R2 = R3 = R4 = H), m. 134°. Nitration of 4-ClC6H4CHO gave 80% 4,3-Cl(O2N)C6H3CHO, m. 65-6° (EtOH), which was condensed with PhNH2 in the presence of NaOAc to give a mixture of I (R = NO2, R1 = CHO, R2 = R3 = R4 = H), m. 147-8°, and 4,3-PhNH(O2N)C6H3CH:NPh, m. 108-9°. Similarly prepared was 2,5-PhNH(O2N)C6H3CHO, m. 182° (by-product and m. 132-3°). Attempted conversion of II with 2-, 3-, or 4-FC6H4NH2 or with 3-MeOC6H4NH2 in refluxing HCONMe2 gave 75-85% 2,4-Cl(O2N)C6H3NMe2, m. 78°. Similarly, III and 2- or 4-F3CC6H4NH2 in HCONMe2 gave 4,3-Me2N(O2N)C6H3SO2NH2, m. 133-4°, while IV with all arylamines in HCONMe2 gave 2,5-Me2N(O2N)C6H3SO2NH2, m. 147-8° (EtOH). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to diphenylamines disperse dye, dye diphenylamines disperse, disperse dye diphenylamines, dyes and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

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On August 1, 2007, Rachid, Zakaria; Katsoulas, Athanasia; Williams, Christopher; Larroque, Anne-Laure; McNamee, James; Jean-Claude, Bertrand J. published an article.Related Products of 34662-29-8 The title of the article was Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties. And the article contained the following:

Steps toward the identification of combi-mols. with strong abl tyrosine kinase (TK) inhibitory property and significant DNA damaging potential are described. The optimized combi-mol. (I) was shown to induce approx. twofold stronger abl TK inhibitory activity than Gleevec and high levels of DNA damage in chronic myelogenous leukemic cells. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Related Products of 34662-29-8

The Article related to gleevec analog preparation abl tyrosine kinase inhibitor antitumor leukemia, Pharmacology: Structure-Activity and other aspects.Related Products of 34662-29-8

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On December 14, 2006, Meyer, Adam Gerhard; Winzenberg, Kevin Norman; Sawutz, David G.; Riches, Andrew Geoffrey published a patent.Product Details of 34662-29-8 The title of the patent was Preparation of N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives as ecto- and endoparasiticides. And the patent contained the following:

The title derivatives I, II and III [R = H, alkyl, alkenyl, alkynyl, aralkyl;, etc.; R1-9 = H, CN, NO2, halo, etc.; X = O, S, SO, etc.] are prepared as ecto- and endoparasiticides. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Product Details of 34662-29-8

The Article related to phenyltrifluoromethanesulfonamide derivative preparation endoparasiticide ectoparasiticide, Agrochemical Bioregulators: Invertebrate and other aspects.Product Details of 34662-29-8

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On December 3, 2003, Suga, A.; Kubota, H.; Miura, M.; Sasuga, D.; Moritani, H. published a patent.SDS of cas: 34662-29-8 The title of the patent was Preparation of tetrahydropyranalkyl carboxamide derivatives as inhibitors of apo β-related lipoprotein secretion. And the patent contained the following:

A novel tetrahydropyran derivative which has an excellent apo B-related lipoprotein secretion-inhibiting activity of the following general formula (I) or a salt thereof are prepared wherein R1 and R3 are the same or different and each represents H or lower alkyl; R2 is H, halogen, Ra-lower alkyl, or R20O-CO-; Ra is H, R21O-CO-, R22R23N-, R24R25N-CO-, R26O-cyano, or optionally-substituted hetero ring; R4, R5, R6 and R7 are the same or different and each is H, halogen, haloalkyl, cyano, lower alkyl, lower alkyl-O-, R21O-CO-lower alkyl-, R27-CO-, or R28R29N-S(O)2-; R8 and R9 are the same or different and each is H, lower alkyl, R30-lower alkyl-, R31R32N-, optionally- substituted hetero ring, or R33R34R35C-; R8 and R9 may together form optionally-substituted hetero ring-; X is N or CR36; R20, R22 to R26, R28, R29, R32 and R36 are the same or different and each is H or lower alkyl; R21 is H, lower alkyl, or aryl-lower alkyl-; R27 is HO-, lower alkyl-O-, or optionally-substituted hetero ring-, or lower alkyl-O-; R30 represents optionally-substituted aryl, optionally-substituted hetero ring-, or lower alkyl-O-; R31 represents optionally-substituted aryl, or optionally-substituted hetero ring-; R33 represents HO-lower alkyl-, or optionally-substituted hetero ring-lower alkyl-; R34 represents optionally-substituted aryl-. Thus, e.g., II was prepared by hydrolysis of corresponding Et ester (preparation given). In assays to evaluate apo β-related lipoprotein secretion-inhibiting activity, selected compounds of I possessed IC50 values ranging from 1.7-40 nM. As inhibitors of apo β-related lipoprotein secretion, I have excellent blood cholesterol and triglyceride-lowering effect, and are useful as remedies for hyperlipemia, arteriosclerosis, obesity and pancreatitis. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).SDS of cas: 34662-29-8

The Article related to pyran tetrahydro derivative preparation lipoprotein secretion inhibitor, pyranalkylcarboxamide derivative preparation hyperlipemia arteriosclerosis obesity pancreatitis, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.SDS of cas: 34662-29-8

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Bertini, Simone; Saccomanni, Giuseppe; DelCarlo, Sara; Digiacomo, Maria; Gargini, Claudia; Piano, Ilaria; Campisi, Giuseppe Matteo; Ghidoni, Riccardo; Macchia, Marco; Manera, Clementina published an article in 2017, the title of the article was Application of an improved HPLC-FL method to screen serine palmitoyl transferase inhibitors.Product Details of 34662-29-8 And the article contains the following content:

In this work, we reported the application and validation of an improved high-performance liquid chromatog. method coupled with a fluorimetric detector (HPLC-FL) to screen the activity of two heterocyclic derivatives reported as serine palmitoyl transferase (SPT) inhibitors. The anal. conditions were optimized in terms of the derivatization procedure, chromatog. condition, extraction procedure, and method validation according to EMEA guidelines. Once fully optimized, the method was applied to assess the SPT-inhibitory activity of the above-mentioned derivatives and of the reference inhibitor myriocin. The obtained results, expressed as a percentage of residual SPT activity, were compared to those obtained with the reference radio immune assay (RIA). The good correlation between the two types of assay demonstrated that the improved HPLC-FL method is suitable for a preliminary and rapid screening of potential SPT-inhibitors. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Product Details of 34662-29-8

The Article related to serine palmitoyl transferase inhibitor hplcfl method, hplc, spt, enzymatic assay, screening, serine palmitoyl transferase, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Product Details of 34662-29-8

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On June 27, 2002, Li, Guiying; Peterson, John M.; Albaugh, Pamela; Currie, Kevin S.; Cai, Guolin; Gustavson, Linda M.; Lee, Kyungae; Hutchison, Alan; Singh, Vinod; Maynard, George D.; Yuan, Jun; Ling, Hong Xie; Ghosh, Manuka; Liu, Nian; Luke, George P.; Mitchell, Scott; Allen, Martin Patrick; Liras, Spiros published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Aryl or heteroaryl fused imidazoles as selective GABAA receptor ligands. And the patent contained the following:

Title compounds I [W = N or CR3, X = N or CR4, Y = N or CR5, Z = N or CR6 with the provision that no more than two of W, X, Y and Z are N; Q = O or CR7R8; R1 = H, haloalkyl, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, etc.; R2 = nitrogen containing 5-7 membered (un)substituted heteroaryl or heterocycloalkyl ring with up to 4 heteroatoms independently selected from N, S, and O; R3, R4, R5 and R6 are independently selected from H, halo, OH, NO2, CN, (un)substituted alkyl, alkoxy, etc.] and there pharmaceutically acceptable salts are prepared and disclosed as selective GABAA receptor ligands. Thus, II was prepared in five steps from malonyl dichloride and Et vinyl ether with imidazole ring formation via cyclocondensation of 3-amino-4-ethylaminobenzonitrile with 1-(3-fluorophenyl)-5-carboxymethylpyrazole. The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. Preferred compounds of the invention exhibit Ki values of < 100 nM for binding at the benzodiazepine site with more preferred compounds exhibiting Ki values of < 10 nM. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. This invention also relates to the use of I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Addnl. this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile

The Article related to imidazole aryl preparation gaba receptor ligand cns agent, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 10, 2010, Canne Bannen, Lynne; Chan, Diva Sze-Ming; Gu, Xiao-Hui; Mac, Morrison B.; Ng, Stephanie; Wang, Tie-Lin; Wang, Yong; Xu, Wei published a patent.Application of 34662-29-8 The title of the patent was Imidazo[1,2a]pyridine derivatives, their use as S1P1 agonists and methods for their production. And the patent contained the following:

The invention is directed to compounds of formula I as well as methods of making and using the compounds Compounds of formula I wherein R1 is H, halo, CN, C1-6 alkoxy, amino, etc.; R2 is H, Me, and MeO; R3 is H, C1-6 alkyl, C1-6 alkylsulfonyl, halo, C1-6 haloalkyl, etc.; R4 is H and C1-6 alkyl; A is 5-membered heteroarylene; R5 is (un)substituted Ph and (un)substituted heteroaryl; and stereoisomers, mixtures of isomers, and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their S1P1 agonistic activity. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to imidazopyridine preparation s1p1 agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 34662-29-8

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 31, 2002, Goker, Hakan; Kus, Canan; Boykin, David W.; Yildiz, Sulhiye; Altanlar, Nurten published an article.Formula: C7H3ClN2O2 The title of the article was Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species. And the article contained the following:

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids, ethyl-5-carboxylate, -5-carboxamides,-5-carboxaldehyde, -5-chloro-, -5-trifluoromethyl, and -5-carbonitriles, -6-carbonitrile were prepared and evaluated in vitro against Candida species. The cyano substituted compounds exhibited the greatest activity with MIC values of 3.12 μg/mL, values similar to that of fluconazole. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2

The Article related to substituted phenyl benzimidazole carbonitrile candida activity, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2

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