Category: 34662-24-3

Adding a certain compound to certain chemical reactions, such as: 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34662-24-3, COA of Formula: C7H3ClN2O2

A solution of anhydrous EtOH (20 mL) was bubbled through NH3 at 0C to obtain 7M NH3/EtOH. It was transfered intoa sealed tube containing 2-chloro-3-nitrobenzonitrile (0.5 g, 2.7 mmol, 1.0 eq). The mixture was allowed to warm to 18C gradually and then stirred at 110C for 12 hours. The mixture was evaporated under reduced pressure to remove the most solvent to give 0.5 g of crude 2- amino-3-nitrobenzonitrile as a yellow solid which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34662-24-3, Quality Control of 2-Chloro-3-nitrobenzonitrile

A solution of anhydrous EtOH (20 mL) was bubbled through NH3 at 0C to obtain 7M NH3/EtOH. It was transfered intoa sealed tube containing 2-chloro-3-nitrobenzonitrile (0.5 g, 2.7 mmol, 1.0 eq). The mixture was allowed to warm to 18C gradually and then stirred at 110C for 12 hours. The mixture was evaporated under reduced pressure to remove the most solvent to give 0.5 g of crude 2- amino-3-nitrobenzonitrile as a yellow solid which was used in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 34662-24-3, A common heterocyclic compound, 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, molecular formula is C7H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step c) intermediate 11Synthesis of 2-[(2-hydroxyethyl)amino]-3-nitrobenzonitrile2-chloro-3-nitrobenzonitrile (74g, 0.408 mol) is mixed with ethanol (370 ml) and ethanolamine (57 ml). The mixture is stirred for 16 hrs at room temperature. To complete the reaction, the mixture is refluxed for 2 hours. After cooling, the mixture is concentrated under vacuum; the product precipitates as a red solid. To eliminate the ethanolamine hydrochloride salt, the suspension is triturated with 500 ml of water and filtrated under vacuum. The solid is washed with ethanol and ether then dried to give the desired product (75g, 89%).IH NMR (300MHz, DMSO-d6) delta ppm 3.55-3.60 (m,2H) 3.69-3.74 (m,2H) 6.75 (dd, 7=7.63, 8.52 Hz, 2H) 7.90 (dd, /=7.63, 1.76 Hz, 2H) 8.27 (dd, /=8.52, 1.76 Hz, IH) 3.35 m, IH)

The synthetic route of 34662-24-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2008/18827; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 2-Chloro-3-nitrobenzonitrile

Example 1732- [4-(l-Benzofuran-5-yl)phenyl]-l-{[(3S)-l-(cyclopropylcarbonyl)-3- pyrrolidinyl] methyl}- lH-benzimidazole-7-carbonitrile(a) 2-({[(3S)-l-(Cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-3- nitrobenzonitrileA mixture of {[(3S)-l-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amine (553 mg, 3.29 mmol), 2-chloro-3 -nitrobenzonitrile (500 mg, 2.74 mmol), and DIEA (1.431 mL, 8.22 mmol) were dissolved in 1,4-dioxane (10 mL) in a microwave Vial. The mixture was heated at 150 C for 1 hour. The mixture was evaporated, taken up in DCM and washed with water. The aqueous layer was extracted with DCM and the combined organics evaporated and purified by silica gel column chromatography using a gradient of 0-5% MeOH/DCM to afford the titled compound (800 mg, 2.55 mmol, 93 % yield) as an orange solid. 1H NMR (400 MHz, chloroform-d) delta ppm 0.71-0.88 (m, 2 H) 0.94-1.12 (m, 2 H) 1.59-1.69 (m, 1 H) 1.69-2.00 (m, 1 H) 2.11-2.41 (m, 1 H) 2.55-2.92 (m, 0 H) 3.16-4.11 (m, 6 H) 6.80 (ddd, J=10.04, 8.40, 7.58 Hz, 1 H) 7.79 (ddd, J=9.35, 7.71, 1.39 Hz, 1 H) 8.27- 8.49 (m, 1 H) 8.53-8.80 (m, 1 H).

According to the analysis of related databases, 34662-24-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia; WO2011/56635; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chloro-3-nitrobenzonitrile

To a solution of 2-chloro-3-nitrobenzonitrile (200 mg, 1 .3 mmol) in absolute THF (20 mL) was added dropwise BH3SMe2 (0.2 mL, 2.6 mmol) under nitrogen atmosphere protection. The mixture was stirred at reflux for 2 hrs. Then 2 N HCI (1 .5 mL) was added to the mixture and the mixture was stirred at reflux for 1 hour. The mixture was condensed to crude compound CI-1 -5B (248 mg) as yellow solid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34662-24-3.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; HENDRICKSON, Thomas, Francis; HO, Koc-Kan; SAUNDERS, Michael, David; STEVENS, Brian, John; SWIERCZEK, Krzysztof; WRIGHT, Kevin, Bret; WO2013/62945; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34662-24-3, name is 2-Chloro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H3ClN2O2

2-Amino-4-cyano-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline A mixture of 4-amino-1-(3,3-diphenylpropyl)piperidine di-trifluoroacetate (Method I) (500 mg, 0.96 mmol), 2-chloro,3-nitrobenzonitrile (373 mg, 2.04 mmol) and potassium carbonate (700 mg, 5.05 mmol) in DMSO (4 ml) was heated at 90 C. After 15 h the mixture was poured onto water and extracted with EtOAc (2*30ml). The organics were combined, washed with brine, dried (MgSO4), concentrated and purified by Bond Elut chromatography to give 4-cyano-2-nitro-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline as an oil (300 mg, 0.68 mmol), MS: 442.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Burrows, Jeremy; Cumming, John; Mcinally, Thomas; US2003/119869; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts