Category: 3441-01-8

Reference of 3441-01-8,Some common heterocyclic compound, 3441-01-8, name is 3-Cyanobenzamide, molecular formula is C8H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 4.78 g of m-cyanobenzoic acid (yield 94percent, based on m-cyanobenzamide). The m-cyanobenzoic acid obtained had a purity of 98percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Cyanobenzamide, its application will become more common.

Reference:
Patent; Showa Denko Kabushiki Kaisha; US6433211; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

3441-01-8, name is 3-Cyanobenzamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: nitriles-buliding-blocks

To a vial were added methyl l-(4-bromophenyl)-3- hydroxycyclobutanecarboxylate (335.8 mg, 1.178 mmol), 3-cyanobenzamide (258 mg, 1.77 mmol), copper(I) iodide (40.4 mg, 0.212 mmol), (lS,2S)-Nl,N2-dimethylcyclohexane-l,2- diamine (80 mg, 0.56 mmol), K2CO3 (331 mg, 2.39 mmol) and dioxane (6 mL). The mixture was evacuated and backfilled with N2 for 4 times, then heated at 120 °C for 17 h. The mixture was diluted with water and EtOAc. After extraction, the combined organic layers were washed with brine, dried over Na2S04i filtered and concentrated in vacuo to afford a residue, which was purified by column chromatography on silica gel (EtOAc in hexane : 0-100percent gradient) to afford the title compound. MS (EI) m/z 373 [M+Na]+.

The synthetic route of 3441-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; SLOMAN, David, L.; YU, Wensheng; (98 pag.)WO2019/27855; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 3441-01-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3441-01-8, name is 3-Cyanobenzamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 20 Sodium nitrite (2.07 g) was dissolved in a 70 wt. percent aqueous sulfuric acid solution (100 ml), and m-cyanobenzamide (2.92 g) was added to the resultant solution. The mixture was allowed to react at 40° C. for one hour with stirring. The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 2.68 g of m-cyanobenzoic acid (yield 92percent). The m-cyanobenzoic acid obtained had a purity of 99percent or more.

The synthetic route of 3-Cyanobenzamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Showa Denko Kabushiki Kaisha; US6433211; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 3441-01-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3441-01-8 as follows.

To a stirred solution of 2-((6-bromopyridin-3-yl)(methoxy)methyl)-6- (trifluoromethyl)-3H-imidazo[4,5-b]pyridine (200 mg, 0.517 mmol) in THF (5 mL) were added 3-cyanobenzamide (113 mg, 0.775 mmol) and sodium 2-methylpropan-2-olate (99 mg, 1.0 mmol), Brettphos Pd G3 (47 mg, 0.052 mmol) at RT. After the addition was finished, the reaction was stirred at 60 °C for 16 h. The reaction was diluted with water, extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2S04i filtered and concentrated in vacuo to afford a residue, which was purified by reversed phase HPLC, eluting with water (0.1 percentTFA)-ACN to afford the title compound as a TF A salt (Ex. 39). XH NMR (400 MHz, CD3OD) delta 8.67 (s, 1 H), 8.52 (d, J=1.8 Hz, 1 H), 8.32 (t, J=1.4 Hz, 1 H), 8.28 – 8.24 (m, 3 H), 7.96-7.94 (m, 2 H), 7.74-7.72 (m, 1 H),5.77(s, 1 H), 3.54 (s, 3 H); MS (EI) m/z: 453 [M+H]+.

According to the analysis of related databases, 3441-01-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; FRADERA, Xavier; HAN, Yongxin; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; WHITE, Catherine; YU, Wensheng; (89 pag.)WO2019/27856; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 3441-01-8, These common heterocyclic compound, 3441-01-8, name is 3-Cyanobenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a vial equipp ed with a stir bar were added 2-(l-(5-bromopyridin-2- yl)cyclobutyl)-lH-benzo[d]imidazole (23.5 mg, 0.0720 mmol), cesium carbonate (70 mg, 0.22 mmol), 3-cyanobenzamide (10 mg, 0.070 mmol), (l S,2S)-Nl,N2-dimethylcyclohexane-l,2- diamine (2.0 mg, 0.014 mmol), and dioxane (358 muUpsilon . The vial was purged with nitrogen, and copper (I) iodide (1.36 mg, 7.16 muiotatauiotaomicron) was added. The vial was purged with nitrogen for 3 minutes, then the vial was sealed and heated to 110 °C for 16 h. After 16 h the mixture was diluted with DMSO, filtered, and purified by reversed phase HPLC, eluting with water (0.1 percentTF A)-ACN to afford the title compound as a TFA salt (Ex. 46). XH NMR (600 MHz,DMSO-c) delta 10.77 (s, 1H), 8.95 (s, 1H), 8.45 (s, 1H), 8.30 (dd, J = 13.1, 8.4 Hz, 2H), 8.14 (d, J = 7.6 Hz, 1H), 7.86 – 7.78 (m, 3H), 7.76 (d, J = 8.6 Hz, 1H), 7.59 – 7.54 (m, 2H), 3.25 – 2.80 (m, 4H), 2.21 – 2.08 (m, 2H). MS (EI) m/z 394 [M+H]+. Example 47: 3 -Chloro-N-(6-( 1 -(6-cvano- 1 H-benzo [dl imidazol-2-yl)cvclobuty l)pyridin-3 – vDbenzamide

Statistics shows that 3-Cyanobenzamide is playing an increasingly important role. we look forward to future research findings about 3441-01-8.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; FRADERA, Xavier; HAN, Yongxin; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; WHITE, Catherine; YU, Wensheng; (89 pag.)WO2019/27856; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

3441-01-8, name is 3-Cyanobenzamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H6N2O

To a vial were added 2-(3-(4-bromophenyl)oxetan-3-yl)-6-chloro-lH- benzo[d]imidazole (50 mg, 0.14 mmol), 3-cyanobenzamide (24.1 mg, 0.165 mmol), (1 S,2S)- N,N’-dimethylcyclohexane-l,2-diamine (7.8 mg, 0.055 mmol), copper(I) iodide (5.2 mg, 0.028 mmol), K2CO3 (44 mg, 0.32 mmol) and dioxane (700 mu). The mixture was evacuated and backfilled with N2 for 4 times, then heated at 120 °C for 17 h. The mixture was filtered and purified by reversed phase HPLC, eluting with water (0.1percentTFA)-ACN to afford the title compound as a TFA salt (Ex. 11). XH NMR (499 MHz, DMSO-c) delta 10.50 (s, 1H), 8.40 (s, 1H), 8.24 (d, J= 7.1 Hz, 1H), 8.07 (d, J = 6.8 Hz, 1H), 7.88 – 7.70 (m, 3H), 7.71 – 7.50 (m, 2H), 7.38 (d, J= 7.5 Hz, 2H), 7.27 (d, J = 7.9 Hz, 1H), 5.36 (d, J= 4.9 Hz, 2H), 5.15 (d, J = 5.0 Hz, 2H); MS (EI) m/z 429 [M+H]+.

The synthetic route of 3441-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; SLOMAN, David, L.; YU, Wensheng; (98 pag.)WO2019/27855; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 3441-01-8,Some common heterocyclic compound, 3441-01-8, name is 3-Cyanobenzamide, molecular formula is C8H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 4.78 g of m-cyanobenzoic acid (yield 94percent, based on m-cyanobenzamide). The m-cyanobenzoic acid obtained had a purity of 98percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Cyanobenzamide, its application will become more common.

Reference:
Patent; Showa Denko Kabushiki Kaisha; US6433211; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

3441-01-8, name is 3-Cyanobenzamide, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Cyanobenzamide

To a vial were added methyl l-(4-bromophenyl)-3- hydroxycyclobutanecarboxylate (335.8 mg, 1.178 mmol), 3-cyanobenzamide (258 mg, 1.77 mmol), copper(I) iodide (40.4 mg, 0.212 mmol), (lS,2S)-Nl,N2-dimethylcyclohexane-l,2- diamine (80 mg, 0.56 mmol), K2CO3 (331 mg, 2.39 mmol) and dioxane (6 mL). The mixture was evacuated and backfilled with N2 for 4 times, then heated at 120 °C for 17 h. The mixture was diluted with water and EtOAc. After extraction, the combined organic layers were washed with brine, dried over Na2S04i filtered and concentrated in vacuo to afford a residue, which was purified by column chromatography on silica gel (EtOAc in hexane : 0-100percent gradient) to afford the title compound. MS (EI) m/z 373 [M+Na]+.

The synthetic route of 3441-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ZHOU, Hua; ACHAB, Abdelghani; FRADERA, Xavier; HAN, Yongxin; LI, Derun; MCGOWAN, Meredeth, A.; SCIAMMETTA, Nunzio; SLOMAN, David, L.; YU, Wensheng; (98 pag.)WO2019/27855; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 3441-01-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3441-01-8, name is 3-Cyanobenzamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 27 A 70 wt. percent aqueous solution (100 ml) of sulfuric acid and m-cyanobenzamide (2.92 g) were placed in a 200-ml three-neck flask, and the resultant mixture was stirred. Subsequently, a 50 wt. percent solution (10 g) of nitrosylsulfuric acid, obtained through dissolution of nitrosylsulfuric acid (5 g) in sulfuric acid (5 g), was added dropwise to the mixture. When the addition was completed, the mixture was allowed to react at room temperature for 30 minutes. The precipitated crystals were collected, washed with water, and dried, to thereby obtain 2.68 g of m-cyanobenzoic acid (yield 92percent). The m-cyanobenzoic acid obtained had a purity of 98percent or more.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyanobenzamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Showa Denko Kabushiki Kaisha; US6433211; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3441-01-8, name is 3-Cyanobenzamide, A new synthetic method of this compound is introduced below., SDS of cas: 3441-01-8

Example 23 m-Cyanobenzamide (2.92 g), sodium nitrite (2.76 g), and dimethyl sulfoxide (50 ml) were mixed and stirred vigorously at room temperature. To the mixture, methanesulfonic acid (3.95 g) was added dropwise over ten minutes, and further stirred vigorously for three hours. The solvent was removed under reduced pressure, and water (50 ml) was added to the residue. The precipitated crystals were collected through filtration, washed with water, and dried, to thereby obtain 2.57 g of m-cyanobenzoic acid (yield 88percent). The obtained m-cyanobenzoic acid had a purity of 96percent.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Showa Denko Kabushiki Kaisha; US6433211; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts