Category: 34403-48-0

Electric Literature of 34403-48-0, The chemical industry reduces the impact on the environment during synthesis 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, I believe this compound will play a more active role in future production and life.

Et3N (35.96 ml, 256 mmol) was added to a solution of the amine (31.17 g, 213 mmol) in CH2Cl2 (150 ml). Benzyl chloroformate (36.37 ml, 256 mmol) in CH2Cl2 (50 ml) was then added dropwise at a temperature of 0 C. The reaction mixture was stirred overnight at RT and washed with aqueous 0.1 M HCl (150 ml) and H2O (150 ml), dried over Na2SO4 and filtered out, and the solvent was removed in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-((Methylamino)methyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gruenenthal GmbH; US2008/153843; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H10N2

To a solution of compound 222 (1 mmol), Aldehyde/ketone (1 mmol), in THF was added NaBH3CN (2 mmol). The reaction mixture was stirred at room temperature overnight. After disappearance of the starting material as indicated by TLC, a solution of saturated NH4C1 solution (5 mL) was added dropwise at room temperature. The mixture was then diluted with Et20 (30 mL) and washed three times with water (30 mL), and brine (30 mL). Organic layer was dried over Na2S04, concentrated under vacuum, and the residue was purified by column chromatography to provide compound 223.

The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; WANG, Hua; KHANFAR, Mohammad; WO2014/100833; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A round-bottom flask was charged with norbornane-2-carboxylic acid (1.0 g, 1 eq.) and thionyl chloride (O.95 g, 2 eq.) was added dropwise. The mixture was warmed to 70 C. for 1 hour. The mixture was cooled to room temperature and dichloromethane (20 mL) was added. Subsequently 4-(methylaminomethyl)benzonitrile (1.03 g, 1.1 eq) was added portion wise. The mixture was stirred at room temperature over night until HPLC indicated complete conversion. The organic layers were washed with hydrochloric acid (1 M), brine and dried over sodium sulfate. The solvent was removed under reduced pressure and the title compound was used directly without further purification.

The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; QUINTERO PALOMAR, Maria Angelica; CRAIG, Ian Robert; WIEBE, Christine; MENTZEL, Tobias; FEHR, Marcus; ESCRIBANO CUESTA, Ana; WINTER, Christian Harald; LOHMANN, Jan Klaas; MUELLER, Bernd; CAMBEIS, Erica; GROTE, Thomas; SEET, Michael; (36 pag.)US2020/45974; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 489 5-(chloromethyl)-6-phenylimidazo[1,5-a]pyridine 55b (25 mg, 0.103 mmol), 491 4-((methylamino)methyl)benzonitrile (29 mg, 0.2 mmol), 27 K2CO3 (69 mg, 0.5 mmol) and 149 acetonitrile (5 mL) were mixed at room temperature, heated to 55 C. and stirred for 18 h. After cooled to room temperature, the mixture was filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate=1/1 to 1/3) to give the target 492 product 4-((methyl((6-phenylimidazo[1,5-a]pyridin-5-yl)methyl)amino)methyl)benzonitrile 55 (25 mg, light yellow oil). Yield: 71%.MS m/z (ESI): 353[M+1]1H NMR (400 MHz, CDCl3) delta 8.64 (s, 1H), 7.64-7.42 (m, 7H), 7.38-7.22 (m, 4H), 6.70 (d, J=9.2 Hz, 1H), 3.89 (s, 2H), 3.44 (s, 2H), 2.11 (s, 3H).

The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Innocare Pharma Tech Co., Ltd.; CHEN, Xiangyang; GAO, Yingxiang; US2019/185472; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 34403-48-0, A common heterocyclic compound, 34403-48-0, name is 4-((Methylamino)methyl)benzonitrile, molecular formula is C9H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-(methylaminomethyl)benzonitrile (5.0 g, 1 eq.) and triethylamine (8.65g, 2.5 eq.) in dichloromethane (100 ml.) was added 2,2,2-trifluoroethanesulfonyl chloride (0520) (7.49 g, 1 .2 eq.). The mixture was stirred at room temperature for two hours. Then ethyl acetate was added, the organic layer was washed with water, dried over sodium sulfate and (0521) concentrated in vacuo to yield the title compound (10.4g) as yellow solid witch was used without further purification

The synthetic route of 34403-48-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; QUINTERO PALOMAR, Maria Angelica; CRAIG, Ian Robert; WIEBE, Christine; MENTZEL, Tobias; FEHR, Marcus; ESCRIBANO CUESTA, Ana; WINTER, Christian Harald; LOHMANN, Jan Klaas; MUELLER, Bernd; GROTE, Thomas; CAMBEIS, Erica; (62 pag.)WO2018/114393; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts