Category: 34133-58-9

Nakagawa, Masayuki published the artcilePhotonucleophilic reactions of nitrofen, Safety of 4-Hydroxyisophthalonitrile, the main research area is nitrofen photonucleophilic reaction; photolysis nitrofen.

Irradiation of nitrofen (I) [1836-75-5] in the presence of KCN formed 2,4-dichlorobenzonitrile [6574-98-7] and related compounds, whereas the photoreaction with piperidine formed p-nitrophenol [100-02-7] and tarry products from the addnl. reactions of the intermediate 2,4-dichlorophenol [120-83-2] with piperidine. 2,4-Dichlorophenol also reacted with KCN to form 2,4-dicyanophenol [34133-58-9]. These and other photonucleophilic reactions may help to explain the environmental dissipation of many pesticides.

Journal of Agricultural and Food Chemistry published new progress about Photolysis. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Safety of 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tsuhako, Amy Lew published the artcileThe design, synthesis, and biological evaluation of PIM kinase inhibitors, HPLC of Formula: 34133-58-9, the main research area is benzofuropyrimidinone preparation pim kinase inhibitor.

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitations. Using X-ray crystal structures of the bound PIM-1 complexes with I, II, and III, the authors were able to guide the SAR and identify alkyl benzofuropyrimidinone IV with good PIM potencies, permeability, and oral exposure.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, HPLC of Formula: 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mao, Qing published the artcileDesign, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors, Safety of 4-Hydroxyisophthalonitrile, the main research area is alkoxycyanophenyl oxodihydropyrimidine carboxylic acid preparation xanthine oxidase inhibitor SAR; acute toxicity docking hypouricemic alkoxycyanophenyl oxodihydropyrimidine carboxylic acid preparation; 1,6-Dihydropyrimidine-5-carboxylic acid; Biological evaluation; Synthesis; Xanthine oxidase inhibitor.

A series of 2-(4-alkoxy-3-cyano)phenyl-1,6-dihydropyrimidine-5-carboxylic acid derivatives I [R = O, NH; R1 = i-Pr, allyl, Bn, etc.; R2 = H, Me] was synthesized as novel xanthine oxidase (XO) inhibitors. These compounds exhibited remarkable in vitro XO inhibitory potency with IC50 values ranging from 0.0181 μM to 0.5677 μM. Specifically, compounds I [R = NH; R1 = (CH2)2CH(CH3)2, 2-methylallyl], with IC50 values of 0.0240 μM and 0.0181 μM, resp., emerged as the most potent XO inhibitors and their potencies were comparable to that of febuxostat. Structure-activity relationship anal. revealed that the Me group at 4-position of pyrimidine ring could damage the potency and the XO inhibitory potency was maintained when carbonyl group was changed to an imino group. Lineweaver-Burk plot anal. revealed that the representative compound I [R = NH; R1 = (CH2)2CH(CH3)2] acted as a mixed-type inhibitor. A potassium oxonate induced hyperuricemia model in rats was chosen to further confirm the hypouricemic effect of compound I [R = NH; R1 = (CH2)2CH(CH3)2] and the results showed that compound I [R = NH; R1 = (CH2)2CH(CH3)2] (5 mg/kg) was able to significantly lower the serum uric acid level. Furthermore, in acute oral toxicity study, no sign of toxicity was observed when the mice were administered with a single 2000 mg/kg oral dose of compound I [R = NH; R1 = (CH2)2CH(CH3)2]. These results suggested that compound I [R = NH; R1 = (CH2)2CH(CH3)2] was a potent and promising uric acid-lowing agent for the treatment of hyperuricemia.

European Journal of Medicinal Chemistry published new progress about Acute toxicity. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Safety of 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hatano, Kouta published the artcileSyntheses of 2,4-dicyanophenoxyacetic acid and its analogs, Category: nitriles-buliding-blocks, the main research area is cyanophenoxyacetate pesticide; phenoxyacetate cyano pesticide.

Cyanophenoxyacetic acids (I; R = H; R1 = H, CN; R2 = Me, H, CN) and their Et esters (I; R = Et) were prepared in order to test their pesticidal properties. E.g. Reimer-Tiemann reaction of o-HOC6H4CHO, followed by refluxing the resulting 2,4-(OHC)2C6H3OH with NH2OH.HCl in AcOH gave 2,4-(NC)2C6H3OH which reacted with BrCH2CO2Et to give I (R = Et, R1 = R2 = CN). The other I were prepared similarly.

Agricultural and Biological Chemistry published new progress about cyanophenoxyacetate pesticide; phenoxyacetate cyano pesticide. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nakagawa, Masayuki published the artcilePhotonucleophilic reactions of nitrofen, Safety of 4-Hydroxyisophthalonitrile, the main research area is nitrofen photonucleophilic reaction; photolysis nitrofen.

Irradiation of nitrofen (I) [1836-75-5] in the presence of KCN formed 2,4-dichlorobenzonitrile [6574-98-7] and related compounds, whereas the photoreaction with piperidine formed p-nitrophenol [100-02-7] and tarry products from the addnl. reactions of the intermediate 2,4-dichlorophenol [120-83-2] with piperidine. 2,4-Dichlorophenol also reacted with KCN to form 2,4-dicyanophenol [34133-58-9]. These and other photonucleophilic reactions may help to explain the environmental dissipation of many pesticides.

Journal of Agricultural and Food Chemistry published new progress about Photolysis. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Safety of 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gorvin, John H. published the artcileAromatic nitro-group displacement reactions. Part 4. The action of cyanide and halide ions on compounds containing strongly activated nitro groups, Computed Properties of 34133-58-9, the main research area is nitro group displacement reaction; cyanide reaction nitroarom compound; halide reaction nitroarom compound.

Routes for the reaction of cyanide or halide ions in dipolar aprotic solvents with aromatic compounds, e.g., 2-nitroisophthalonitrile, containing strongly activated nitro groups comprise (a) direct displacement of NO2, (b) ring-substitution coupled with hydroxydenitration and (c) (for CN-) fragmentation of NO2 without substitution.

Journal of Chemical Research, Synopses published new progress about Substitution reaction. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Computed Properties of 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Osman, Maged A. published the artcileNematogens for matrix-addressed twisted nematic displays. I, Safety of 4-Hydroxyisophthalonitrile, the main research area is liquid crystal twisted nematic display; electrooptical display liquid crystal; cyanophenyl ester liquid crystal display; fluorocyanophenylcyclohexane derivative liquid crystal; matrix addressed liquid crystal display.

Nematogens with small Δε/ε1 for matrix-addressed TN-displays were prepared The effect of introducing lateral cyano groups on the dielec. constants and the thermodn. stability of the mesophase of 4-cyanophenyl esters is described. Fluoro-4-trans-n-alkyl-4-cyanophenylcyclohexanes suitable for matrix addressing were prepared and the effect of the fluoro substituent on the clearing point was studied.

Molecular Crystals and Liquid Crystals published new progress about Electrooptical imaging devices. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Safety of 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sato, Takahiro published the artcileDesign, synthesis, and pharmacological and pharmacokinetic evaluation of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors, Recommanded Product: 4-Hydroxyisophthalonitrile, the main research area is phenylpyridinyltriazole derivative preparation xanthine oxidoreductase.

In an effort to find a potent xanthine oxidoreductase (XO) inhibitor, we discovered the best compound I. Here, we describe the following: (1) the design, synthesis, and structure-activity relationship of a series of 3-phenyl-5-pyridyl-1,2,4-triazole derivatives by in vitro studies of XO inhibitory activity in bovine milk and in vivo studies of serum uric acid (UA) reductive activity in rats, (2) a drug interaction study by a cytochrome P 450 3A4 (CYP3A4) assay, and (3) a pharmacokinetic (PK) study. Compound I exhibits potent XO inhibitory activity, serum UA-lowering activity in rats, weak CYP3A4 inhibitory activity, and moderate PK profile.

Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (xanthine oxidoreductase). 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Recommanded Product: 4-Hydroxyisophthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chapas, Richard B. published the artcileNef-type transformation in basic solution, HPLC of Formula: 34133-58-9, the main research area is Nef reaction nitro nitrile ketone; mechanism aromatic Nef reaction.

The replacement of the nitro group of o-O2NC6H4CN to give 2-hydroxyisophthalonitrile (I) (by the action of NaCN in Me2SO) occurred via a Nef-type reaction of the cyanide ion adduct of the nitro nitrile. The normal 2nd product of the Nef reaction, N2O was produced in yield comparable to that of I. P-O2NC6H4CN and p-O2NC6H4COPh reacted similarly. The mechanism was discussed.

Journal of Organic Chemistry published new progress about Nitro compounds Role: PRP (Properties). 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, HPLC of Formula: 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Smith, Cameron J. published the artcile2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety, Quality Control of 34133-58-9, the main research area is CETP inhibitor arylbenzoxazole preparation structure activity.

A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was beneficial for CETP inhibition. Compound 47 was the most potent inhibitor in this series and inhibited CETP with an IC50 of 28 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Quality Control of 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts