Category: 332-25-2

Related Products of 332-25-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 332-25-2 name is 4-(Trifluoromethoxy)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2:; To a stirred solution of N,N-diethyl-4-methoxy-2-methyl-benzamide (10.0 g, 45.2 mmol) in THF (150 mL) at -78° C. under nitrogen atmosphere was added t-BuLi (29.2 mL of 1.7M in pentane, 49.7 mmol) dropwise. The resulting red solution was kept at this temperature for additional 10 min before dropwise addition of 4-(trifluoromethoxy)-benzonitrile (9.49 g, 49.7 mmol). The brown solution was stirred at -78° C. for 2 h; tests by LCMS showed incomplete reaction. Thus to the mixture was added an additional amount of 4-(trifluoromethoxy)-benzonitrile (3.38 g, 18.1 mmol) and the resulting mixture was stirred for an additional 1 h. The mixture was then allowed to warm to rt and was quenched by pouring into aqueous 1.0M HCl (50 mL). EtOAc (100 mL) was added and the mixture was shaken and phases were separated. A precipitate occurred within the EtOAc phase which was isolated by filtration and allowed to dry (3.0 g). This 3.0 g of isolated solid was determined to be impure product and was set aside for later purification. The EtOAc filtrate was set aside. The aqueous acid washes were combined and extracted with DCM (3.x.100 mL). The DCM extracts were combined, washed with brine, dried over MgSO4, filtered and concentrated in vacuo. This residue was combined with the original EtOAc filtrate and the combined organics were concentrated to a slurry. A solid was isolated by filtration to give the desired product (8.84 g, 58.0percent yield). LC-MS, MS m/z 336 (M++H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Trifluoromethoxy)benzonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/119461; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 332-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Hydroxylamine hydrochloride (2.8 g, 40 mmol),Sodium carbonate (2.7 g, 26 mmol) was dissolved in water (33 mL)4-Trifluoromethoxybenzonitrile (3.0 g, 16 mmol) andEthanol (17 mL) and heated at reflux for 6 hours.After cooling to room temperature, it was extracted with ethyl acetate (2 x 100 mL)The organic layers were combined, washed with saturated NaCl,Anhydrous Na2SO4 dried,The solvent was recovered to give 3.1 g of white powder in 89percent yield;

The synthetic route of 4-(Trifluoromethoxy)benzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhejiang University; Sheng Rong; Hu Yongzhou; Cao Ji; Li Shan; Qiu Ni; Zhao Mengdan; Yang Bo; He Qiaojun; (33 pag.)CN106366078; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 332-25-2, The chemical industry reduces the impact on the environment during synthesis 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, I believe this compound will play a more active role in future production and life.

Step 5 N-Hydroxy-4-(trifluoromethoxy)benzimidamide [0365] To a solution of 4-(trifluoromethoxy)benzonitrile (2.0 g, 10.6 mmol) in EtOH (20 mL), TEA (53 g, 53.0 mmol) and NH2OH.HCl (3.6 g, 26.5 mmol) were added in sequence. The mixture was refluxed for 4 h, cooled to RT, and concentrated under reduced pressure. The residue was diluted with H2O (20 mL), and extracted with EtOAc (20 mL×3). The combined organic layers were washed with H2O (1×10 mL) and brine (1×10 mL), dried over Na2SO4, filtered and concentrated to afford the crude N-hydroxy-4-(trifluoromethoxy)benzimidamide (2.0 g, 85percent), which was directly used for next reaction without further purification. MS (ES+) C8H7F3N2O2 requires: 220. found: 221 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Institute For Applied Cancer Science/The University of Texas MD Anderson Cancer Center; Jones, Philip; DiFrancesco, Maria Emilia; Petrocchi, Alessia; Marszalek, Joe; Liu, Gang; US2014/57914; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 4-(Trifluoromethoxy)benzonitrile

A solution of lithium aluminium hydride in diethyl ether (1.0M, 69.4 ml) was added dropwise to a stirred solution of 4-(trifluoromethoxy)benzonitrile (6.0 g) in diethyl ether (120 ml) over 15 minutes. Water (2.66 ml), 10percent sodium hydroxide solution (2.66 ml) and water (7.98 ml) were then added successively, dropwise. The precipitated solid was filtered off and washed with diethyl ether. The filtrate and washings were combined and evaporated under reduced pressure to give 4-(trifluoromethoxy)benzyl alcohol, N.M.R. in deuteriochloroform: delta2.3 (1H,s), 4.65 (2H,s), 7.2 (2H,d), 7.35 (2H,d).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Imperial Chemical Industries PLC; US5006543; (1991); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 332-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

4-Trifluoromethoxybenzaldehyde Diisobutylaluminium hydride (11.8 ml. 1M solution in toluene) was added to a stirred solution of 4-cyanophenyl trifluoromethyl ether (2.0 g., Fairfield) in dry diethyl ether (100 ml.). The mixture was refluxed with stirring for 3 hours. The mixture was cooled and dioxane (5 ml.) containing water 1.0 ml.) was added. Dilute hydrochloric acid was added (60 ml. of 10percent solution). The mixture was stirred for 30 minutes and extracted with diethyl ether. The ethereal extracts were washed with water and dried over anhydrous magnesium sulphate. The solvent was removed in vacuo and the residue was purified by chromatography on silica, eluding with 9:1 hexane:diethyl ether. 4-Trifluoromethoxybenzaldehyde was obtained as a colourless liquid (1.65 g.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The Wellcome Foundation; The Regents of the University of California; US5502073; (1996); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 332-25-2,Some common heterocyclic compound, 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, molecular formula is C8H4F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the same manner as in Reference Example 1, the title compound was obtained. Melting point: 222-225¡ã C. NMR (CDCl3( delta: 5.19(2H,s), 5.92(2H,s), 7.25-7.45(5H,m), 7.73(1H,d,J=8.8 Hz), 8.46 (1H,s). Elemental analysis for C20H11F3O5 Calcd: C, 61.86percent; H, 2.86percent Found: C, 64.79percent; H, 2.79percent

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethoxy)benzonitrile, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6340704; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 332-25-2

The 4 – trifluoro nitrile (187 mg, 1mmol), butyric aldehyde wo (96 mg, 1 . 1mmol), [Cp * IrCl2]2(8 mg, 0 . 01mmol, 1 muM percent), toluene (1 ml) are added to the 25 ml Schlenk reaction bottle. The mixture 100 ¡ãC reaction under 6 hours, cooling to room temperature. The benzyl alcohol (140 mg, 1 . 3mmol) and cesium carbonate (65 mg, 0.2 equiv.) is added to the bottle in the reaction, the mixture 130 ¡ãC then continue to react under 12 hours, cooling to room temperature. The solvent is removed by rotary evaporation, then through the column chromatography (developing solvent: ethyl acetate/petroleum ether) to obtain the pure target compound, yield: 82percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 332-25-2.

Reference:
Patent; Nanjing University of Science and Technology; Li Feng; Wang Nana; Zou Xiaoyuan; (15 pag.)CN105016938; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

332-25-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, A new synthetic method of this compound is introduced below.

Step A: Anhydrous CeCl3 (0.84 g, 3.4 mmol) was stirred in dry THF (10 mL), at room temperature, under a N2 atmosphere for 2 h. Then, the solution was cooled at -78 ¡ãC, followed by dropwise addition of MeLi (2.2 mL, 3.4 mmol, 1.6 M), and allowed to stir for 30 min at -78 ¡ãC. Then, a solution of 4-methoxybenzonitrile (0.15 g, 1.1 mmol) in dry THF (5 mL) was added dropwise to the above solution. The crude reaction was stirred at room temperature overnight, quenched by adding 1.5 mL of concentrated NH4OH, and allowed to stir for 1 h at room temperature. The organic layer was filtered, dried over anhydrous Na2SO4, and concentrated in vacuo. The crude product was used for next reaction without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Gallardo-Macias, Ricardo; Kumar, Pradeep; Jaskowski, Mark; Richmann, Todd; Shrestha, Riju; Russo, Riccardo; Singleton, Eric; Zimmerman, Matthew D.; Ho, Hsin Pin; Dartois, Veronique; Connell, Nancy; Alland, David; Freundlich, Joel S.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 601 – 606;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts