Related Products of 330793-38-9,Some common heterocyclic compound, 330793-38-9, name is 4-Bromo-2-methoxybenzonitrile, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of 5.349g (lOOmmol) of ammonium chloride in 200mL of toluene was dropped lOOmL (lOOmmol) of IM-triethylaluminum/hexane, and the mixture was stirred for 1.5 hours at room temperature. Then, to this mixture was added 8.48g (40mmol) of the compound obtained in the Manufacturing Example 2, and the mixture was stirred for 24 hours at 80°. After the reaction mixture was cooled with ice water, 30g of silica gel and 300mL of chloroform were added to the mixture and the mixture was stirred for 30 minutes under the roomtemperature. The mixture was filtrated with Celite.(R). and the residue was washed with 400mL of methanol. The organic layer was concentrated and 200mL of chloroform/methanol (9/1) solution was added to the residue. The mixture was filtrated and the filtrate was concentrated and the residue was washed sequentially with ether to give 3.47g (33percent) of the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-methoxybenzonitrile, its application will become more common.