Category: 32703-80-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32703-80-3, name is 4-(tert-Butyl)phthalonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Example 7 Z1XXX (tBu)10.0 parts of 4-tert-butylphthalonitrile (manufactured by Tokyo Chemical Industry Co., Ltd.) and 84 parts of methanol were mixed. A mixture of 8.15 parts of a 28% sodium methoxide methanol solution (manufactured by Wako Pure Chemical Industries, Ltd.) and 73 parts of methanol was added dropwise to the resulting mixture while keeping the temperature at 5 for 1 hour. The resulting mixture was stirred at 5 to 20 for 2 days.5.42 parts of acetic acid and 6.14 parts of ethyl cyanoacetate (manufactured by Tokyo Chemical Industry Co., Ltd.) were added to the resulting mixture at 10 to 20 . The obtained mixture was stirred at 65 for 3 days.To the resulting mixture was added 2.69 parts of acetic acid and 3.07 parts of ethyl cyanoacetate (manufactured by Tokyo Chemical Industry Co., Ltd.), followed by stirring at 65 C for 3 days. To the obtained mixture, 5.36 parts of acetic acid, 7.25 parts of barbituric acid (manufactured by Tokyo Chemical Industry Co., Ltd.) and 363 parts of water were added, and the mixture was stirred at 65 C for 9 days.The obtained mixture was subjected to solvent distillation using a rotary evaporator, and the obtained residue was purified by column chromatography to obtain a mixture of a compound represented by the formula IZ1-20 and a compound represented by the formula IZ1-21.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Seumittomo Gaga Kku Gabu Siki Ga I Sya; O Da-ga-cheu-na-ri; Do Ga-i-ma-na-bu; Ha Ma-ki-hi-ro-hu-mi; (366 pag.)KR2018/26347; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32703-80-3, name is 4-(tert-Butyl)phthalonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C12H12N2

A reaction vessel was charged with f-butylphthalonitrile (0.5 g, 2.7 mmol), Di-(4- methylbenzoate)-fumaronitrile (0.31 g, 0.9 mmol), anhydrous pentan-1-ol (10 ml) and Diaza(1 ,3)bicyclo[5.4.0]undecane (DBU) (0.07 g, 0.5 mmol) under inert conditions. The contents of the reaction vessel were then heated to reflux for approximately 20 hours. The solvent was removed under reduced pressure to yield a blue/green residue which was placed on alumina and eluted with petroleum spirit ; ethyl acetate (85 : 1 ) to yield a dark blue solid.

According to the analysis of related databases, 32703-80-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CORUS UK LIMITED; HOLLIMAN, Peter; RUGEN-HANKEY, Sarah; WO2010/136178; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32703-80-3, name is 4-(tert-Butyl)phthalonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-(tert-Butyl)phthalonitrile

A mixture of 3.0 g (16.3 mmol) of 4-tert-butylphthalonitrile and 0.12 g (17.1 mmol) of lithium in 20 mL of anhydrous quinoline was re uxed for 3 h. The mixture was cooled, 30 mL of concentrated aqueous HCl and 150 mL of water were added with stirring, and the precipitate was ltered off, washed with water, and dried. The product was dissolved in chloroform and subjected to chromatography on aluminum oxide (activity grade III). The eluate was evaporated, and compound 1 was precipitated with methanol. Yield 0.8 g (36.2%), R f 0.52 (CHCl 3 -hexane, 3 : 1). Electronic absorption spectrum (CHCl 3 ), lambda max , nm (log epsilon): 342 (4.81), 603 (4.41), 645 (4.59), 664 (5.03), 701 (5.10). 1 H NMR spectrum (CDCl 3 ), delta, ppm: 2.60 br.s (2H, NH), 1.90 m (36H, t-Bu), 8.15 m (4H, 5-H), 8.86 m (4H, 3-H), 9.16 m (4H, 6-H). Mass spectrum (MALDI-TOF): m/z 739.156 [M] + .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 32703-80-3.

Reference:
Article; Dmitrieva, O. A.; Ivanova, Yu. B.; Khrushkova, Yu. V.; Lyubimova, T. V.; Mamardashvili, N. Zh.; Semeikin, A. S.; Russian Journal of General Chemistry; vol. 90; 5; (2020); p. 852 – 857; Zh. Obshch. Khim.; vol. 90; 5; (2020); p. 760 – 766,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32703-80-3, name is 4-(tert-Butyl)phthalonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-(tert-Butyl)phthalonitrile

4-(4-Methoxycarbonylphenyl)phthalonitrile (0.15 g, 0.5 mmol) and /-butyl phthalonitrile (0.26g, 1.4 mmol) were placed in a reaction vessel under inert conditions. Pentanol (20 ml_) and DBU (0.1mL) were added thereto and the contents of the reaction vessel heated to approximately 136 C for approximately 24 hours. The solvent was removed under reduced pressure and to yield a solid, which was placed on to alumina and eluted with ethyl acetate; petroleum spirit (70 : 40) to yield a dark green residue.

According to the analysis of related databases, 32703-80-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CORUS UK LIMITED; HOLLIMAN, Peter; RUGEN-HANKEY, Sarah; WO2010/136178; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts