Category: 32446-66-5

Electric Literature of 32446-66-5, The chemical industry reduces the impact on the environment during synthesis 32446-66-5, name is 4,4′-Dicyanobenzophenone, I believe this compound will play a more active role in future production and life.

EXAMPLE 2; PREPARATION OF 4,4′-(HYDROXY METHYLENE)BISBENZONITRILE OF FORMULA IV 200 ml of methanol was taken into a round bottom flask followed by charging 40 g of 4,4-dicyanobenzophenone and stirring for about 10 minutes. 3.28 g of sodium borohydride was added slowly to the above suspension at 0-5 C. followed by stirring at 25-30 C. for 30 minutes, and the formed solution was neutralized with 25 ml of glacial acetic acid to a pH of 6.33. 800 ml of water was charged to the above-neutralized suspension and stirred for 30 minutes, and the precipitate was filtered, washed with 400 ml of water and finally subjected to drying at 55-60 C. under vacuum for 4 hours to afford 40 g of title compound having a purity by HPLC of 99.36% and a water content by the Karl Fischer method of 0.27%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,4′-Dicyanobenzophenone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Palle, Venkata Raghavendra Acharyulu; Kalaria, Ashok Jerambhai; Shelke, Sandip Ashok; US2007/100149; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 32446-66-5,Some common heterocyclic compound, 32446-66-5, name is 4,4′-Dicyanobenzophenone, molecular formula is C15H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound III-2 (3.51 g, 8 mmol) was dissolved in 50 mL of dry THF and stirred.Cooled to -20 C in a nitrogen atmosphere,Then, 1.6 M of n-BuLi n-hexane solution (5 mL, 8 mmol) was slowly added dropwise with a syringe, and after the addition was completed,The reaction mixture was stirred at this temperature for an additional 1 hour.A solution of V-2 (1.86 g, 8 mmol) dissolved in 5 mL of dry THF was slowly added dropwise with a syringe.After the dropwise addition was completed, the reaction mixture was stirred at the same temperature for half an hour, and then warmed to room temperature and stirred for 1 hour.Finally, it was stirred under reflux overnight. The reaction mixture was carefully poured into 300 mL of ice water and stirred.The extract was extracted with 50 mL of EtOAc (3 mL).The desiccant was removed by suction filtration, and the filtrate was evaporated to dryness on a rotary evaporator.Compound VI-2 is obtained

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,4′-Dicyanobenzophenone, its application will become more common.

Reference:
Patent; Tianjin Xiaoxin Pharmaceutical Technology Co., Ltd.; Zeng Huaxian; (7 pag.)CN108129370; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 32446-66-5, The chemical industry reduces the impact on the environment during synthesis 32446-66-5, name is 4,4′-Dicyanobenzophenone, I believe this compound will play a more active role in future production and life.

EXAMPLE 2; PREPARATION OF 4,4′-(HYDROXY METHYLENE)BISBENZONITRILE OF FORMULA IV 200 ml of methanol was taken into a round bottom flask followed by charging 40 g of 4,4-dicyanobenzophenone and stirring for about 10 minutes. 3.28 g of sodium borohydride was added slowly to the above suspension at 0-5 C. followed by stirring at 25-30 C. for 30 minutes, and the formed solution was neutralized with 25 ml of glacial acetic acid to a pH of 6.33. 800 ml of water was charged to the above-neutralized suspension and stirred for 30 minutes, and the precipitate was filtered, washed with 400 ml of water and finally subjected to drying at 55-60 C. under vacuum for 4 hours to afford 40 g of title compound having a purity by HPLC of 99.36% and a water content by the Karl Fischer method of 0.27%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,4′-Dicyanobenzophenone, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Palle, Venkata Raghavendra Acharyulu; Kalaria, Ashok Jerambhai; Shelke, Sandip Ashok; US2007/100149; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 32446-66-5,Some common heterocyclic compound, 32446-66-5, name is 4,4′-Dicyanobenzophenone, molecular formula is C15H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-[(4-Cyanophenyl)methanehydrazonoyl]benzonitrile (8u). To a mixture of 4-[(4- eyanophenyl)earbonyl]benzonitrile (6u) (0.56 g, 2.4 mmol) and EtOH (30 ml) hydrazine monohydrate (1.8 g, 36 mmol) was added dropwise over 5 mm. The yellow solution wasstirred overnight (about 16 h) at 80C, the mixture was allowed to cool to rt and EtOAe (150 ml) was added. The organic layer was washed with water (50 ml + 2 x 25 ml). The inorganic wash layers were extracted with EtOAe (2 x 25 ml). The organic layers were combined, washed neutral with aq. sat. NaC1 (25 ml), dried over Na2SO4 and concentrated at reduced pressure to afford a slightly red solid 8u (0.51 g, 86%).

The synthetic route of 32446-66-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALLOCYTE PHARMACEUTICALS AG; BREITENSTEIN, Werner; HUERZELER, Marianne; KELLY, Terence; MANCUSO, Riccardo; SCHNEIDER, Gisbert; WEITZ-SCHMIDT, Gabriele; WO2015/189265; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 32446-66-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 32446-66-5, name is 4,4′-Dicyanobenzophenone, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 3 4-[alpha-(4-Cyanophenyl)-alpha-hydroxy-5-thiazolylmethyl]-benzonitrile Analogously to Example 1, the title compound is prepared starting from 0.512 ml of diisopropylamine, 2.44 ml of a 1.6M n-butyllithium solution, 530 mg of 2trimethylsilylthiazole and 603 mg of 4,4′-dicyanobenzophenone in THF at -70 and with working up in the same manner. Purification of column chromatography (SiO2, hexane/ethyl acetate 2:2) yields the title compound in pure for. TLC (hexane/ethyl acetate 2:2) Rf =0.2; 1 H-NMR (CDCl3): delta(ppm)=4.39 (s,1H), 7.42 (d,1H), 7.54 and 7.7 (m,8H), 7.88 (d,1H).

The chemical industry reduces the impact on the environment during synthesis 4,4′-Dicyanobenzophenone. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32446-66-5, name is 4,4′-Dicyanobenzophenone, A new synthetic method of this compound is introduced below., Computed Properties of C15H8N2O

123.4 g (388 mmol) 2,2′-Dibromo-biphenyl were dissolved in 450 ml dry THF and cooled to -78 C. 135 ml (323 mmol, 2.5 M in Hexane) n-BuLi was added slowly and the mixture was stirred for 45 min. 4,4′- Dicyanobenzophenone (CAS: 32446-66-5) was dissolved in 400 ml dry THF and cooled to -78 C. The mixture of n-Buli and 2,2′-Dibromo-biphenyl was then transferred to the 4,4′-Dicyanobenzophenonesolution. The reaction was warmed to room temperature over night and after that quenched with water. THF was evaporated in vacuo and the residue was extracted with ethyl acetate and water. The organic phase was dried, filtered and the solvent was removed in vacuo which resulted in 170 g of crude solid. The crude solid was refluxed over night with 2700 ml acetic acid and 200 ml (37%) hydrochloric acid. After cooling to RT the reaction mixture was poured in water and the resulting solid was filtered off, dissolved in (0168) dichloromethane, the solution was washed with water and NaHCO3, the organic phase was dried and the solvent removed in vacuo. The resulting solid was recrystallized in ethyl acetate and finally purified via flash chromatography. The resulting white solid 11 was obtained with a yield of 61 % (88 g , 197 mmol).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.