Category: 3218-50-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3218-50-6, name is 2,5-Dichlorobenzyl cyanide, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

To a suspension of NaH (60% w/w suspension in paraffin oil) (14.19 g, 354.76 mmol) in dimethyl sulfoxide (300 mL), was added (2,5-dichloro-phenyl)-acetonitrile (197) (30 g, 161.256 mmol) and 1,4-dibromobutane (19.34 mL, 161.26 mmol) by dissolving in dimethyl sulfoxide-ether (1:1, 600 mL) dropwise at 0 C. The reaction mixture was stirred at room temperature for 1 h. Silica thin layer chromatography was conducted (10% ethyl acetate in hexane, Rf=0.8). After completion of the reaction, water (500 mL) and 10% HCl solution (200 mL) were added and the mixture was extracted with ethyl acetate. The organic part was dried, and evaporated to get a crude residue, which was purified with silica gel (normal, 100-200 mesh) column chromatography using a gradient eluent of 2 to 10% ethyl acetate in hexane to get pure ( 198) (26.5 g, 68.44%) as a white solid. [0803] GCMS: 239 (M).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3218-50-6.

Reference:
Patent; Wolkerstorfer, Andrea; Szolar, Oliver; Handler, Norbert; Buschmann, Helmut; Cusack, Stephen; Smith, Mark; So, Sung-Sau; Hawley, Ronald Charles; Sidduri, Achyutharao; Zhang, Zhuming; US2014/194431; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 3218-50-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3218-50-6, name is 2,5-Dichlorobenzyl cyanide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2,5-dichlorobenzyl bromide (5.4 g, 22.5 mmol) in 16 mL of ethanol and potassium cyanide (1.63 g, 25 mmol) in 4 mL of water was heated at 80 C overnight, then cooled, and the solids were filtered and washed with ethanol to give 3.5 g of 2,5- dichlorophenylacetonitrile as a white powder melting at 89-91 C. The nitrile was suspended in 20 mL of ethanol, and 20 mL of a 25 % aqueous NaOH solution was added.The mixture was heated in a CEM Explore microwave reactor at 140 0C for 30 minutes, then cooled, poured into ice water and acidified to pH 1 with concentrated HCl to give a precipitate. The precipitate was filtered, washed with water and dried in a vacuum oven at90 0C for 5 h to give the title compound as a white powder. 1H NMR (CDCl3) 5 3.79 (s, 2H), 7.2-7.4 (m, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichlorobenzyl cyanide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2008/91594; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3218-50-6, name is 2,5-Dichlorobenzyl cyanide, A new synthetic method of this compound is introduced below., COA of Formula: C8H5Cl2N

To a stirred solution of 2-(2,5-dichlorophenyl)acetonitrile (700 mg, 3.76 mmol, 1.00 equiv) in water (6 mL) was added sulfuric acid (8 mL) dropwise. The resulting solution was stirred for 3 h at 110 C in an oil bath, diluted with H20 (100 mL), extracted with dichloromethane (3×50 mL) and the combined organic layers washed with brine (3×100 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide 700 mg (91%) of the product as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ARDELYX, INC.; LEWIS, Jason, G.; REICH, Nicholas; CHEN, Tao; JACOBS, Jeffrey W.; CHARMOT, Dominique; NAVRE, Marc; FINN, Patricia; CARRERAS, Christopher; SPENCER, Andrew; WO2013/96771; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

3218-50-6, Adding a certain compound to certain chemical reactions, such as: 3218-50-6, name is 2,5-Dichlorobenzyl cyanide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3218-50-6.

EXAMPLE 3 Preparation of 2-[1l-[(2,5-dichlorophenyl)acetyl]-4-piperidinyl]-N-methyl-N-[(1R)-1-phenylpropyl]-4-thiazolecarboxamide (Compound 110) Step A: Preparation of 2,5-dichlorobenzeneacetic acid. A mixture of 2,5-dichlorobenzyl bromide (5.4 g, 22.5 mmol) in 16 mL of ethanol and potassium cyanide (1.63 g, 25 mmol) in 4 mL of water was heated at 80 0C overnight, then cooled, and the solids were filtered and washed with ethanol to give 3.5 g of 2,5- dichlorophenylacetonitrile as a white powder melting at 89-91 C. The nitrile was suspended in 20 mL of ethanol, and 20 mL of a 25 % aqueous NaOH solution was added. The mixture was heated in a CEM Explore microwave reactor at 140 0C for 30 minutes, then cooled, poured into ice water and acidified to pH 1 with concentrated HCl to give a precipitate. The precipitate was filtered, washed with water and dried in a vacuum oven at 90 0C for 5 h to give the title compound as a white powder. 1H NMR (CDCl3) delta 3.79 (s, 2H), 7.2-7.4 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dichlorobenzyl cyanide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2007/14290; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts