Category: 3218-45-9

Zhang, Di et al. published their research in Chemosphere in 2019 | CAS: 3218-45-9

2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Product Details of 3218-45-9

Trace determination and occurrence of eight chlorophenylacetonitriles: An emerging class of aromatic nitrogenous disinfection byproducts in drinking water was written by Zhang, Di;Bond, Tom;Krasner, Stuart W.;Chu, Wenhai;Pan, Yang;Xu, Bin;Yin, Daqiang. And the article was included in Chemosphere in 2019.Product Details of 3218-45-9 This article mentions the following:

Two chlorophenylacetonitriles (CPANs) (2-chloro- and 3,4-dichlorophenylacetonitrile), representatives of an emerging class of aromatic nitrogenous disinfection byproducts, were recently identified in chlor(am)inated drinking water with liquid/liquid extraction and gas chromatog./mass spectrometry (GC/MS). Due to their high cytotoxicity, they are potentially significant drinking water contaminants. The detection limit for these two CPANs with the previous method was 100 ng L-1. To search for addnl. CPAN isomers, a more sensitive method for the simultaneous determination of eight CPANs was developed using solid-phase extraction (SPE)-GC/MS. GC/MS parameters and SPE pre-concentration conditions, including SPE cartridge, eluent type, eluent volume, and sample pH, were optimized. Under optimized conditions, the new method had method detection limits, method quantification limits, and precision ranging from 0.15 to 0.37 ng L-1, 0.50-0.95 ng L-1, and 5.8%-11%, resp. The recoveries of the eight CPANs ranged from 92% to 102%. The concentrations of the eight CPANs in nine finished drinking waters were determined to be at concentrations ranging from 0.5 to 155 ng L-1. Seven CPANs were detectable in all samples. CPANs were detected at concentrations between 0.8 and 155 ng L-1 in chlorinated waters, and from 0.5 to 15 ng L-1 in chloraminated waters. Across all waters, the sum of all CPANs in chloraminated waters was 13% of that in chlorinated systems. In the experiment, the researchers used many compounds, for example, 2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9Product Details of 3218-45-9).

2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Product Details of 3218-45-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 3218-45-9

The chemical industry reduces the impact on the environment during synthesis 2-(2,3-Dichlorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Related Products of 3218-45-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3218-45-9, name is 2-(2,3-Dichlorophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows.

(i) 2,,3-Dichlorophenylacetic acid Concentrated hydrochloric acid (100ml) was poured onto crushed ice (150ml), the solution added to 2,3-dichlorophenylacetonitrile (30.6gms), and the mixture refluxed for 3 hours. After cooling, the mixture was diluted with water (500ml), extracted with EtOAc (600ml) and the organic phase washed with brine before drying over MgSO4. Evaporation of the solvent left a white solid, 31.3gms.

The chemical industry reduces the impact on the environment during synthesis 2-(2,3-Dichlorophenyl)acetonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Patent; THE WELLCOME FOUNDATION LIMITED; EP459819; (1991); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Share a compound : 3218-45-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2,3-Dichlorophenyl)acetonitrile, and friends who are interested can also refer to it.

Electric Literature of 3218-45-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3218-45-9 name is 2-(2,3-Dichlorophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 2,3-dichiorophenyiacetonitriie {45 kg, 241 .9 mole) in methanol litres) was charged 30% w/w sodium methoxide in methanol solution ( 1 13.5 kg, 630.6 mole) then ethyifluoroacetate (29.7 kg, 280.1 mole). The reaction mixture was stirred overni¡ãhi and the product was precipitated from aqueous hydrochloric acid (63.7 kg, 648 mole) in water (350 litres). The slurry was filtered and the solid was dissolved in ethyl acetate and washed with brine solution. Ethyl acetate (100 litres) was removed by vacuum distillation. DMF (70 litres) was added and the distillation continued to remove the remaining ethyl acetate.To the resulting enol in DMF was added potassium carbonate (20 kg. 145 mole) over a period of 10 minutes. Aikyiation of the potassium enoiale was achieved using ethyl iodide (37.7kg, 24^ .9 mole) at 70’C for VA hours. The reaction mixture was partitioned between toluene (140 litres) and water (75 litres) and the toluene chase was washed with water (50 litres). Toluene (75 iitres) was removed by distillation to afford the crude product as a toluene solution.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2,3-Dichlorophenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/93587; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts