Category: 31938-07-5

In 2007,Aly, Youssef L.; Pedersen, Erik B.; La Colla, Paolo; Loddo, Roberta published 《Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group》.Archiv der Pharmazie (Weinheim, Germany) published the findings.SDS of cas: 31938-07-5 The information in the text is summarized as follows:

Synthesis and antiviral activities are reported of a series of 6-(3-alkynyl benzyl)-substituted analogs of MKC-442 (6-benzyl-1-(ethoxymethyl)-5-isopropyluracil), a highly potent agent against HIV. The 3-alkynyl group is assumed to give a better stacking of the substituted benzyl group to reverse transcriptase (RT) and this was believed to improve antiviral activity against HIV-1. The bromo derivatives, 5-alkyl-6-(3-bromo-benzyl)-1-ethoxymethyl derivatives 7a, b and 5-alkyl-6-(3-bromobenzyl)-1-allyloxymethyl derivatives 9a, b, showed activity against HIV on the same level as their corresponding analogs 10a-d with a 3-trimethylsilylalkynylbenzyl substituent and their desilylated analogs 11a-d. However, they all showed activity against HIV-1 wild type in the range of more than 10fold lower than the one of MKC-442. Moderate activity against Y181C and Y181C + K103N mutated strains was also observed and, in some cases, they were marginally better than those found for MKC-442. A few amino-DABO and S-DABO analogs were also synthesized but they were found to be inactive against HIV. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5

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In 2014,Fuchibe, Kohei; Mayumi, Yuka; Yokota, Misaki; Aihara, Hiromichi; Ichikawa, Junji published 《Indium(III)-catalyzed cationic cyclization of 1,1-difluoroallenes: regioselective synthesis of 1-fluoronaphthalenes》.Bulletin of the Chemical Society of Japan published the findings.Computed Properties of C8H6BrN The information in the text is summarized as follows:

1,1-Difluoroallenes underwent InBr3-catalyzed ring construction via in situ-generated allylic CF2 cations to give 1-fluoronaphthalenes in good yield. DFT calculations suggested that a pos. charge was localized on the CF2 carbon in the key allylic CF2 cation, which was stabilized by α-cation stabilizing effect of the fluorines and hyperconjugation with the adjuscent C-In σ bond.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Computed Properties of C8H6BrN) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Computed Properties of C8H6BrN

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《Exploration of highly efficient blue-violet light conversion agents for an agricultural film based on structure optimization of triphenylacrylonitrile》 was written by Wang, Yongtao; Yu, Yongjiang; Liu, Wenjing; Ren, Litong; Ge, Guixian. Category: nitriles-buliding-blocksThis research focused ontriarylacrylonitrile agricultural doping film light conversion; acrylonitrile derivatives; fluorescence; light conversion agents; light conversion film; photosynthesis. The article conveys some information:

To obtain highly efficient blue-violet light conversion agents used for an agricultural film, six triarylacrylonitrile derivatives and their doping films were prepared Further, the luminogens have the ability to convert UV light into blue-violet light and exhibit aggregation-dependent fluorescence emission and high-contrast fluorescence quantum yields from 0.004 to 0.833. On the basis of X-ray single-crystal diffraction anal. and aggregation-induced emission activity tests, the variant fluorescence quantum yields are attributed to intermol. π-π stacking and phase transition between the crystalline state and amorphous state. In a simulated greenhouse environment, the luminogens exhibit excellent photostability. However, their fluorescence intensity drops to 17-40% of the prime intensity after outdoor radiation for 1 mo as a result of the ring-closing oxidation reaction (in the summer). By comprehensively considering the above photophys. properties and mech. properties of the doping film, 2-([1,1′-biphenyl]-4-yl)-3,3-diphenylacrylonitrile is a potential light conversion agent for an agricultural film in the winter. More importantly, the results indicate that the properties of the light conversion films are expected to be further improved by mol. design, inhibiting the ring-closing oxidation reaction and dispersion of crystalline nanoparticles in the doping film. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Category: nitriles-buliding-blocks

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In 2018,Shen, Peng-Xiang; Hu, Liang; Shao, Qian; Hong, Kai; Yu, Jin-Quan published 《Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids》.Journal of the American Chemical Society published the findings.HPLC of Formula: 31938-07-5 The information in the text is summarized as follows:

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5HPLC of Formula: 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.HPLC of Formula: 31938-07-5

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Category: nitriles-buliding-blocksIn 2010 ,《New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Gommermann, Nina; Buehlmayer, Peter; von Matt, Anette; Breitenstein, Werner; Masuya, Keiichi; Pirard, Bernard; Furet, Pascal; Cowan-Jacob, Sandra W.; Weckbecker, Gisbert. The article conveys some information:

A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymic, cellular, and in vivo potency. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Category: nitriles-buliding-blocks

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Dahatonde, Dipak J.; Ghosh, Aritra; Batra, Sanjay published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Metal-Free Synthesis of Alkenylazaarenes and 2-Aminoquinolines through Base-Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols》.Electric Literature of C8H6BrN The article contains the following contents:

A metal-free, base-mediated, and atom-efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcs.) with Me azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2-aminoquinolines, resp. was described. CsOH. H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction proceeded with KOH as well. The protocol that worked efficiently in the presence of air was amenable over broad range of substrates. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Electric Literature of C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Electric Literature of C8H6BrN

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In 2006,Balskus, Emily P.; Jacobsen, Eric N. published 《α,β-Unsaturated β-silyl imide substrates for catalytic, enantioselective conjugate additions: A total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor》.Journal of the American Chemical Society published the findings.Name: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

Chiral (salen)Al μ-oxo dimer catalyzes the highly enantioselective conjugate addition of carbon-centered nucleophiles to α,β-unsaturated silyl imides. Allyldimethylsilane-substituted imide I was identified as an optimal substrate, undergoing addition reactions with a variety of nitrile nucleophiles in high yield and enantiomeric excess. The silicon-containing products are synthetically useful chiral building blocks, as demonstrated by their application to an enantioselective total synthesis of the potent proteasome inhibitor (+)-lactacystin. Elaboration of lactam II to the natural product was effected in 12 steps and in 11% overall yield and proceeded through an unusual spiro β-lactone intermediate. This compound was found to inhibit the chymotrypsin-like site of the 26S proteasome at similar levels to known inhibitor clasto-lactacystin β-lactone (omuralide). In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Name: 2-(3-Bromophenyl)acetonitrile)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Name: 2-(3-Bromophenyl)acetonitrile

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In 2018,Kavala, Veerababurao; Yang, Zonghan; Konala, Ashok; Yang, Tang-Hao; Kuo, Chun-Wei; Ruan, Jian-Yao; Yao, Ching-Fa published 《Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction》.European Journal of Organic Chemistry published the findings.Related Products of 31938-07-5 The information in the text is summarized as follows:

A one-pot reaction has been developed for the preparation of 1,2,3-fused indole polyheterocycles, e.g., I, by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C-C and three C-N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Related Products of 31938-07-5

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《Enantioselective Aryl-Iodide-Catalyzed Wagner-Meerwein Rearrangements》 was written by Sharma, Hayden A.; Mennie, Katrina M.; Kwan, Eugene E.; Jacobsen, Eric N.. Product Details of 31938-07-5 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

We report a strategy for effecting catalytic, enantioselective carbocationic rearrangements through the intermediacy of alkyl iodanes as stereodefined carbocation equivalent Asym. Wagner-Meerwein rearrangements of β-substituted styrenes are catalyzed by the C2-sym. aryl iodide 1 to provide access to enantioenriched 1,3-difluorinated mols. possessing interesting and well-defined conformational properties. Hammett and kinetic isotope effect studies, in combination with computational investigations, reveal that two different mechanisms are operative in these rearrangement reactions, with the pathway depending on the identity of the migrating group. In reactions involving alkyl-group migration, intermol. fluoride attack is product- and enantio-determining In contrast, reactions in which aryl rearrangement occurs proceed through an enantiodetermining intramol. 1,2-migration prior to fluorination. The fact that both pathways are promoted by the same chiral aryl iodide catalyst with high enantioselectivity provides a compelling illustration of generality across reaction mechanisms in asym. catalysis. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Product Details of 31938-07-5

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In 2011,de Koning, Pieter D.; Murtagh, Lorraine; Lawson, Jon P.; Vonder Embse, Richard A.; Kunda, Sastry A.; Kong, Wei published 《Development an efficient route to the 5-lipoxygenase inhibitor PF-04191834》.Organic Process Research & Development published the findings.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

A convergent six-step process for the synthesis of PF-04191834 (I), a potent and selective 5-lipoxygenase inhibitor, has been developed and used to deliver over 20 kg of API. The process uses the same bond-forming steps as the initial medicinal chem. route, including the use of two consecutive Pd-catalyzed Ar-S couplings to form the key diaryl thioether linkage. The reaction conditions and downstream processing have been optimized to eliminate column chromatog. and aqueous work-ups and to minimize disproportionation of I, to ensure successful scale-up. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application In Synthesis of 2-(3-Bromophenyl)acetonitrile)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts