Category: 31938-07-5

In 2014,Mahtab, Reena; Srivastava, Ashish; Gupta, Nishi; Kushwaha, Sandeep Kumar; Tripathi, Aradhna published 《Synthesis of novel 2-benzylbenzo[d] thiazole-6-sulfonamide derivatives as potential anti inflammatory agent》.Journal of Chemical and Pharmaceutical Sciences published the findings.Formula: C8H6BrN The information in the text is summarized as follows:

The benzothiazole derivatives such as substituted 2-benzylbenzo[d]thiazole-6-sulfonamides I [R = H, 2-HO, 2-MeO, 3-Br] were synthesized by using sulfa drugs from substituted benzyl bromides. All the newly synthesized benzothiazole derivatives showed considerable anti-inflammatory activity. The chem. structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectral and elemental anal. These compounds were screened for anti-inflammatory activity by carrageenan induced paw edema method in rats at a dose of 100 mg/kg body weight Among the tested compounds of benzothiazole derivatives, compounds I [R = 2-OH, 2-OMe, 2,5-(F)2, 4-Br] exhibited some anti-inflammatory activity but compounds I [R = H, 2-F, 4-F, 4-Cl, 3-Br] were more potent when compared to standard drug celecoxib. The experimental part of the paper was very detailed, including the reaction process of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Formula: C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Formula: C8H6BrN

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In 2017,Schischko, Alexandra; Ren, Hongjun; Kaplaneris, Nikolaos; Ackermann, Lutz published 《Bioorthogonal Diversification of Peptides through Selective Ruthenium(II)-Catalyzed C-H Activation》.Angewandte Chemie, International Edition published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

Methods for the chemoselective modification of amino acids and peptides are powerful techniques in biomol. chem. Among other applications, they enable the total synthesis of artificial peptides. In recent years, significant momentum has been gained by exploiting palladium-catalyzed cross-coupling for peptide modification. Despite major advances, the prefunctionalization elements on the coupling partners translate into undesired byproduct formation and lengthy synthetic operations. In sharp contrast, we herein illustrate the unprecedented use of versatile ruthenium(II)carboxylate catalysis for the step-economical late-stage diversification of α- and β-amino acids, as well as peptides, through chemo-selective C-H arylation under racemization-free reaction conditions. The ligand-accelerated C-H activation strategy proved water-tolerant and set the stage for direct fluorescence labeling as well as various modes of peptide ligation with excellent levels of positional selectivity in a bioorthogonal fashion. The synthetic utility of our approach is further demonstrated by twofold C-H arylations for the complexity-increasing assembly of artificial peptides within a multicatalytic C-H activation manifold. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Synthetic Route of C8H6BrN

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In 2017,Mi, Rui-Jie; Sun, Jing; Kuhn, Fritz E.; Zhou, Ming-Dong; Xu, Zhaoqing published 《A meta-selective-C-H alkenylation of phenol-derivatives employing a traceless organosilicon template》.Chemical Communications (Cambridge, United Kingdom) published the findings.Electric Literature of C8H6BrN The information in the text is summarized as follows:

A traceless O-benzeneacetonitrile silyl template-directed meta-selective-C-H Heck alkenylation of phenols was realized with good yields and high selectivities. Etherification of phenol with 3-cyanomethylphenylsilyl substituents gives the directing template, 3-R2C(CN)C6H4SiiPr2OC6H4R1 (R1 = Me, MeO, halo, CF3, MeO2C), which undergoes meta-regioselective palladium-catalyzed Heck alkenylation with Et acrylate, giving cinnamates 3-R2C(CN)C6H4SiiPr2OC6H3R1-3-CH:CHCO2Et; the latter can be easily deprotected, leaving hydroxycinnamates 3-HOC6H3R1CH:CHCO2Et. The template was readily removable through F–promoted O-Si cleavage under extremely mild conditions or recyclable through a p-TSA catalyzed process. The product was successfully applied in the preparation of a series of meta-alkenylated aromatic compounds In the experiment, the researchers used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Electric Literature of C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Electric Literature of C8H6BrN

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Nitrile – Wikipedia,
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In 2007,Paillet-Loilier, Magalie; Fabis, Frederic; Lepailleur, Alban; Bureau, Ronan; Butt-Gueulle, Sabrina; Dauphin, Francois; Lesnard, Aurelien; Delarue, Catherine; Vaudry, Hubert; Rault, Sylvain published 《Novel aminoethylbiphenyls as 5-HT7 receptor ligands》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:

The synthesis of a series of aminoethylbiphenyls, e.g., I, as novel 5-HT7 receptor ligands is described. The novel derivatives exhibit high affinity for the 5-HT7 receptor with selectivity toward 5-HT1A receptor. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Product Details of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2014,Mentese, Emre; Bektas, Hakan; Uelker, Serdar; Bekircan, Olcay; Kahveci, Bahittin published 《Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity》.Journal of Enzyme Inhibition and Medicinal Chemistry published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:

A practical protocol was used for the synthesis of benzimidazoles. The reaction of Et phenylacetimidate hydrochlorides with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. The corresponding ester and hydrazide derivatives were synthesized subsequently under microwave irradiation with good yields. All compounds were evaluated with regard to pancreatic lipase activity and benzimidazoles I (R = H, R1 = Br; R = Br, R1 = H) and II (R = H, CH2CO2Me) showed lipase inhibition at various concentrations2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Product Details of 31938-07-5

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 2-(3-Bromophenyl)acetonitrileIn 2021 ,《Pure room temperature phosphorescence emission of an organic host-guest doped system with a quantum efficiency of 64%》 appeared in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. The author of the article were Liu, Xiaoqing; Dai, Wenbo; Qian, Junjie; Lei, Yunxiang; Liu, Miaochang; Cai, Zhengxu; Huang, Xiaobo; Wu, Huayue; Dong, Yuping. The article conveys some information:

A new doped system with pure phosphorescent emission is constructed using four 1-(4-(diphenylamino)phenyl)-2-phenylethan-1-one derivatives containing halogen atoms as the guests and benzophenone as the host. That is, the doped system has only phosphorescence emission while almost no fluorescence emission and the phosphorescence quantum efficiency reaches up to 64%. Moreover, the ISC efficiency of excitons can be adjusted by changing the excitation wavelength, so the doped materials can selectively emit green phosphorescence or cyan fluorescence.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 2-(3-Bromophenyl)acetonitrile) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Recommanded Product: 2-(3-Bromophenyl)acetonitrile

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2015,Kahveci, Bahittin; Yilmaz, Fatih; Mentese, Emre; Ulker, Serdar published 《Microwave-assisted synthesis of some new coumarin derivatives including 1,2,4-triazol-3-one and investigation of their biological activities》.Chemistry of Heterocyclic Compounds (New York, NY, United States) published the findings.Recommanded Product: 31938-07-5 The information in the text is summarized as follows:

By using the microwave technol., a new protocol has been developed for the synthesis of new coumarin derivatives I [ R1 = H, Br; R = Me, 4-Cl-C6H4-CH2-, 4-Br-C6H4-CH2-, etc.] including 1,2,4-triazol-3-one skeleton. This protocol proves to be efficient and environmentally friendly in terms of easy work-up and good yields. All newly synthesized compounds were screened for their antimicrobial activity and lipase inhibition. Most of the compounds were found to be effective on Escherichia coli. Compounds I [R1 = Br, R = 2-Br-C6H4-CH2-; R1 = Br, R2 = 3,4-dichlorobenzyl] had a good effect on lipase inhibition. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Recommanded Product: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts