Category: 31938-07-5

In 2015,Chen, Jinju; Liu, Chuanxiang; Guan, Fengjie; Zhang, Chuanxiu; Ji, Kai; Wang, Xinyu; Xu, Min; Wu, Fanhong published 《Derivatives of α,α-Aryl Naphthalimide Nitriles as Fluoride Ion Sensors: Convenient Precursors for the Synthesis of Aryl Naphthalimide Ketones》.Synlett published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

A facile and efficient SnAr procedure involving the displacement of activated naphthalimide bromides with the anions of substituted aryl acetonitriles was developed for the preparation of α,α-aryl naphthalimide nitrile derivatives, which can be used as fluoride ion sensors and convenient precursors for the synthesis of aryl naphthalimide ketones based on fluoride-induced deprotonation followed by autoxidative decyanation. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Synthetic Route of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Synthesis included an article by Greve, Eric; Porter, Jacob D.; Dockendorff, Chris. Computed Properties of C8H6BrN. The article was titled 《DFT-Assisted Design and Evaluation of Bifunctional Amine/Pyridine-Oxazoline Metal Catalysts for Additions of Ketones to Unactivated Alkenes and Alkynes》. The information in the text is summarized as follows:

Bifunctional catalyst systems for the direct addition of ketones to unactivated alkenes/alkynes were designed and modeled by d. functional theory (DFT). The designed catalysts possess bidentate ligands suitable for binding of pi-acidic Group 10 metals capable of activating alkenes/alkynes, and a tethered organocatalyst amine to activate the ketone via formation of a nucleophilic enamine intermediate. The structures of the designed catalysts before and after C-C bond formation were optimized using DFT, and reaction steps involving Group 10 metals were predicted to be significantly exergonic. A novel oxazoline precatalyst with a tethered amine separated by a meta-substituted benzene spacer was synthesized via a 10-step sequence that includes a key regioselective epoxide ring-opening step. It was combined with Group 10 metal salts, including cationic Pd(II) and Pt(II), and screened for the direct addition of ketones to several alkenes and an internal alkyne. 1H NMR studies suggest that catalyst-catalyst interactions with this system via amine-metal coordination may preclude the desired addition reactions. The catalyst design approach disclosed here, and the promising calculations obtained with square planar Group 10 metals, light a path for the discovery of novel bifunctional catalysts for C-C bond formation. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Computed Properties of C8H6BrN) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Computed Properties of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nie, Hanyu; Sun, Li; Zhang, Mengge; Song, Chuanjun published an article in 2022. The article was titled 《TfOH-promoted cyclocondensation reaction of 2-arylacetonitriles》, and you may find the article in Tetrahedron.Name: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

Treatment of 2-arylacetonitriles with triflic acid under solvent-free conditions resulted in the formation of cyclodimeric 3-aminoisoquinolines, cyclotrimeric N-(isoquinolin-3-yl)amidines or triazines, resp., depending on the electronic nature of the aryl ring. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Name: 2-(3-Bromophenyl)acetonitrile)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Name: 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2014,Wu, Hai-Qiu; Pannecouque, Christophe; Yan, Zi-Hong; Chen, Wen-Xue; He, Qiu-Qin; Chen, Fen-Er; Balzarini, Jan; Daelemans, Dirk; De Clercq, Erik published 《Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase》.MedChemComm published the findings.Computed Properties of C8H6BrN The information in the text is summarized as follows:

A series of conformationally restricted dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) hybrids, e.g., I, which combined the structural features of C6-α-methylbenzyl-thio-DABOs (α-methyl-S-DABOs) and C6-α-cyanobenzyl-thio-DABOs (CN-S-DABOs), has been synthesized and biol. evaluated for their anti-HIV activity against wild-type HIV-1 strain IIIB, double RT mutant (K103N + Y181C) strain RES056 and HIV-2 strain ROD in MT-4 cell cultures. Most of these compounds exhibited inhibitory activity (wild-type) within the range of EC50 values from micromolar to nanomolar. Among them, compound I displayed the highest anti-HIV-1 activity with an EC50 value of 91 nM and a selectivity index (SI) of 548, which was more potent than zalcitabine and comparable to nevirapine and delavirdine in the same assay. The preliminary structure-activity relationship (SAR) and mol. docking anal. of this new series of conformationally constrained CN-S-DABO hybrids were also investigated. In the experiment, the researchers used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Computed Properties of C8H6BrN)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Computed Properties of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2015,Sugiura, Y.; Tachikawa, Y.; Nagasawa, Y.; Tada, N.; Itoh, A. published 《Synthesis of benzoyl cyanide through aerobic photooxidation of benzyl cyanide using carbon tetrabromide as a catalyst》.RSC Advances published the findings.Related Products of 31938-07-5 The information in the text is summarized as follows:

A synthetic method towards benzoyl cyanide through aerobic photooxidation of benzyl cyanide in the presence of carbon tetrabromide under visible light irradiation with fluorescent lamps have been developed. The experimental part of the paper was very detailed, including the reaction process of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Related Products of 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Monophosphine Ligands Promote Pd-Catalyzed C-S Cross-Coupling Reactions at Room Temperature with Soluble Bases》 were Xu, Jessica; Liu, Richard Y.; Yeung, Charles S.; Buchwald, Stephen L.. And the article was published in ACS Catalysis in 2019. Safety of 2-(3-Bromophenyl)acetonitrile The author mentioned the following in the article:

The Pd-catalyzed cross-coupling of thiols with aromatic electrophiles is a reliable method for the synthesis of aryl thioethers, which are important compounds for pharmaceutical and agricultural applications. Since thiols and thiolates strongly bind late transition metals, previous research has focused on catalysts supported by chelating, bisphosphine ligands, which were considered less likely to be displaced during the course of the reaction. We show that, by using monophosphine ligands instead, more effective catalysis can be achieved. Notably, compared to previous methods, this increased reactivity allows for the use of much lower reaction temperature, soluble bases, and base-sensitive substrates. In contrast to conventional wisdom, our mechanistic data suggest that the extent of displacement of phosphine ligands by thiols is, first, not correlated with the ligand bulk or thiol nucleophilicity and, second, not predictive of the effectiveness of a given ligand in combination with palladium. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Safety of 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2016,Hayashi, Shun; Yamazoe, Seiji; Koyasu, Kiichirou; Tsukuda, Tatsuya published 《Application of group V polyoxometalate as an efficient base catalyst: a case study of decaniobate clusters》.RSC Advances published the findings.Electric Literature of C8H6BrN The information in the text is summarized as follows:

The base catalytic activity of the decaniobate cluster (TMA)6[Nb10O28]·6H2O (TMA+ = tetramethylammonium cation) was studied theor. and exptl. D. functional theory calculations showed that the oxygen atoms in the cluster are highly neg. charged and suggested the possibility that the cluster can act as a base catalyst. We demonstrated for the first time that [Nb10O28]6- actually exhibits base catalytic activity for aldol-type condensation reactions including Knoevenagel and Claisen-Schmidt condensation reactions. The catalytic reactions proceeded under ambient conditions, suggesting that [Nb10O28]6- holds promise as a practical strong base catalyst.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Electric Literature of C8H6BrN) was used in this study.

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Electric Literature of C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Phenanthrene Synthesis by Palladium(II)-Catalyzed γ-C(sp2)-H Arylation, Cyclization, and Migration Tandem Reaction》 were Gou, Bo-Bo; Yang, Hui; Sun, Huai-Ri; Chen, Jie; Wu, Junliang; Zhou, Ling. And the article was published in Organic Letters in 2019. SDS of cas: 31938-07-5 The author mentioned the following in the article:

Phenanthrene is an important structural motif in chem. and materials science, and many synthetic routes have been developed to construct its skeleton. However, synthesis of unsym. phenanthrenes remains a challenge. Here, an efficient one-pot tandem reaction for the preparation of phenanthrenes via sequential γ-C(sp2)-H arylation, cationic cyclization, dehydration, and 1,2-migration was developed. A wide range of sym. and unsym. phenanthrenes with diversified functional groups were synthesized with good to excellent yields. In the experiment, the researchers used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.SDS of cas: 31938-07-5

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sallio, Romain; Payard, Pierre-Adrien; Pakulski, Pawel; Diachenko, Iryna; Fabre, Indira; Berteina-Raboin, Sabine; Colas, Cyril; Ciofini, Ilaria; Grimaud, Laurence; Gillaizeau, Isabelle published their research in RSC Advances in 2021. The article was titled 《Copper-catalyzed transformation of alkyl nitriles to N-arylacetamide using diaryliodonium salts》.Recommanded Product: 2-(3-Bromophenyl)acetonitrile The article contains the following contents:

This work reports a simple and efficient method for the copper-catalyzed redox-neutral transformation of alkyl nitriles e.g., PhCH(Me)CN using eco-friendly diaryliodonium salts as diphenyliodonium triflate, (4-bromophenyl)(2,4,6-trimethylphenyl)iodonium triflate, 2-thienyl-(phenyl)iodonium triflate, etc. and leading to N-arylacetamides e.g., PhCH(Me)C(O)NHPh. The method features high efficiency, broad substrate scope and good functional group tolerance. In addition to this study using 2-(3-Bromophenyl)acetonitrile, there are many other studies that have used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 2-(3-Bromophenyl)acetonitrile) was used in this study.

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Recommanded Product: 2-(3-Bromophenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2013,Li, Meiling; Woods, Philip A.; Smith, Martin D. published 《Cation-directed enantioselective synthesis of quaternary-substituted indolenines》.Chemical Science published the findings.Formula: C8H6BrN The information in the text is summarized as follows:

An asym. method for the synthesis of quaternary-substituted indolenines via a 5-endo-dig cyclization of an α-cyanocarbanion onto an isonitrile was developed. This transformation relies on Broensted acid activation of the isonitrile functional group under asym. phase transfer conditions in the presence of a Broensted base. Good to excellent levels of enantioselectivity were obtained (85 : 15 to 96 : 4 e r., 18 examples) using a bespoke bifunctional catalyst. Enantioenriched indolenines produced in this process can be intercepted by nucleophilic species with high levels of diastereoselectivity to generate complex indoline frameworks. This process offers a general asym. approach to reactions involving the isonitrile functional group. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Formula: C8H6BrN)

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Formula: C8H6BrN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts