Related Products of 31603-77-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31603-77-7, name is 4-Biphenylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-([1,1′-biphenyl]-4-yl) acetonitrile I (e.g. Sigma-Aldrich, catalogue no.133612, CAS no. 31603-77-7) (100 g, 517.46 mmol) in ethylene glycol (1000 mL), a solution of potassium hydroxide (590 g, 10515 mmol) in water (1000 mL) was added and the resulting mixture was heated to 120 C and stirred for 16h. The reaction mixture was cooled to 0 C and acidified with concentrated HCI with stirring. The solid separated out wascollected by filtration, washed with water and dried. The solid was dissolved in ethyl acetate and the ethyl acetate layer was washed with water, dried over sodium sulfate and concentrated under reduced pressure to get white solid. The solid was taken in petroleum ether, stirred for -30 mm, filtered and dried to get 2-([i,i-biphenyl]-4-yl)acetic acid 2 as white solid. (107.2 g, 97.6%).1H-NMR (400 MHz, DMSO-d6): 3 12.41 (br. s, 1 H), 7.59-7.66 (m, 4 H), 7.44-7.47 (m, 2 H);7.34-7.37 (m, 3 H), 3.61 (5, 2 H) ppm; MS (MM-ES, APCI): negative mode 257.0 [M +HCO2f.
The synthetic route of 4-Biphenylacetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; KLEINBECK-RINIKER, Florian Karl; MARTIN, Benjamin; PENN, Gerhard; VENTURONI, Francesco; SCHLAMA, Thierry; RUCH, Thomas; ALLMENDINGER, Thomas; WIETFELD, Bernhard; FILIPPONI, Paolo; (104 pag.)WO2017/98430; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts