Rooney, C. S. published the artcileInhibitors of glycolic acid oxidase. 4-Substituted 3-hydroxy-1H-pyrrole-2,5-dione derivatives, Quality Control of 30482-87-2, the main research area is hydroxypyrroledione preparation glycolate oxidase inhibition; urinary oxalate calculi hydroxypyrroledione; QSAR hydroxypyrroledione glycolate oxidase inhibition.
The title compounds I (R = aryl, aryloxy, heterocycle, etc.; R1 = H, Me, or Ph) and related ones were prepared and evaluated as orally absorbable inhibitors of glycolic acid oxidase (GAO) [9028-71-1] and to examine their effect on oxalate production in animals. Inhibitors of GAO are of interest as potentially useful drugs for treatment of Ca oxalate renal lithiasis and the primary hyperoxalurias. Rat liver perfusion with 3 of the most potent I have shown effective inhibition of the conversion of glycolate to oxalate in this organ. 4-(4′-Bromo[1,1′-biphenyl]-4-yl)-3-hydroxy-1H-pyrrole-2,5-dione (I; R = C6H4-4-(4-BrC6H4); R1 = H) [77529-42-1] administered orally to ethylene glycol treated rats showed reduction in oxalate excretion in urine. QSAR are discussed.
Journal of Medicinal Chemistry published new progress about Enzyme kinetics. 30482-87-2 belongs to class nitriles-buliding-blocks, name is 2,6-Dichloro-4-methoxybenzonitrile, and the molecular formula is C8H5Cl2NO, Quality Control of 30482-87-2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts