Category: 3032-92-6

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. COA of Formula: C9H5N.

Reddy, Mandapati Bhargava;Prasanth, Kesavan;Anandhan, Ramasamy research published 《 Controlled Photochemical Synthesis of Substituted Isoquinoline-1,3,4(2H)-triones, 3-Hydroxyisoindolin-1-ones, and Phthalimides via Amidyl Radical Cyclization Cascade》, the research content is summarized as follows. A controlled radical cyclization cascade of isoquinoline-1,3,4(2H)-triones I(R = H, 7-Cl, 7-Br,6-Cl), 3-hydroxyisoindolin-1-ones II (R¹ = Ph, 3-chloro-4-fluorophenyl, cyclopentyl, cyclohexyl, etc.; R² = Ph, Bu, 4-phenylphenyl, naphthalen-1-yl, etc.; R³ = H, 5-Cl, 6-Br), and phthalimides III from o-alkynylated benzamides R⁴-2-R²CCC₆H₃C(O)NHR¹ (R⁴ = H, 4-Cl, 5-Br) by metal-free photoredox catalyzed amidyl N-centered radical addition to the C-C triple bond using the proton-coupled electron transfer (PCET) process under mild reaction conditions was reported. A time tunable synthesis of 3-hydroxyisoindolin-1-ones II and phthalimides III via β-carbonyl-C(sp³) bond cleavage was also achieved under visible light irradiation A mechanistic rationale for the radical cyclization cascade is supported by various control and quenching experiments as well as EPR studies.

COA of Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. SDS of cas: 3032-92-6.

Ru, Guang-Xin;Zhang, Meng;Zhang, Ting-Ting;Jiang, Xiao-Lei;Gao, Guang-Qin;Zhu, Xiu-Hong;Wang, Shun;Fan, Cai-Ling;Li, Xiao;Shen, Wen-Bo research published 《 Copper catalyzed dearomatization by Michael-type addition of indolyl ynones: divergent synthesis of functionalized spiroindoles and cyclopenta[c]quinolin-3-ones》, the research content is summarized as follows. Described herein is a novel copper-catalyzed multifunctionalization of alkyne-tethered indoles, allowing the practical and efficient synthesis of a diverse array of valuable dihalogen-substituted spiroindoles containing tetrasubstituted alkenes which can be readily functionalized further to obtain various spiroindolines. The construction of synthetically challenging quaternary spirocyclic carbons and tetrasubstituted alkenes is easily achieved in a single operation. Importantly, an unexpected dearomatization of alkyne-tethered indoles via Michael-type addition is involved in this tandem sequence. Furthermore, this Cu catalysis is also applicable to the regioselective synthesis of cyclopenta[c]quinolin-3-ones from readily available indolyl ynone homologues by skeletal rearrangement.

SDS of cas: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Formula: C9H5N.

Ruengsangtongkul, Sureeporn;Kuribara, Takahito;Chaisan, Nattawadee;Tummatorn, Jumreang;Thongsornkleeb, Charnsak;Ruchirawat, Somsak research published 《 Ceric Ammonium Nitrate Promoted Oxidative Coupling of Terminal Alkynes and 1,3-Keto Esters: A Synthesis of Unsymmetrical 1,1,2-Triacylalkenes》, the research content is summarized as follows. Unsym. 1,1,2-triacylalkenes were conveniently prepared by the oxidative coupling of 1,3-keto esters with terminal alkynes by employing 4.0 equiv of inexpensive ceric ammonium nitrate (CAN) as the oxidant in acetonitrile as the solvent at 0 °C. The method is milder than previously reported methods and can be conducted under air, thereby demonstrating its practicality and versatility for preparing these useful building blocks. The reaction was believed to occur by a single-electron-transfer process of the 1,3-keto ester substrate initiated by CAN to generate an α-radical species that quickly added to the terminal alkyne partner in the reaction. Subsequent oxidation of the resulting vinyl radical by air and CAN then lead to the formation of the triacylalkene product as a mixture of E- and Z-isomers. The reaction was shown to be general, with 27 illustrative examples of the formation of the desired products in up to quant. yield and with moderate to excellent alkene geometrical selectivities.

Formula: C9H5N, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Electric Literature of 3032-92-6.

Scapin, Elisandra;Zimmer, Georgia C.;Vieira, Jean C. B.;Rodrigues, Catarina A. B.;Afonso, Carlos A. M.;Zanatta, Nilo;Bonacorso, Helio G.;Frizzo, Clarissa P.;Martins, Marcos A. P. research published 《 Reactivity of trifluoromethyl-tetrazolo[1,5-a]pyrimidines in click chemistry and hydrogenation》, the research content is summarized as follows. The synthetic potential of tetrazolo[1,5-a]pyrimidines to obtain new pyrimidine derivatives via click chem. and hydrogenation was reported. Click chem. reactions of trifluoromethyl-tetrazolo[1,5-a]pyrimidines with terminal acetylenes produced unprecedented trifluoromethylated triazolylpyrimidines at excellent yields (84-98%), and one of them was active against all tested microorganisms, with moderate min. inhibitory concentration values (62.5-15.62μg/mL). Hydrogenation was performed using Pd/C-H₂ in MeOH under conventional, photochem., and pressure (5 bar) conditions. Hydrogenation was an excellent method for obtaining 2-amino-6-aryl-4-trifluoromethylpyrimidines and/or 2-amino-6-aryl-4-trifluoromethyltetrahydropyrimidines with a preference for 2-aminopyrimidine formation. Photochem. hydrogenation was the only pathway for reducing aryl-brominated substrates without dehalogenation. The reduction of trifluoromethyl-substituted tetrazolo[1,5-a]pyrimidines furnished 2-amino-6-aryl-4-trifluoromethylpyrimidines instead of the corresponding tetrahydropyrimidines. However, the hydrogenation of non-trifluoromethylated tetrazolo[1,5-a]pyrimidines showed a preference for tetrahydropyrimidine formation.

Electric Literature of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Safety of 4-Ethynylbenzonitrile.

Sebris, Armands;Novosjolova, Irina;Traskovskis, Kaspars;Kokars, Valdis;Tetervenoka, Natalija;Vembris, Aivars;Turks, Maris research published 《 Photophysical and Electrical Properties of Highly Luminescent 2/6-Triazolyl-Substituted Push-Pull Purines》, the research content is summarized as follows. New push-pull N(9)-alkylated 6-piperidino-2-triazolylpurine and 2-piperidino-6-triazolylpurine derivatives are synthesized, and their optical and optoelectronic properties are comprehensively characterized with exptl. and computational methods. The compounds possess intense violet or blue fluorescence with fluorescence quantum yields of up to 91% in solution and 40% in host-free films. Depending on their structural composition, the compounds have ionization energy in the range of 5.25-6.04 eV, electron affinity of 2.18-3.15 eV, and triplet energy of 2.52-2.95 eV. Due to the presence of hole-transporting purine and electron-transporting triazole fragments, compounds exhibit bipolar charge-transportation ability. Despite the favorable emissive properties of the studied push-pull purines, their electroluminescence in thin films is quenched owing to large current densities that are present even at a moderate driving voltage. This marks application directions related to a predominantly charge-transportation functionality as the most suitable for this compound class.

Safety of 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Name: 4-Ethynylbenzonitrile.

Pradhan, Tapas R.;Paudel, Mukti;Feoktistova, Taisiia;Cheong, Paul Ha-Yeon;Park, Jin Kyoon research published 《 Silaborative Assembly of Allenamides and Alkynes: Highly Regio- and Stereocontrolled Access to Bi- or Trimetallic Skipped Dienes》, the research content is summarized as follows. A highly stereo- and regiocontrolled multicomponent approach to skipped 1,4-dienes decorated with one boryl and two silyl functionalities, XNR¹CH:C(Bpin)CH₂CR²:CHSiMe₂Ph (X = sulfonyl, acyl; R¹ = benzyl, alkyl; R² = silyl, aryl, alkyl, carboxy) is described, comprising three-component reaction of allenamides XNR¹CH:C:CH₂ with alkynes R²CCH and silylborane Me₂PhSiBpin, catalyzed by Pd₂(dba)₃. This Pd-catalyzed atom-economical union of allenamides, alkynes, and Me₂PhSiBpin (or Et₃SiBpin) proceeds without the use of phosphine ligands, instead relying on chelation through the internal amide group of the allenamide sulfonyl. A variety of alkynes, including those derived from complex bioactive mols., can be efficiently coupled with allenamides and Me₂PhSiBpin in good yields and with excellent selectivity. The synthetic potential was demonstrated through multiple valuable chemoselective transformations, establishing new disconnections for functionalized dienes. D. functional theory calculations revealed that the reaction first proceeded through borylation of the allenamide, followed by silylation of the alkyne and then reductive elimination, which convergently assemble the skipped 1,4-diene.

Name: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Synthetic Route of 3032-92-6.

Pramod Charpe, Vaibhav;Gupta, Mahima;Chu Hwang, Kuo research published 《 Visible-Light-Induced Oxidative α-keto-Dichlorination of Arylalkynes by CuCl₂ at Room Temperature》, the research content is summarized as follows. A visible light-induced oxidative α-keto-dichlorination of terminal and internal aryl alkynes was developed to form dichloroacetophenones (DCAPs) and dichlorophenyl-acetophenones (DCPAPs), resp., by using CuCl₂ as a photoredox catalyst in the presence of air at room temperature (without using any exogenous photocatalyst). Here, photoexcited CuCl₂ underwent ligand-to-metal charge transfer to generate a Cl radical, which readily added to the alkynes to form DCAPs or DCPAPs in the presence of O₂. This α-keto-dichlorination reaction is a green and mild protocol as it produced water as the only byproduct. Moreover, the evaluation of green chem. metrics indicated that the E-factor (mass of wastes/mass of products) of the current α-keto-chlorination method is around 10.1 times lower than that of a literature-reported photochem. method. The Eco Scale value (score 55, which on a scale of 0-100 indicates an acceptable synthesis) signifies that this process is simple, highly efficient, eco-friendly, and cost-effective.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Synthetic Route of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-Ethynylbenzonitrile.

Qin, Yinhui;Sun, Min;Zhang, Na;Yang, Yan;Ma, Peizhi research published 《 Synthesis and biological evaluation of antibacterial activity of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4′′- and 11-OH positions》, the research content is summarized as follows. Bacterial infection is still one of the diseases that threaten human health, and bacterial drug resistance is widespread worldwide. As a result, their eradication now largely relies on antibacterial drug discovery. Here, we reveal a novel approach to the development of 14-membered macrolide antibiotics by describing the design, synthesis, and evaluation of novel clarithromycin derivatives incorporating 1,2,3-triazole moieties at the 4′′- and 11-OH positions. Using chem. synthesis, I [R¹ = H, 4-Me, 4-Et, etc.,], II [R² = 4-Et, 4-Pr, 4-tert-Bu, etc.,] were prepared, and their antibacterial properties were profiled. We found that compounds I = [R¹ = 4-Bu, 4-n-pentyl, 4-n-hexyl and 4-Ph, 4-n-pentoxy, 4-F, 4-Cl, 4-Br, 3,5-bis(trifluoromethyl)] and II = [R² = 4-n-pentyl] were as potent as azithromycin against Enterococcus faecalis ATCC29212. Furthermore, compounds I = [R¹ = 4-Et, 4-Pr, 4-Cl and 4-Br] showed slightly improved antibacterial activity (2-fold) against Acinetobacter baumannii ATCC19606 when compared with azithromycin and clarithromycin. In addition, compounds I = [R¹ = 4-Bu, 4-n-pentyl, 4-Ph, 4-n-pentoxy and 3,5-bis(trifluoromethyl)] exhibited excellent antibacterial activity against Staphylococcus aureus ATCC43300, Staphylococcus aureus PR, and Streptococcus pneumoniae ER-2. These compounds were generally 64- to 128-fold more active than azithromycin, and 32- to 128-fold more active than clarithromycin. The results of mol. docking indicated that compound 8f may bind to the nucleotide residue A752 through hydrogen-bonding, hydrophobic, electrostatic, or π-π stacking interactions. The predicted ClogP data suggested that higher values of ClogP (>6.65) enhanced the antibacterial activity of compounds such as I = [R¹ = 4-Bu, 4-n-pentyl, 4-Ph, 4-n-pentoxy and 3,5-bis(trifluoromethyl)]. The determination of the min. bactericidal concentration showed that most of the tested compounds were bacteriostatic agents. From this study of bactericidal kinetics, we can conclude that compound 8f had a concentration- and time-dependent effect on the proliferation of Staphylococcus aureus ATCC43300. Finally, the results of the cytotoxicity assay showed that compound I = [R¹ = 4-n-pentyl] exhibited no toxicity at the effective antibacterial concentration

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-Ethynylbenzonitrile.

Qing, Bin;Bai, Xueying;Huang, Liliang;Zhao, Jiahui;Zhou, Pengyu;Feng, Huangdi research published 《 Vinyl fluorosulfonamide: a practical vinyl electrophilic reagent for mild and efficient synthesis of ketones under catalyst- and additive-free conditions》, the research content is summarized as follows. A catalyst- and additive-free hydrolysis of alkenyl fluorosulfonamides is achieved, providing an efficient approach for the synthesis of various aryl ketones in moderate to excellent yields. This reaction exhibits broad functional group compatibility without the formation of undesired desulfonation compounds Moreover, the procedure operates under the mild conditions avoiding the use of addnl. metal catalysts or potential security risk substrate (vinyl azide), and the reaction finishes in short reaction time (30 min) at room temperate.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Recommanded Product: 4-Ethynylbenzonitrile.

Qu, Hongmin;Chen, Yu;Ceng, Xiangling;Tang, Pei;Wang, Huijing;Chen, Fener research published 《 Enantioselective synthesis of chiral 3-alkynyl-3-hydroxyindolin-2-ones by Zn/bis(sulfonamide)-diamine catalyzed asymmetric addition of alkynes to isatins》, the research content is summarized as follows. The catalytic enantioselective alkynylation of isatins, catalyzed by a Zn(OCOCF₃)₂/chiral bis(sulfonamide)-diamine (BSDA) catalyst under mild condition, had been developed. The desired chiral 3-alkynyl-3-hydroxy-2-oxindoles I [R = H, 5-F, 7-Me, etc.; R¹ = Et, Bn, MOM, PMB; R² = cyclopropyl, Ph, 2-thienyl, etc.] were obtained in moderate to excellent yields (up to 96%) and good to excellent enantioselectivities (up to 97% ee). The reaction was broad in scope with respect to aryl-substituted terminal alkynes and substituted isatins.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts