Category: 3032-92-6

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. HPLC of Formula: 3032-92-6.

Strauss, Marie E.;Santaloci, Taylor J.;Fortenberry, Ryan C. research published 《 Valence-, Dipole- and Quadropole-Bound Electronically Excited States of Closed-Shell Anions Formed by Deprotonation of Cyano- and Ethynyl-Disubstituted Polycyclic Aromatic Hydrocarbons》, the research content is summarized as follows. Dicyano-functionalized benzene and naphthalene anion derivatives exhibit a relatively rich population of electronically excited states in stark contrast to many assumptions regarding the photophysics of anions in general. The present work has quantum chem. analyzed the potential electronically excited states of closed-shell anions created by replacing hydrogen atoms with valence-bound lone pairs in benzene and naphthalene difunctionalized with combinations of -CN and -C₂H. Dicyanobenzene anion derivatives can exhibit dipole-bound excited states as long as the cyano groups are not in para position to one another. This also extends to cyanoethynylbenzene anions as well as deprotonated dicyano- and cyanoethynylnaphthalene anion derivatives Diethynyl functionalization is less consistent. While large dipole moments are created in some cases for deprotonation on the -C₂H group itself, the presence of electronically excited states beyond those that are dipole-bound is less consistent. Beyond these general trends, 2-dicyanonaphthalene-34 gives strong indication for exhibiting a quadrupole-bound excited state, and the 1-cyanoethynylnaphthalene-29 and -36 anion derivatives are shown to possess as many as two valence-bound excited states and one dipole-bound excited state. These photophys. properties may have an influence on regions where polycyclic aromatic hydrocarbons are known to exist such as in various astrochem. environments or even in combustion flames.

HPLC of Formula: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H5N.

Su, Lebin;Xie, Shimin;Dong, Jianyu;Pan, Neng;Yin, Shuang-Feng;Zhou, Yongbo research published 《 Copper-Catalyzed 6-endo-dig Cyclization-Coupling of 2-Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water》, the research content is summarized as follows. The cyclization-coupling reaction of 2-bromoaryl ketones 2-Br-4-R-5-R¹C₆H₂C(O)Me (R = H, Cl, F, MeO; R¹ = H, Cl, Me), 1-(pyridin-3-yl)ethan-1-one and terminal alkynes R²CCH (R² = Ph, 4-bromophenyl, pyridin-3-yl, etc.) is first realized by copper catalysis, which produces polyfunctional naphthyl aryl ethers I (X = CH, N) in moderate to excellent yields with broad substrate scope and good functional group tolerance. This reaction proceeds via 6-endo-dig cyclization and C(sp²)-O coupling using green H₂O as the unique solvent and 5-bromopyrimidin-2-amine as the critical additive. Mechanistically, a unique Cu(III)-acetylide probably is the key intermediate, which allows exclusive 6-endo-dig selectivity.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Name: 4-Ethynylbenzonitrile.

Sun, Yaru;Tang, Xiaochan;Li, Xiaobing;Kong, Xiuqi;Tian, Minggang;Wang, Yue;Dong, Baoli research published 《 PET-ESIPT-based fluorescent probes for revealing the fluctuation of peroxynitrite (ONOO^–) in living cells, zebrafishes and brain tissues》, the research content is summarized as follows. Peroxynitrite (ONOO^–) plays crucial roles in a variety of physiol. and pathol. processes in living systems, and therefore, real-time and in situ imaging of ONOO^– is of great significance to in-depth study its biol. roles. Herein, we have developed PET-ESIPT-based fluorescent probes (BCN and BCN-A) for the detection of ONOO^– in living cells, zebrafishes and brain tissues. BCN was a highly sensitive ONOO^– probe in which the fluorescence property of the fluorophore was simultaneously controlled by PET and ESIPT mechanisms, and transformed to BCN-A via acetylation. Especially, BCN showed large Stokes shift in response to ONOO^–, and displayed high selectivity to ONOO^–. BCN-A employed the acetate group to switch off ESIPT process of the fluorophore and improve the membrane permeability. In living cells, BCN-A released an ONOO^–-responsive probe (BCN) by the hydrolysis of esterase, and then detected ONOO^–. Biol. imaging demonstrated that although both metformin and rotenone are mitochondrial complex I inhibitors, metformin can increase the generation of ONOO^– while rotenone had no significant influence on the generation of ONOO^– in living cells and zebrafishes. Moreover, the amygdala and perirhinal/entorhinal cortex in the brain of depressive mouse both showed increasing fluorescence intensity relative to those of normal mouse, which suggested that the LPS-induced depressive disorder could result in the generation of ONOO^– in the two brain areas of mouse. We expect that the probes (BCN and BCN-A) could extensively serve as the powerful mol. tools to investigate the biol. roles of ONOO^– for the in-depth study of drug mechanism and depressive disorder.

Name: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Safety of 4-Ethynylbenzonitrile.

Tang, Jun-Bin;Bian, Jun-Qian;Zhang, Yu-Shuai;Cheng, Yong-Feng;Wen, Han-Tao;Yu, Zhang-Long;Li, Zhong-Liang;Gu, Qiang-Shuai;Chen, Guo-Qiang;Liu, Xin-Yuan research published 《 Copper-Catalyzed anti-Selective Radical 1,2-Alkylarylation of Terminal Alkynes》, the research content is summarized as follows. A copper-catalyzed highly anti-selective radical 1,2-alkylarylation of terminal alkynes with aryl boronic acids and alkyl bromides has been established. The reaction exhibits high compatibility with a wide range of terminal alkynes and diverse aryl boronic acids, thus providing facile access to various stereodefined trisubstituted alkenes in high yield under mild reaction conditions. Preliminary mechanistic investigations support the formation of alkyl radicals and their subsequent addition to alkynes in the reaction.

Safety of 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: 4-Ethynylbenzonitrile.

Tatevosyan, Stepan S.;Kotovshchikov, Yury N.;Latyshev, Gennadij V.;Lukashev, Nikolay V.;Beletskaya, Irina P. research published 《 Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling》, the research content is summarized as follows. A convenient approach to assemble 1,2,3-triazole-fused 4 H-3,1-benzoxazines I (R = H, 6-Me, 7-I, 7,8-dimethoxy, etc.; R¹ = H, Me, Ph; R² = Bu, cyclopropyl, Ph, etc.) has been developed. Diverse alc.-tethered 5-iodotriazoles II (R³ = H, 6-Me, 5-I, 4,5-dimethoxy, etc.), readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles I. The intramol. C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products I in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na₂CO₃ in acetonitrile at 100°C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Related Products of 3032-92-6.

Treat, Anny;Henri, Vianie;Liu, Junke;Shen, Joyce;Gil-Silva, Mauricio;Morales, Alejandro;Rade, Avaneesh;Tidgewell, Kevin Joseph;Kolber, Benedict;Shen, Young research published 《 Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice》, the research content is summarized as follows. Capsaicin, the compound in hot chili peppers responsible for their pungency and an agonist of the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), has long been known to promote the desensitization of nociceptors at high concentrations This has led to the utilization and implementation of topical capsaicin cream as an analgesic to treat acute and chronic pain. Critically, the application of capsaicin cream is limited due to capsaicin′s high pungency, which is experienced prior to analgesia. To combat this issue, novel capsaicin analogs were developed to provide analgesia with reduced pungency. Analogs reported in this paper add to and show some differences from previous structure-activity relationship (SAR) studies of capsaicin-like mols. against TRPV1, including the necessity of phenol in the aromatic “A-region”, the secondary amide in the “B-region”, and modifications in the hydrophobic “C-region”. This provided a new framework for de novo small-mol. design using capsaicin as the starting point. In this study, we describe the synthesis of capsaicin analogs, their in vitro activity in Ca²⁺ assays, and initial in vivo pungency and feasibility studies of capsaicin analogs YB-11 and YB-16 as analgesics. Our results demonstrate that male and female mice treated with YB capsaicin analogs showed diminished pain-associated behavior in the spontaneous formalin assay as well as reduced thermal sensitivity in the hotplate assay.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Related Products of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Computed Properties of 3032-92-6.

Shao, Chukai;He, Ying;Yin, Hongquan;Chen, Fu-Xue research published 《 Me₃SiCl-Catalyzed Electrophilic Thiocyanation/Cyclization of Alkynylbenzoates to Synthesize 4-Thiocyanatoisocourmarins》, the research content is summarized as follows. A metal-free and regioselective electrophilic thiocyanation/cyclization of alkynylbenzoates was developed to afford series of thiocyanato-containing isocourmarins catalyzed by Me₃SiCl. Tandem thiocyanation/6-endo cyclization of alkynylbenzoates was achieved using N-thiocyanatosuccinimide (NTS). A wide scope of substrates and functional groups was tolerated with moderate to excellent yield up to 98%. The mild reaction conditions made this protocol more practical to access isocourmarins bearing a thiocyanato group with diversed transformations.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Computed Properties of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H5N.

Sharma, Deepak;Hussain, Yaseen;Sharma, Manisha;Chauhan, Pankaj research published 《 Electrochemical cascade synthesis of α-thio-substituted masked aldehydes》, the research content is summarized as follows. The recent upsurge in electrosynthesis has provided efficient and sustainable synthetic strategies for procuring valuable mols. and their precursors. In this context, authors have achieved an efficient cascade synthesis of β,β-dialkoxy sulfides under ambient electrochem. conditions. The electrolysis of terminal aryl alkynes, aromatic and aliphatic thiols, and alcs. initiates a cascade sequence involving the thiol-yne reaction/1,2-thio migration via nucleophilic attack of alkoxides to provide α-thio-substituted masked aldehydes in good yields for a diverse range of substrates. The cascade sequence also works well when using acetic acid and acetic anhydride instead of alcs.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Electric Literature of 3032-92-6.

Shen, Liu-Yu;Sun, Yu;Wang, Yu-Qi;Li, Bing;Yang, Wen-Chao;Dai, Peng research published 《 K₂S₂O₈-promoted radical trifluoromethylthiolation/spirocyclization for the synthesis of SCF₃-featured spiro[5,5]trienones》, the research content is summarized as follows. A direct and efficient strategy for the trifluoromethylthiolation and dearomatization of biaryl ynones with stable and readily available AgSCF₃ has been developed. The reaction occurs smoothly in the presence of K₂S₂O₈ via a 6-exo-trig radical cyclization, providing a variety of SCF₃-containing spiro [5,5]trienones in good yields.

Electric Literature of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. SDS of cas: 3032-92-6.

Shi, Jie;Xu, Qiao-Lin;Ni, Yu-Qing;Li, Lin;Pan, Fei research published 《 Radical Multicomponent Alkyl Alkynylation of Propellane via Synergistic Photoredox and Copper Catalysis》, the research content is summarized as follows. A novel and efficient reaction to synthesize alkyl-alkynyl-substituted BCP derivatives I (R = oxan-4-yl, cyclohexyl, propan-2-yl, etc.; R¹ = Ph, thiophen-2-yl, 4-chlorophenyl, etc.) by synergistic photoredox and copper catalysis at room temperature was decribed. The mild reaction conditions, simple protocol, broad functional group tolerance, and high efficiency of this procedure make it a valuable strategy for accessing alkynyl-substituted BCPs I.

SDS of cas: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts