Category: 3032-92-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3032-92-6, name is 4-Ethynylbenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C9H5N

General procedure: An8 ml glass vial was charged with the alkyne (0.3 mmol), aryl iodide(0.25 mmol), K2CO3 (79 mg, 0.5 mmol), CuI (2.4 mg, 5 mol%), 3-Pphen(3.9 mg, 5 mol%), PEG-400 (20 mg, 20 mol%) and water (1 ml) under argon. The vial was closed with a Teflon cap and the heterogeneous reaction mixture was stirred at 100 C for 3 or 6 h (see Scheme 1). After cooling, the mixture was extracted with EtOAc, the extract was dried overMgSO4. After evaporation, the residue was purified by flash chromatography on silica gel with light petroleum as the eluent. 1H and 13C NMR spectroscopic data of products were consistent with those describedpreviously.13

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Mitrofanov, Alexander Yu.; Beletskaya, Irina P.; Mendeleev Communications; vol. 29; 4; (2019); p. 378 – 379;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3032-92-6, name is 4-Ethynylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 4-Ethynylbenzonitrile

General procedure: To a low pressure reactor equipped with magnetic stirreralkyne (0.15 mmol), Cs2CO3(0.30 mmol), copper catalyst(0.0075 mmol), n-BuBr (0.18 mmol) and DMF (2 mL)were added. CO2(2 atm.) was introduced into the reactionmixture by triply purging the reactor with CO2.Thereaction mixture was stirred at 60 C for 6 h or 16 h. Afterthe reaction, the mixture was cooled to room temperatureand diluted with DMF. After centrifugation, the organicphase was concentrated under reduced pressure and purifiedby column chromatography on silica gel (eluent petroleumether/EtOAc 20:1). Isolated product was dried undervacuum.

According to the analysis of related databases, 3032-92-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bondarenko, Grigoriy N.; Dvurechenskaya, Ekaterina G.; Magommedov, Eldar Sh.; Beletskaya, Irina P.; Catalysis Letters; vol. 147; 10; (2017); p. 2570 – 2580;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts