Category: 2973-50-4

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2973-50-4 as follows. category: nitriles-buliding-blocks

(2) (2-Aminophenyl)acetonitrile (1.34 g) was dissolved in THF (10 mL), and concentrated hydrochloric acid was added, followed by heating under reflux for 2 hours. The solvent was evaporated, and ethanol (5 mL) and diisopropyl ether (15 mL) were added to suspend the concentrated residue. The crystals were recovered by filtration to obtain 2-imino-2,3-dihydro-1H-indole monohydrochloride (1.42 g).1H NMR (DMSO) delta: 12.46 (s,1H) 10.25 (s,1H), 10.00 (s,1H), 7.42-7.11 (m,4H), 4.18 (s,2H)

According to the analysis of related databases, 2973-50-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1367058; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 2973-50-4, These common heterocyclic compound, 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In an Erlenmeyer flask, 2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazide (4) (1.0 mmol), aromatic nitriles (1.0 mmol) and DMAP (30 mol%) were taken in ethanol (15 mL). The reaction mixture was irradiated inside a synthetic microwave oven (Make-Ethosi Milestone with temperature control) for about 20-25 min (700 W). After completion of reaction (monitored by TLC), the mixture was concentrated to obtain the solid product. The solid product formed was filtered, dried and recrystallized from ethanol.

Statistics shows that 2-(2-Aminophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 2973-50-4.

Reference:
Article; Sangshetti, Jaiprakash N.; Kalam Khan, Firoz A.; Chouthe, Rashmi S.; Damale, Manoj G.; Shinde, Devanand B.; Chinese Chemical Letters; vol. 25; 7; (2014); p. 1033 – 1038;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H8N2

To (2-aminophenyl)acetonitrile (10 g, 75.7 mmol) in DMF (100 ml) was added benzyl bromide (12.9 g, 75.7 mmol) and potassium carbonate (16.6 g, 1 13.5 mmol) at RT. The reaction was stirred at RT overnight. Reaction was filtered and the solvent was removed. The resulting mixture was extracted with EtOAc and washed with water and sat. sodium chloride (aq). The organic layer was dried, then solvent was removed. The mixture was chromatographed on silica gel (Hexand:EtOAc) and gave the titled compound (9.94g, 59%).

The synthetic route of 2973-50-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; GRAHAM, Keith; BUCHGRABER, Philipp; AIGUABELLA FONT, Nuria; HEINRICH, Tobias; BRAeUER, Nico; KUHNKE, Lara, Patricia; WITTROCK, Sven; LANGE, Martin; BADER, Benjamin; PRECHTL, Stefan; LIENAU, Philip; KOPITZ, Charlotte, Christine; NOWAK-REPPEL, Katrin; POTZE, Lisette; STEUBER, Holger; HARVEY, Rebecca, Ann; KIRK, Ralph, Steven; (699 pag.)WO2020/48829; (2020); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 2973-50-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of 6-(difluoromethyl) pyridazine-4-carboxylic acid Int-29 (1 g, 5.75 mmol) in ethylacetate (60 mE) was added 2-(2-aminophenyl)acetoni- trile (759 mg, 5.75 mmol) andtriethylamine (1.6 mE, 11.49 mmol) at room temperature under an inert atmosphere. To this was added propylphosphonic anhydride (50% in EtOAc, 9.14 mE, 14.37 mmol) drop wise at 00 C. The reaction mixture was gradually warmed to room temperature and stirred for 2 h. After consumption of starting material (by TEC), the reaction mixture was basified using saturated sodium bicarbonate solution to pH .-8 and extracted with EtOAc (2×50 mE). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude material was triturated with n-pentane (2×25 mE) and dried under vacuum to afford N-(2-(cyanomethyl)phenyl)-6-(difluoromethyl)pyridazine- 4-carboxamide (1.4 g, 4.86 mmol, 85%) as a yellow solid.11619] ?H NMR (500 MHz, DMSO-d5): oe 10.77 (s, 1H),9.80 (s, 1H), 8.45 (s, 1H), 7.54-7.49 (m, 1H), 7.45-7.30 (m, 4H), 4.02 (s, 2H)11620] EC-MS: mlz 288.9 [M+H] at 2.25 RT (98.33% purity)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Aminophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; Hoekstra, William J.; (156 pag.)US2018/185362; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2973-50-4

Example 32A Under inert atmosphere a solution of 500 mg (3.78 mmol) of 2-Aminophenylacetonitrile and 1 mL (7.57 mmol) of 2,5-Dimethoxytetrahydrofuran in 5 mL of Acetic acid was heated to 60 C. for 2 hours. After cooling the reaction mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on SiO2 using cyclohexane/ethyl acetate mixture of increasing polarity (from 100% cyclohexane to 100% ethyl acetate) as eluant. 470 mg of the title compound (68%) were obtained.GC-MS (Method 3A.1): Rt: 9.75 minMS: 182 [M]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2973-50-4.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/115863; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2973-50-4, category: nitriles-buliding-blocks

Adding the reactor 100mmol O-aminophenyl acetonitrile, 105mmol NBS and 100g polyethylene glycol 400, the reaction under stirring at room temperature for 2 hours. After the reaction, the mixture into ethyl acetate, saturated salt water for washing, the aqueous layer after extraction with ethyl acetate, combined with the organic layer (the washing of the organic layer and extraction of the organic layer), using anhydrous Na2SO4drying, negative-pressure evaporation to remove the solvent, the residue is column chromatography (petroleum ether/ethyl acetate, two volume ratio of 2:1) purification, to obtain the product 2-amino-5-brombenethane

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Aminophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wenzhou University; Chen, Jiuxi; Yu, Shuling; Cheng, Tianxing; Hu, Kun; Qi, Linjun; Liu, Miaochang; Wu, Huayue; (13 pag.)CN105884673; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2973-50-4 as follows. Computed Properties of C8H8N2

(2) (2-Aminophenyl)acetonitrile (1.34 g) was dissolved in THF (10 mL), and concentrated hydrochloric acid was added, followed by heating under reflux for 2 hours. The solvent was evaporated, and ethanol (5 mL) and diisopropyl ether (15 mL) were added to suspend the concentrated residue. The crystals were recovered by filtration to obtain 2-imino-2,3-dihydro-1H-indole monohydrochloride (1.42 g).1H NMR (DMSO) delta: 12.46 (s,1H) 10.25 (s,1H), 10.00 (s,1H), 7.42-7.11 (m,4H), 4.18 (s,2H)

According to the analysis of related databases, 2973-50-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1367058; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 2973-50-4

EXAMPLE 4 2,2,3,3,4,4,4-Heptafluoro-N-[2-(1H-tetrazol-5-ylmethyl)phenyl]butanamide A mixture of 2-aminobenzylcyanide (15 g) [Rousseau et al., JACS 72, 3047 (1950)], diisopropylethylamine (16 g) and dichloromethane (400 mL) was cooled in an ice bath under a nitrogen atmosphere. Heptafluorobutyryl chloride (28.9 g) in dichloromethane (100 mL) was added dropwise and the reaction was left to warm gradually to room temperature overnight. A 10% aqueous HCl solution was added and the organic phase was separated and dried over MgSO4. After filtration and concentration with a rotary evaporator, the crude, orange oil (42 g) was purified by high pressure liquid chromatography to give 35.4 g of 2,2,3,3,4,4,4-heptafluoro-N-[2-(cyanomethyl)phenyl]butanamide as a white solid, m.p. 76-79 C.

According to the analysis of related databases, 2973-50-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Home Products Corporation; US4764623; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 2973-50-4,Some common heterocyclic compound, 2973-50-4, name is 2-(2-Aminophenyl)acetonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2-Aminophenyl)acetonitrile (9) (2.64 g, 20.0 mmol) was dissolved in 50 mL of acetic acid. KI (3.65 g, 22.0 mmol) was added followed by dropwise addition of 30% H2O2 (2.24 mL, 22.0 mmol). The reaction mixture was then stirred under nitrogen for 90 min, poured into 200 mL of 0.1 M sodium thiosulfate solution, and extracted with ethyl acetate (3 ¡Á 200 mL). The organic fractions were combined, washed with 0.1 M sodium thiosulfate (2 ¡Á 200 mL), satd sodium bicarbonate (2 ¡Á 200 mL) and brine (2 ¡Á 200 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Purification by automated flash chromatography (400 g silica gel, 25% ethyl acetate/hexanes) afforded 10 (3.5 g, 68%). 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.41 (s, 2H), 6.53 (d, J = 8.34 Hz, 1H), 7.30 (dd, J = 8.59, 2.02 Hz, 1H), 7.39 (d, J = 2.02 Hz, 1H), NH2 protons not resolved.

The synthetic route of 2973-50-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bobko, Mark A.; Evans, Karen A.; Kaura, Arun C.; Shuster, Leanna E.; Su, Dai-Shi; Tetrahedron Letters; vol. 53; 2; (2012); p. 200 – 202;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

2973-50-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2973-50-4 name is 2-(2-Aminophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suitable amount of an organic solvent (a mixture of 1-cyanopropyl-3-methylimidazolium tetrafluoroborate and ethylene glycol at a mass ratio of 1: 4)The compound of formula (I) above 100mmo 1 is added,100mmo 1 The compound of formula (II)15 mmo 1 catalyst (3.75 mmol1-diphenylphosphino-1 ‘_ (di-tert-butylphosphino) ferrocene11.25 mmol Tin iodide mixture),150 mmol of base 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) with16 mmol Promoter Cerium triflate (Ce(OTf) 3), then warmed to 80 C, and the reaction was stirred at this temperature for 12 hours;[0036] After completion of the reaction, deionized water was added to the reaction system and thoroughly shaken, washed, and then extracted with chloroform 2-3 times,The combined organic phases were washed again with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was passed over 300-400 meshSilica gel column chromatography eluting with a mixture of acetone and petroleum ether in a volume ratio of 1: 2 to give a compound of the above formula (III)The yield of the compound was 95.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Aminophenyl)acetonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Gong Xiaoqian; Bu Gonggaofamingren; (9 pag.)CN105949109; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts