These common heterocyclic compound, 28442-78-6, name is 2-Chloroisophthalonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Chloroisophthalonitrile
EXAMPLE 55A 3-Amino-2-carbomethoxy-7-cyano-benzthiophene 2-chloro-1,3-dicyanobenzene (972 mg, 6.0 mmol) was treated with 1 eq of methyl thioglycolate and 1 eq sodium carbonate in methanol as described in Example 41A to give the title compound in 65% yield. 1H NMR (300 MHz, D6-DMSO d 3.83 (s, 3H), 7.38 (bs, 2H), 7.62 (t, J=8 Hz, 1H), 8.10 (d, J=8 Hz, 1H), 8.50 (d, J=8 Hz, 1H). MS (DCI/NH3) m/e 250 (M+NH4)+.
The synthetic route of 2-Chloroisophthalonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Abbott Laboratories; US5597823; (1997); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts